Protein detail

GPR75

Probable G-protein coupled receptor 75

Entry name GPR75	UniProt ID O95800	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Probable G-protein coupled receptor 75

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

47..67; Helical; Name=1; 87..107; Helical; Name=2; 121..141; Helical; Name=3; 161..181; Helical; Name=4; 206..226; Helical; Name=5; 319..339; Helical; Name=6; 351..371; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000119737

Entrez Gene Symbol

GPR75

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue Specificskin 1Cell SpecificBasal keratinocytes

Function & Pathway5

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

Mediation Categories (2)

Immune mediationReceptor-signaling mediation

Relations & Evidence54

Ligand-Receptor Signaling (53)

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
cytokine	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains7

Sequences

Length

540

Mass

59,359

Sequence

MNSTGHLQDAPNATSLHVPHSQEGNSTSLQEGLQDLIHTATLVTCTFLLAVIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDAFCFTFHLTSSGFIIMSLKTVAVIALHRLRMVLGKQPNRTASFPCTVLLTLLLWATSFTLATLATLKTSKSHLCLPMSSLIAGKGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRNQNYNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVVTCVIIVLSVLVCCLPLGISLVQVVLSSNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLQYIGLGFFCCKQKTRLRAMGKGNLEVNRNKSSHHETNSAYMLSPKPQKKFVDQACGPSHSKESMVSPKISAGHQHCGQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGFANSYIAMHYHTTNDLVQEYDSTSAKQIPVPSV

Domain & Motif Annotations

Compositional Bias

1..15; Polar residues

Region

1..27; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Supporting Publications3

PMID	Title	Abstract
24505114	Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.	These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4.
31588238	Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available