Protein detail
ABCA1
Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
Protein symbol ABCA1 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 15 | Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
Protein Class
Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
22..42; Helical; 640..660; Helical; 683..703; Helical; 716..736; Helical; 745..765; Helical; 777..797; Helical; 827..847; Helical; 1041..1057; Helical; 1351..1371; Helical; 1657..1677; Helical; 1703..1723; Helical; 1735..1755; Helical; 1768..1788; Helical; 1802..1822; Helical; 1852..1872; Helical
Transmembrane Count
15
Ensembl
Entrez Gene Symbol
Gene Synonym
ABC1HDLDT1TGD
Gene Description
ATP binding cassette subfamily A member 1
Chromosome
9
Position
104781006-104928155
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBergmann gliaSingle-Nuclei Brain Specificendothelial cellSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005768 endosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0030139 endocytic vesicle
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045121 membrane raft
- GO:0045335 phagocytic vesicle
- GO:0048471 perinuclear region of cytoplasm
- GO:0097708 intracellular vesicle
Molecular Function
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0005548 phospholipid transporter activity
- GO:0008035 high-density lipoprotein particle binding
- GO:0008320 protein transmembrane transporter activity
- GO:0015485 cholesterol binding
- GO:0016887 ATP hydrolysis activity
- GO:0019905 syntaxin binding
- GO:0031210 phosphatidylcholine binding
- GO:0031267 small GTPase binding
- GO:0034185 apolipoprotein binding
- GO:0034186 apolipoprotein A-I binding
- GO:0034188 apolipoprotein A-I receptor activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0046623 sphingolipid floppase activity
- GO:0051117 ATPase binding
- GO:0090554 phosphatidylcholine floppase activity
- GO:0090556 phosphatidylserine floppase activity
- GO:0120020 cholesterol transfer activity
- GO:0140328 floppase activity
- GO:0140359 ABC-type transporter activity
Biological Process
KEGG
Reactome
- R-hsa-5619084 abc transporter disorders
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-8963896 hdl assembly
- R-hsa-556833 metabolism of lipids
- R-hsa-9024446 nr1h2 and nr1h3 mediated signaling
- R-hsa-9029569 nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux
- R-hsa-8963898 plasma lipoprotein assembly
- R-hsa-174824 plasma lipoprotein assembly remodeling and clearance
- R-hsa-400206 regulation of lipid metabolism by pparalpha
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
18 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ABCA1 | PRKY | O43930 | S | 2,054 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ABCA1 | PRKACB | P22694 | S | 2,054 | phosphorylation | Reactome_ProtMapperProtMapper | |
| ABCA1 | PRKACB | P22694 | S | 1,042 | phosphorylation | Reactome_ProtMapperProtMapper | |
| ABCA1 | PRKACG | P22612 | S | 2,054 | phosphorylation | Reactome_ProtMapperProtMapper | |
| ABCA1 | PRKACG | P22612 | S | 1,042 | phosphorylation | Reactome_ProtMapperProtMapper | |
| ABCA1 | PRKCB | P05771 | S | 1,042 | phosphorylation | KEA | KEA:17570479 |
| ABCA1 | PRKG1 | Q13976 | S | 2,054 | phosphorylation | KEA | KEA:17570479 |
| ABCA1 | RPS6KA3 | P51812 | S | 1,042 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| abc | transporter | DGIdb | No | Yes | No | No | No |
| transporter | transporter | DGIdb | No | Yes | No | No | No |
| abca | transporter | Surfaceome | No | Yes | No | No | No |
| active | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | No |
Regulatory Interaction Network
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABCA1 | O95477 | MEG10 | Q96KG7 | Yes | Yes | No | SIGNOR | SIGNOR:17205124 |
| MEG10 | Q96KG7 | ABCA1 | O95477 | Yes | Yes | No | CellTalkDBSIGNOR | CellTalkDB:17205124SIGNOR:17205124 |
| EGFR | P00533 | ABCA1 | O95477 | Yes | No | Yes | PhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:12196520ProtMapper:12196520 |
| LNX1 | Q8TBB1 | ABCA1 | O95477 | Yes | No | Yes | SIGNOR | SIGNOR:22889411 |
| ABCA1 | O95477 | APOA1 | P02647 | Yes | Yes | No | CellPhoneDBSIGNORHPRDHINTIntActInnateDB | HPRD:12084722InnateDB:22271762IntAct:12084722SIGNOR:15347662HINT:12084722HINT:22271762IntAct:30458687 |
| APOA1 | P02647 | ABCA1 | O95477 | Yes | Yes | No | CellChatDBCellTalkDBCellPhoneDBSIGNORHPRDHINTIntActInnateDB | HPRD:12084722CellTalkDB:27100352InnateDB:22271762IntAct:12084722HINT:12084722HINT:22271762SIGNOR:12869555CellChatDB:20064972IntAct:30458687 |
| KAPCA | P17612 | ABCA1 | O95477 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDReactome_ProtMapperPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | KEA:12196520HPRD:12196520ProtMapper:12196520PhosphoSite:12196520HPRD-phos:12196520SIGNOR:12196520 |
| CSK21 | P68400 | ABCA1 | O95477 | Yes | No | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | HPRD:15218032PhosphoSite:15218032KEA:15218032phosphoELM:15218032 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
2,261
Mass
254,302
Sequence
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV
3D Structural Models
Turn
240..245; 560..562; 582..585; 909..911; 964..966; 1000..1002; 1214..1216; 1229..1231; 1561..1563; 1568..1570; 1727..1729; 1732..1734; 1755..1759; 1846..1848; 1872..1875; 1922..1924; 1977..1979; 2197..2200
Helix
4..20; 22..44; 62..64; 66..75; 87..89; 101..117; 121..135; 200..209; 216..226; 230..233; 236..239; 253..274; 278..288; 299..308; 353..363; 369..379; 390..404; 405..409; 412..416; 419..426; 431..440; 445..453; 460..467; 484..501; 516..528; 587..590; 593..608; 631..643; 646..664; 667..674; 678..706; 715..737; 743..756; 759..767; 768..770; 773..779; 785..799; 821..845; 940..946; 968..972; 990..999; 1005..1019; 1030..1032; 1035..1045; 1065..1077; 1091..1096; 1115..1121; 1182..1190; 1218..1227; 1244..1253; 1322..1341; 1344..1350; 1352..1364; 1381..1383; 1401..1408; 1446..1449; 1505..1522; 1548..1560; 1571..1582; 1601..1617; 1644..1667; 1669..1671; 1672..1680; 1684..1690; 1695..1723; 1735..1753; 1763..1789; 1796..1807; 1811..1833; 1849..1871; 1893..1904; 1952..1960; 1981..1985; 2003..2014; 2018..2020; 2021..2030; 2042..2044; 2047..2058; 2077..2092; 2104..2109; 2128..2134; 2153..2162; 2187..2196; 2213..2223
Beta Strand
58..60; 90..92; 98..100; 212..215; 384..386; 441..444; 535..537; 541..545; 550..557; 616..621; 709..713; 782..784; 805..808; 849..851; 893..895; 899..906; 920..924; 929..933; 937..939; 948..950; 953..959; 975..978; 986..989; 1023..1025; 1052..1059; 1060..1062; 1080..1082; 1084..1087; 1099..1105; 1108..1113; 1126..1129; 1191..1193; 1195..1198; 1200..1202; 1205..1208; 1210..1213; 1239..1241; 1384..1386; 1388..1393; 1398..1400; 1414..1421; 1456..1458; 1487..1490; 1492..1494; 1496..1499; 1533..1539; 1587..1594; 1624..1626; 1628..1633; 1681..1683; 1911..1919; 1934..1936; 1940..1946; 1967..1974; 1989..1991; 2035..2037; 2038..2041; 2064..2070; 2071..2074; 2096..2100; 2112..2118; 2121..2123; 2140..2144; 2168..2170; 2173..2179; 2205..2211
3D Structure
Electron microscopy (7)
Domain & Motif Annotations
Compositional Bias
1287..1299; Acidic residues
Domain (CC)
Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Domain (FT)
899..1131; ABC transporter 1; 1912..2144; ABC transporter 2
Region
69..80; Annulus domain 1; 368..379; Annulus domain 2; 564..594; Gateway domain; 1283..1312; Disordered
Protein Families
- ABC transporter superfamily
- ABCA family
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCA family.
Clinical Relevance
Disease Involvement
AtherosclerosisDisease variantFDA approved drug targets
Biomarker
Approved; Investigative; Discontinued in Phase 1
Drug Targets
FDA approved drug targets
Drugs
N(6)-CYCLOHEXYLADENOSINEPSB36NAMODENOSONCV-1808LUF 7602COMPOUND 10 [PMID: 31306001]MRS1086FENOFIBRATE MICRONIZEDKF 17837SCPXMRS923APADENOSONMRS1132UK-432,097MRS1084[3H]ZM 241385LJ-4517PRAVASTATIN SODIUMCIFORADENANT[3H]CGS 21680CCPAATORVASTATIN CALCIUM TRIHYDRATEPENECAATL802MRS1042MRS1041THEOPHYLLINEMORINCV-1674MRS3558IMARADENANTDPCPXROSUVASTATINETRUMADENANTPROBUCOLHEMADOSCH 58261(R,S)-PHPNECA2-HEXYNYL-NECAPICLIDENOSONMRE 2029F20MRS1754MRS1191SIMVASTATINBAY 60-6583(R)-PIAKF26777XANTHINE AMINE CONGENERST-1535MRS1523BIHELICAL APOA-I MIMETIC PEPTIDE 5ACLOPIDOGRELSCH442416NECACGS 21680AB-MECAPSB-11CGS 15943APNEACYCLOPENTYLADENOSINEMETRIFUDILMRS10664-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOLDOXORUBICIN HYDROCHLORIDELUF 5981CYCLOSPORINEPRELADENANTCOMPOUND 4G [PMID: 22220592]SAKURANETINMRS1093DAUNORUBICIN LIPOSOMALLAS38096GR79236PSB-10MEFLOQUINEFK-453MRS5151ISTRADEFYLLINEMRS1088MRS1065MRE 3008F20MRS928CAFFEINEPSB603DERENOFYLLINEFLAVONECGS 24012CPFPXGS9667VISNAGINTCPAVIPADENANTGALANGINREGADENOSON ANHYDROUSCVT-6883BINODENOSONADENOSINE(S)-PIAMSX-2TOZADENANTPBF-509ROLOFYLLINETONAPOFYLLINE2-CHLOROADENOSINE
Interaction Protein
ENSG00000118137ENSG00000168807
Interaction Count
2
Interaction Dataset
intact_biogrid