Protein detail

VNN2

Pantetheine hydrolase VNN2 (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) (Vascular non-inflammatory molecule 2) (Vanin-2)

Entry name VNN2	UniProt ID O95498	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Pantetheine hydrolase VNN2 (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) (Vascular non-inflammatory molecule 2) (Vanin-2)

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Ensembl

ENSG00000112303

Entrez Gene Symbol

VNN2

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificLate spermatids

Function & Pathway7

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Immune mediationMetabolism mediation

Relations & Evidence26

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	Yes
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	CSPA	No	No	No	Yes	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	OmniPath	No	No	No	Yes	Yes
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	Yes
cell_surface	cell_surface	OmniPath	No	No	No	Yes	Yes
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	Yes
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	Yes

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
COX18 ERLIN2 FKBP14 SUN2 VNN2	O94905 O95498 Q8N8Q8 Q9NWM8 Q9UH99	0:0:0:0:0	hu.MAP2
COX18 VNN2	O95498 Q8N8Q8	0:0	hu.MAP2
COX18 FKBP14 VNN2	O95498 Q8N8Q8 Q9NWM8	0:0:0	hu.MAP2
FKBP14 VNN2	O95498 Q9NWM8	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	38731868 40784529

Sequence, Structure & Domains8

Sequences

Length

520

Mass

58,503

Sequence

MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=O95498-1; Sequence=Displayed; Name=2; Synonyms=GPI-80 variant protein 3; IsoId=O95498-2; Sequence=VSP_038557; Name=3; Synonyms=GPI-80 variant protein 2; IsoId=O95498-3; Sequence=VSP_038558, VSP_038559; Name=4; Synonyms=GPI-80 variant protein 1; IsoId=O95498-4; Sequence=VSP_038556, VSP_038560; Name=5; Synonyms=GPI-80 variant protein 4; IsoId=O95498-5; Sequence=VSP_038554, VSP_038555; Name=6; IsoId=O95498-6; Sequence=VSP_044912

Alternative Sequence

1..53; Missing (in isoform 6); 116..119; FGHT -> SAQC (in isoform 5); 120..520; Missing (in isoform 5); 180..400; Missing (in isoform 2); 180..195; YHLYSEPQFNVPEKPE -> EVVFMHQMVPKCIIMT (in isoform 4); 180..192; YHLYSEPQFNVPE -> ETLQSVKRSFAVI (in isoform 3); 193..520; Missing (in isoform 3); 196..520; Missing (in isoform 4)

Domain & Motif Annotations

Domain (FT)

31..306; CN hydrolase

Protein Families (2)

Carbon-nitrogen hydrolase superfamily
BTD/VNN family

Sequence Similarities

Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

Supporting Publications1

PMID	Title	Abstract
37704453	VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release.	No abstract available