Protein detail

ADCY5

Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5)

Entry name ADCY5	UniProt ID O95622	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 12	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5)

Protein Class (5)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPredicted membrane proteins

Protein Function (4)

Disease related genes
Enzymes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
ENZYME proteins:Lyases

Transmembrane

196..216; Helical; 242..262; Helical; 268..288; Helical; 299..319; Helical; 325..345; Helical; 374..394; Helical; 770..790; Helical; 792..812; Helical; 836..856; Helical; 910..930; Helical; 935..955; Helical; 984..1004; Helical

Transmembrane Count

Ensembl

ENSG00000173175

Entrez Gene Symbol

ADCY5

Gene Synonym

AC5

Gene Description

Adenylate cyclase 5

Chromosome

Position

123282296-123449090

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (4)

Disease related genes
Enzymes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
ENZYME proteins:Lyases

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

KEGG (57)

Page 1 of 6

Reactome (37)

Page 1 of 4

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence31

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_surface_enzyme	cell_surface_enzyme	Surfaceome	Yes	No	No	No	No
cell_surface_enzyme	cell_surface_enzyme	OmniPath	Yes	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

Page 1 of 3Next

Regulatory Interaction Network (8)

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADCY5	O95622	CAMP	P49913	Yes	Yes	No	WangCui2007SignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:15539636 SignaLink3:16460834 SignaLink3:7935349
GNAI1	P63096	ADCY5	O95622	Yes	No	Yes	KEGG-MEDICUSSIGNORHPRDSignaLink3WangTCRcuration_SignaLink3	SIGNOR:8119955 SignaLink3:7935349 SignaLink3:23109003 SignaLink3:11376933 HPRD:9748257 SignaLink3:15539636 SignaLink3:16460834
GNAI2	P04899	ADCY5	O95622	Yes	No	Yes	KEGG-MEDICUSSIGNORSignaLink3WangTCRcuration_SignaLink3	SIGNOR:8119955 SignaLink3:7935349 SignaLink3:23109003 SignaLink3:11376933 SignaLink3:15539636 SignaLink3:16460834
GNAI3	P08754	ADCY5	O95622	Yes	No	Yes	KEGG-MEDICUSSIGNORCui2007SignaLink3CA1WangTCRcuration_SignaLink3	SIGNOR:8119955 SignaLink3:7935349 SignaLink3:23109003 SignaLink3:11376933 SignaLink3:16460834 SignaLink3:15539636 CA1:8327893
GNAZ	P19086	ADCY5	O95622	Yes	No	Yes	WangCui2007SIGNORCA1	SIGNOR:7829508 CA1:7829508
GNAL	P38405	ADCY5	O95622	Yes	Yes	No	WangSIGNOR	SIGNOR:21303898
	COMPLEX:P59768_P62873	ADCY5	O95622	Yes	No	Yes	SIGNOR	SIGNOR:9707174
GNB5	O14775	ADCY5	O95622	Yes	Yes	Yes	SIGNOR	SIGNOR:21303898

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ADCY5	O95622	2	PDB	PDB:8sl4

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry\|FACSFACSR Sequencing	1	40689422

Sequence, Structure & Domains12

Sequences

Length

1,261

Mass

138,908

Sequence

MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95622-1; Sequence=Displayed; Name=2; IsoId=O95622-2; Sequence=VSP_042914, VSP_042915

Alternative Sequence

1..28; MSGSKSVSPPGYAAQKTAAPAPRGGPEH -> MKSQKEGCCSRGDLSIQTGPGGEWAPRR (in isoform 2); 29..378; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

25..37; Basic and acidic residues; 121..132; Low complexity; 151..171; Basic and acidic residues; 178..188; Gly residues

Domain (CC)

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.

Domain (FT)

469..596; Guanylate cyclase 1; 1071..1210; Guanylate cyclase 2

Region

1..195; Disordered

Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Sequence Similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Clinical Relevance3

Disease Involvement (2)

Disease variantIntellectual disability

Drugs

CHEMBL:CHEMBL401844

Antibody (2)

HPA017730 HPA077682

Supporting Publications1

PMID	Title	Abstract
39408670	Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles.	No abstract available