Protein detail
G6B
Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b)
Entry name G6B | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b)
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
Transmembrane
143..163; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M220 Pid caspase pathway
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
241
Mass
26,163
Sequence
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=B; IsoId=O95866-1; Sequence=Displayed; Name=A; IsoId=O95866-2; Sequence=VSP_014176; Name=C; IsoId=O95866-3; Sequence=VSP_014174; Name=D; IsoId=O95866-4; Sequence=VSP_014172; Name=E; IsoId=O95866-5; Sequence=VSP_014173; Name=F; IsoId=O95866-6; Sequence=VSP_014175; Name=G; IsoId=O95866-7; Sequence=VSP_014177
Alternative Sequence
137..241; GSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV -> ALSPPHSSTCENRAPEASKGGRAQDSRGPGPGTEPALCGSGPSSPQQAPPAVHSGPC (in isoform D); 137..180; Missing (in isoform E); 138..180; SVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRF -> ACPRNRFDHSLDLLCPPHI (in isoform C); 181..241; APLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV -> GETNSTPFSFSYMPTPHPSIPESEPLLGADTLVTFSPSFSSVPPT (in isoform F); 182..241; PLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV -> LSPPHSSTCENRAPEASKGGRAQDSRGPGPGTEPALCGSGPSSPQQAPPAVHSGPC (in isoform A); 182..241; PLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV -> LSPPHSSTCENRAPEASKGGRAQDSRGPGPGTGKGMGMGRG (in isoform G)
3D Structural Models
Turn
99..101
Beta Strand
21..25; 30..33; 67..69; 94..97; 104..106; 111..113; 118..123
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
209..214; ITIM motif; 235..240; ITIM motif
Domain (CC)
Isoform B, displayed in this entry, is the only one of the isoforms to contain both a transmembrane region and 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. The 2 ITIM motifs of isoform B are required for the inhibition of CLEC1B and GP6:FCER1G signaling and platelet activation.