Protein detail
ADH1G
Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma)
Entry name ADH1G | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 5 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma)
Protein Class (6)
EnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ADH3
Gene Description
Alcohol dehydrogenase 1C (class I), gamma polypeptide
Chromosome
4
Position
99336497-99352746
Supporting publications (n)
5
EVMP confidence score
0.38
Fluorescence & Localization1
Blood Cell Specificnaive B-cell
Function & Pathway7
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (9)
- hsa00010 Glycolysis / Gluconeogenesis
- KEGG:hsa00071 Fatty acid degradation
- KEGG:hsa00350 Tyrosine metabolism
- KEGG:hsa00620 Pyruvate metabolism
- KEGG:hsa00830 Retinol metabolism
- KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450
- KEGG:hsa00982 Drug metabolism - cytochrome P450
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04936 Alcoholic liver disease
Reactome (6)
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence6
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains9
Sequences
Length
375
Mass
39,868
Sequence
MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF
3D Structural Models
Turn
142..144; 186..188; 259..261; 285..287
Helix
48..54; 102..105; 155..157; 167..170; 171..174; 176..185; 203..214; 227..229; 230..235; 244..246; 251..258; 273..282; 307..310; 320..322; 325..337; 344..346; 353..355; 356..364
Beta Strand
8..15; 23..29; 36..45; 62..65; 69..77; 89..92; 99..101; 117..119; 131..133; 136..139; 147..154; 158..160; 195..199; 218..223; 239..242; 262..268; 289..292; 302..304; 314..317; 347..352; 369..374
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Zinc-containing alcohol dehydrogenase family
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family.
Clinical Relevance4
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (45)
FIRUGLIPELCISPLATINCOMPOUND 3A [PMID: 21444206](R)-N-OLEOYLTYROSINOLLYSOPHOSPHATIDYLINOSITOL1-STEAROYL-LYSOPHOSPHATIDYLCHOLINEOLVANILN-OLEOYLDOPAMINECOMPOUND 1 [PMID: 21939274]PALMIDROLYH18968NALTREXONECYCLOPHOSPHAMIDE ANHYDROUSPSN632408OLEOYL-LYSOPHOSPHATIDYLCHOLINEJNJ-38431055COMPOUND 29A [PMID: 21444206]COMPOUND 42 [PMID: 22545772]1-PALMITOYL-LYSOPHOSPHATIDYLCHOLINEFOMEPIZOLECOMPOUND 36 [PMID: 21273063]COMPOUND 36J [PMID: 21536438]AS1907417AR2314532-OLEOYL GLYCEROLLYSOPHOSPHATIDYLETHANOLAMINECOMPOUND 1 [PMID: 21273063]NITREFAZOLECOMPOUND 3 [PMID: 21310611](S)-N-OLEOYLTYROSINOLAS15359071-OLEOYL GLYCEROLN-OLEOYLETHANOLAMIDETRETINOINCOMPOUND 20F [PMID: 21536438]SEACOMPOUND 3J [PMID: 21444206]COMPOUND 2 [PMID: 21939274]PSN375963COMPOUND 8G [PMID: 21444206]COMPOUND 23 [PMID: 21444206]APD668MBX-2982COMPOUND 58 [PMID: 21273063]AS1269574
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No abstract available |