Protein detail

S1PR4

Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)

Entry name S1PR4	UniProt ID O95977	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)

Protein Function (2)

G-protein coupled receptors:Lysolipids receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

51..71; Helical; Name=1; 85..105; Helical; Name=2; 118..138; Helical; Name=3; 162..182; Helical; Name=4; 207..227; Helical; Name=5; 253..273; Helical; Name=6; 289..309; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000125910

Entrez Gene Symbol

S1PR4

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Function & Pathway7

Protein Function (2)

G-protein coupled receptors:Lysolipids receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (5)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence46

Ligand-Receptor Signaling (45)

45 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
lysosphingolipid_lysophosphatidic_acid_edg_7tm_a	receptor	HPMR	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	38731868 40784529

Sequence, Structure & Domains8

Sequences

Length

384

Mass

41,623

Sequence

MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI

3D Structural Models

Helix

108..111

Beta Strand

113..116

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance1

Drugs (9)

AMISELIMOD HYDROCHLORIDE FINGOLIMOD LAURYL SULFATE FINGOLIMOD HYDROCHLORIDE CHEMBL:CHEMBL171699 CHEMBL:CHEMBL1362503 9,10-PHENANTHRENEQUINONE CHEMBL:CHEMBL579318 ISOVELLERAL CHEMBL:CHEMBL586135

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available