Protein detail

SEM4F

Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)

Entry name SEM4F	UniProt ID O95754	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

660..680; Helical

Transmembrane Count

Ensembl

ENSG00000135622

Entrez Gene Symbol

SEMA4F

Gene Synonym (2)

SEMAMSEMAW

Gene Description

Ssemaphorin 4F

Chromosome

Position

74654228-74683853

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04360 Axon guidance

Reactome (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence35

Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
semaphorin	cell_surface_ligand	HGNC	Yes	No	No	Yes	No
semaphorin	cell_surface_ligand	Almen2009	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CHST12 CHST14 ENTPD6 LRIG1 SEMA4F	O75354 O95754 Q8NCH0 Q96JA1 Q9NRB3	0:0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains10

Sequences

Length

770

Mass

83,511

Sequence

MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O95754-1; Sequence=Displayed; Name=Short; IsoId=O95754-2; Sequence=VSP_006043

Alternative Sequence

120..274; Missing (in isoform Short)

Domain & Motif Annotations

Motif

768..770; PDZ-binding

Domain (FT)

42..510; Sema; 512..563; PSI; 580..635; Ig-like C2-type

Region

696..725; Disordered

Protein Families

Semaphorin family

Sequence Similarities

Belongs to the semaphorin family.

Clinical Relevance1

Antibody

HPA064095

Supporting Publications2

PMID	Title	Abstract
32301581	Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues.	Extracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau.
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available