Protein detail
DRC4
Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)
Entry name DRC4 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DRC4GAS11
Gene Description
Growth arrest specific 8
Chromosome
16
Position
90019629-90044975
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificmonocytesSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M16801 Sig regulation of the actin cytoskeleton by rho gtpases
- M5193 Sig chemotaxis
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37700095 |
Sequence, Structure & Domains
Sequences
Length
478
Mass
56,356
Sequence
MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95995-1; Sequence=Displayed; Name=2; IsoId=O95995-2; Sequence=VSP_054805
Alternative Sequence
1..25; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
1..12; Basic residues
Coiled Coil
242..427
Region
1..114; Regulates microtubule-binding; 1..33; Disordered; 115..258; Microtubule-binding; 357..478; Interaction with SMO
Protein Families
DRC4 family
Sequence Similarities
Belongs to the DRC4 family.