Protein detail
AGRL2
Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)
Entry name AGRL2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)
Protein Function (3)
- G-protein coupled receptors:Family 2 (B) receptors
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
852..872; Helical; Name=1; 881..901; Helical; Name=2; 908..928; Helical; Name=3; 953..973; Helical; Name=4; 991..1011; Helical; Name=5; 1038..1058; Helical; Name=6; 1063..1083; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecifickidneyCell SpecificEnterocytesSingle-Nuclei Brain Specificependymal cellSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway5
Protein Function (3)
- G-protein coupled receptors:Family 2 (B) receptors
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence50
Ligand-Receptor Signaling (49)
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| 7tm_b | receptor | HPMR | No | Yes | No | Yes | No |
| latrophilin_lectomedin_7tm_b | receptor | HPMR | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| adhesion | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_b2_adhesion | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_b2_adhesion_adhesion | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_b2_adhesion_adhesion_adgrl | receptor | GPCRdb | No | Yes | No | Yes | No |
| adhesion_gpcr | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 25776846 |
Sequence, Structure & Domains11
Sequences
Length
1,459
Mass
163,349
Sequence
MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIISTTSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFEKMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHHKELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=O95490-1; Sequence=Displayed; Name=2; Synonyms=Lectomedin-1 gamma; IsoId=O95490-2; Sequence=VSP_010104, VSP_010107; Name=3; Synonyms=Lectomedin-1 beta; IsoId=O95490-3; Sequence=VSP_010104, VSP_010105, VSP_010106; Name=4; Synonyms=Lectomedin-1 alpha; IsoId=O95490-4; Sequence=VSP_010104, VSP_010107, VSP_010108, VSP_010109; Name=5; IsoId=O95490-5; Sequence=VSP_010107; Name=6; IsoId=O95490-6; Sequence=VSP_042267; Name=7; IsoId=O95490-7; Sequence=VSP_010104, VSP_042267
Alternative Sequence
595..607; Missing (in isoform 2, isoform 3, isoform 4 and isoform 7); 1034; K -> NNYRVCDGYYNTDLPG (in isoform 6 and isoform 7); 1134..1136; SRI -> DIH (in isoform 3); 1137..1459; Missing (in isoform 3); 1167..1209; Missing (in isoform 2, isoform 4 and isoform 5); 1210..1233; HSLNNARDTSAMDTLPLNGNFNNS -> LTSHGLRAHLQDLYHLELLLGQIA (in isoform 4); 1234..1459; Missing (in isoform 4)
Domain & Motif Annotations
Compositional Bias
426..441; Polar residues; 1364..1376; Polar residues
Domain (CC)
The Stachel sequence (also named stalk) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist. In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling.
Domain (FT)
41..130; SUEL-type lectin; 135..394; Olfactomedin-like; 659..837; GAIN-B
Region
422..456; Disordered; 788..837; GPS; 1358..1400; Disordered
Protein Families (2)
- G-protein coupled receptor 2 family
- Adhesion G-protein coupled receptor (ADGR) subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |