Protein detail
SEM4F
Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)
Entry name SEM4F | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
660..680; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
SEMAMSEMAW
Gene Description
Ssemaphorin 4F
Chromosome
2
Position
74654228-74683853
Supporting publications (n)
2
EVMP confidence score
0.25
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (7)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence35
Ligand-Receptor Signaling (33)
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | Baccin2019 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains10
Sequences
Length
770
Mass
83,511
Sequence
MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O95754-1; Sequence=Displayed; Name=Short; IsoId=O95754-2; Sequence=VSP_006043
Alternative Sequence
120..274; Missing (in isoform Short)
Domain & Motif Annotations
Motif
768..770; PDZ-binding
Domain (FT)
42..510; Sema; 512..563; PSI; 580..635; Ig-like C2-type
Region
696..725; Disordered
Protein Families
Semaphorin family
Sequence Similarities
Belongs to the semaphorin family.
Clinical Relevance1
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 32301581 | Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. | Extracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau. |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |