Protein detail
CLD1
Claudin-1 (Senescence-associated epithelial membrane protein)
Protein symbol CLD1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Claudin-1 (Senescence-associated epithelial membrane protein)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Potential drug targets
Transmembrane
8..28; Helical; 82..102; Helical; 116..136; Helical; 164..184; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
ILVASCSEMP1
Gene Description
Claudin 1
Chromosome
3
Position
190305707-190322446
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificcDC
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Potential drug targets
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M66 Pid myc activ pathway
- M5493 Wnt signaling
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | CLD1 | O95832 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:31398894 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MMP-2-CLDN1 complex | CLDN1MMP2 | O95832P08253 | 1:1 | CompleatCORUM | Compleat:HC401CORUM:2798 | 11382769 |
| MMP14-CLDN1 complex | CLDN1MMP14 | O95832P50281 | 1:1 | CompleatCORUM | Compleat:HC3367CORUM:2688 | 11382769 |
| ATE1CLDN10HLA-DQB2POU2AF1REG4RNASE13 | O95260P05538P78369Q16633Q5GAN3Q9BYZ8 | 0:0:0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37403840 |
Sequence, Structure & Domains
Sequences
Length
211
Mass
22,744
Sequence
MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
3D Structural Models
Domain & Motif Annotations
Region
192..211; Disordered; 210..211; Interactions with TJP1, TJP2, TJP3 and PATJ
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.