Protein detail
DRC4
Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)
Entry name DRC4 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DRC4GAS11
Gene Description
Growth arrest specific 8
Chromosome
16
Position
90019629-90044975
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificmonocytesSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- Predicted intracellular proteins
Cellular Component (10)
Molecular Function (4)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M16801 Sig regulation of the actin cytoskeleton by rho gtpases
- M5193 Sig chemotaxis
Mediation Categories
Receptor-signaling mediation
Relations & Evidence7
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | ||||
| ecm | ecm | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37700095 |
Sequence, Structure & Domains
Sequences
Length
478
Mass
56,356
Sequence
MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95995-1; Sequence=Displayed; Name=2; IsoId=O95995-2; Sequence=VSP_054805
Alternative Sequence
1..25; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
1..12; Basic residues
Coiled Coil
242..427
Region
1..114; Regulates microtubule-binding; 1..33; Disordered; 115..258; Microtubule-binding; 357..478; Interaction with SMO
Protein Families
DRC4 family
Sequence Similarities
Belongs to the DRC4 family.
Clinical Relevance
Disease Involvement (2)
CiliopathyPrimary ciliary dyskinesia
Related Diseases
Interaction Protein
ENSG00000171446
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |