Protein detail

BY55

CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]

Entry name BY55	UniProt ID O95971	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]

Protein Function (2)

Predicted secreted proteins
CD markers

Ensembl

ENSG00000117281

Entrez Gene Symbol

CD160

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Tissue SpecifickidneyCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificpericyte

Function & Pathway6

Protein Function (2)

Predicted secreted proteins
CD markers

Cellular Component (3)

Molecular Function (7)

Biological Process (3)

Reactome (2)

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence40

Ligand-Receptor Signaling (38)

38 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	CSPA	No	No	Yes	No	Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	OmniPath	No	No	Yes	No	Yes
secreted	secreted	UniProt_keyword	No	No	Yes	No	Yes
secreted	secreted	connectomeDB2020	No	No	Yes	No	Yes
secreted	secreted	OmniPath	No	No	Yes	No	Yes
cell_surface	cell_surface	Surfaceome	No	No	Yes	No	Yes
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	No	Yes
cell_surface	cell_surface	OmniPath	No	No	Yes	No	Yes
ligand	ligand	connectomeDB2020	Yes	No	Yes	No	Yes

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CD160	O95971	2	PDB	PDB:6nggPDB:6ng9

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains10

Sequences

Length

181

Mass

19,810

Sequence

MLLEPGRGCCALAILLAIVDIQSGGCINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSSGFLQEKVWVMLVTSLVALQAL

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CD160; IsoId=O95971-1; Sequence=Displayed; Name=2; Synonyms=CD160deltaIg; IsoId=O95971-2; Sequence=VSP_060018; Name=3; Synonyms=CD160-TM; IsoId=O95971-3; Sequence=VSP_060019; Name=4; Synonyms=CD160deltaIg-TM; IsoId=O95971-4; Sequence=VSP_060017

Alternative Sequence

25..181; GCINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSSGFLQEKVWVMLVTSLVALQAL -> ETGNYTVTGLKQRQHLEFSHNEGTLSSGFLQEKVWVMLVTSLVALQGMSKRAVSTPSNEGAIIFLPPWLFSRRRRLERMSRGREKCYSSPGYPQESSNQFH (in isoform 4); 25..133; Missing (in isoform 2); 180..181; AL -> GMSKRAVSTPSNEGAIIFLPPWLFSRRRRLERMSRGREKCYSSPGYPQESSNQFH (in isoform 3)

3D Structural Models

Turn

117..119

Helix

50..52; 70..72; 104..106

Beta Strand

28..36; 39..47; 54..63; 74..77; 88..101; 108..116; 122..124; 128..132; 138..141

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Domain (FT)

25..133; Ig-like V-type

Supporting Publications3

PMID	Title	Abstract
33936570	Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.	No abstract available
37670049	Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility.	No abstract available
38014595	Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.	No abstract available