Protein detail
RECK
Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)
Protein symbol RECK | UniProt ID | EVMP score 0.72 |
Frequency 13 | Transmembrane count | Protein classification Plasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)
Protein Class
Plasma proteinsPredicted membrane proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
hRECKST15
Gene Description
Reversion inducing cysteine rich protein with kazal motifs
Chromosome
9
Position
36036913-36124455
Frequency
13
EVMP Score
0.72
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificleukocyte
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Metabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | Yes | Yes |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | Yes |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | Yes |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40326690 |
Sequence, Structure & Domains
Sequences
Length
971
Mass
106,457
Sequence
MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN
3D Structural Models
Helix
211..218; 223..235; 239..249; 259..269
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Repeat
37..84; Knot 1; 104..141; Knot 2; 151..197; Knot 3; 216..263; Knot 4; 292..338; Knot 5
Domain (CC)
The Kazal-like domains mediate the serine protease inhibitor activity.
Domain (FT)
627..673; Kazal-like 1; 698..752; Kazal-like 2; 753..789; Kazal-like 3
Region
37..338; 5 X Knot repeats
Protein Families
RECK family
Sequence Similarities
Belongs to the RECK family.