Protein detail

GLP2R

Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)

Entry name GLP2R	UniProt ID O95838	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

Basic Information

Protein Names

Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)

Protein Class (3)

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

Protein Function (3)

G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Family 2 (B) receptors
FDA approved drug targets:Biotech drugs

Transmembrane

174..198; Helical; Name=1; 211..235; Helical; Name=2; 262..285; Helical; Name=3; 300..321; Helical; Name=4; 340..362; Helical; Name=5; 387..405; Helical; Name=6; 418..438; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000065325

Entrez Gene Symbol

GLP2R

Gene Description

Glucagon like peptide 2 receptor

Chromosome

Position

9822206-9892099

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Tissue SpecificplacentaCell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway

Protein Function (3)

G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Family 2 (B) receptors
FDA approved drug targets:Biotech drugs

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence53

Ligand-Receptor Signaling (52)

52 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
receptor	receptor	talklr	Yes	Yes
receptor	receptor	Cellinker	Yes	Yes
receptor	receptor	scConnect	Yes	Yes
receptor	receptor	connectomeDB2020	Yes	Yes
receptor	receptor	iTALK	Yes	Yes
receptor	receptor	Almen2009	Yes	Yes
receptor	receptor	CellCellInteractions	Yes	Yes
receptor	receptor	EMBRACE	Yes	Yes
gpcr	receptor	GPCRdb	Yes	Yes
glucagon	receptor	HGNC	Yes	Yes

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting\|Flow cytometryWestern blotting	3	40730843 41307968 38207106

Sequence, Structure & Domains

Sequences

Length

553

Mass

63,001

Sequence

MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI

3D Structural Models

Turn

300..302; 437..439

Helix

167..202; 209..238; 253..256; 259..287; 303..307; 312..324; 341..370; 376..394; 399..403; 412..436; 441..451

Beta Strand

290..292; 336..338

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 2 family

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases (5)

Bowel habit change Digestive system disease Indeterminate colitis Low bone mass disorder Neonatal malabsorption syndrome

Biomarker

Phase 2; Investigative; Phase 1; Approved

Drug Targets

FDA approved drug targets

Drugs (5)

TEDUGLUTIDE FE 203799 NULL GLEPAGLUTIDE ELSIGLUTIDE

Antibody (2)

CAB022690 HPA049244

Supporting Publications1

PMID	Title	Related sentences
39318865	Stem Cell-Derived Exosomes as a Therapeutic Option for Spinal Cord Injuries; a Systematic Review and Meta-Analysis.	Additionally, MSC-derived exosome administration significantly increased the expression of the anti-inflammatory interleukin (IL)-10 and IL-4 (p<0.001 and p=0.001, respectively) and decreased the expression of the inflammatory IL-1b, IL-6, and TNF-a (p<0.0001). The administration of MSC-derived exosomes enhanced the expression of beta-tubulin III, NF200, and GAP-43, and increased the number of NeuN-positive and Nissl-positive cells, while reducing the expression of glial fibrillary acidic protein (p<0.0001).