Protein detail

TBCD8

TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein)

Entry name TBCD8	UniProt ID O95759	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000204634

Entrez Gene Symbol

TBC1D8

Gene Synonym (4)

AD3GRAMD8HBLP1VRP

Gene Description

TBC1 domain family member 8

Chromosome

Position

101007228-101252866

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0016020 membrane

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M17 Pid notch pathway
M255 Pid hif1 tfpathway
M66 Pid myc activ pathway

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ASB9 CKMT1A LYPLA2 TBC1D8B YKT6	O15498 O95372 P12532 Q0IIM8 Q96DX5	0:0:0:0:0	hu.MAP
MRPL50 MTERF3 NGRN PTCD1 RCC1L TBC1D8 TRUB2 YARS2	O75127 O95759 O95900 Q8N5N7 Q96E29 Q96I51 Q9NPE2 Q9Y2Z4	0:0:0:0:0:0:0:0	hu.MAP2
MRPL50 TBC1D8	O95759 Q8N5N7	0:0	hu.MAP
MRPL50 TBC1D8 THAP9	O95759 Q8N5N7 Q9H5L6	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingFlow cytometryMORPH	4	38731868 32468033 40098346 41216884

Sequence, Structure & Domains9

Sequences

Length

1,140

Mass

130,835

Sequence

MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGEGGGRLTGRLVGALDAVLDSNARVAPFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVKALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLYLSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLDEVFKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAFFRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIEKMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLVFHSTSMCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPMASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTEILAERTFRLLDDNMDQLIEFKAFVSCLDIMYNGEMNEKIKLLYRLHIPPALTENDRDSQSPLRNPLLSTSRPLVFGKPNGDAVDYQKQLKQMIKDLAKEKDKTEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQRGSSSGSCSQECGEELRASAPSPEDSVFADTGKTPQDSQAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAKINQYNLKTFEMSHQSQSELKLSNL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95759-1; Sequence=Displayed; Name=2; IsoId=O95759-2; Sequence=VSP_038340

Alternative Sequence

1..243; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1032..1043; Low complexity

Domain (CC)

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

Domain (FT)

145..212; GRAM 1; 285..353; GRAM 2; 505..692; Rab-GAP TBC

Region

1031..1070; Disordered

Clinical Relevance1

Antibody (2)

CAB015211 HPA074921

Supporting Publications1

PMID	Title	Abstract
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No abstract available