Protein detail
GLP2R
Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)
Entry name GLP2R | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:GPCRs excl olfactory receptors
- G-protein coupled receptors:Family 2 (B) receptors
- FDA approved drug targets:Biotech drugs
Transmembrane
174..198; Helical; Name=1; 211..235; Helical; Name=2; 262..285; Helical; Name=3; 300..321; Helical; Name=4; 340..362; Helical; Name=5; 387..405; Helical; Name=6; 418..438; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Glucagon like peptide 2 receptor
Chromosome
17
Position
9822206-9892099
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- G-protein coupled receptors:GPCRs excl olfactory receptors
- G-protein coupled receptors:Family 2 (B) receptors
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| receptor | receptor | EMBRACE | No | Yes | No | Yes | No |
| gpcr | receptor | GPCRdb | No | Yes | No | Yes | No |
| glucagon | receptor | HGNC | No | Yes | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
553
Mass
63,001
Sequence
MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
3D Structural Models
Turn
300..302; 437..439
Helix
167..202; 209..238; 253..256; 259..287; 303..307; 312..324; 341..370; 376..394; 399..403; 412..436; 441..451
Beta Strand
290..292; 336..338
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 2 family
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 2; Investigative; Phase 1; Approved
Drug Targets
FDA approved drug targets