Protein detail
EGFR
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Protein symbol EGFR | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteinsTransporters |
Basic Information
Protein Names
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteinsTransporters
Protein Function
- Human disease related genes:Cancers:Cancers of the lung and pleura
- Human disease related genes:Cancers:Head and neck cancers
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Human disease related genes:Cancers:Cancers of the urinary system
- FDA approved drug targets:Biotech drugs
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Human disease related genes:Immune system diseases:Other immune system diseases
- Cancer-related genes:Mutated cancer genes
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
- Cancer-related genes:Mutational cancer driver genes
- ENZYME proteins:Transferases
- RAS pathway related proteins
- Kinases:Tyr protein kinases
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Cancers:Cancers of the digestive system
- Transporters:Accessory Factors Involved in Transport
Transmembrane
646..668; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ERBBERBB1ERRP
Gene Description
Epidermal growth factor receptor
Chromosome
7
Position
55019017-55211628
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function
- Human disease related genes:Cancers:Cancers of the lung and pleura
- Human disease related genes:Cancers:Head and neck cancers
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Human disease related genes:Cancers:Cancers of the urinary system
- FDA approved drug targets:Biotech drugs
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Human disease related genes:Immune system diseases:Other immune system diseases
- Cancer-related genes:Mutated cancer genes
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
- Cancer-related genes:Mutational cancer driver genes
- ENZYME proteins:Transferases
- RAS pathway related proteins
- Kinases:Tyr protein kinases
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Cancers:Cancers of the digestive system
- Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005768 endosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0009925 basal plasma membrane
- GO:0009986 cell surface
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030054 cell junction
- GO:0030669 clathrin-coated endocytic vesicle membrane
- GO:0031901 early endosome membrane
- GO:0031965 nuclear membrane
- GO:0032587 ruffle membrane
- GO:0032991 protein-containing complex
- GO:0043235 receptor complex
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0070435 Shc-EGFR complex
- GO:0097060 synaptic membrane
- GO:0097489 multivesicular body, internal vesicle lumen
- GO:0097708 intracellular vesicle
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0001618 virus receptor activity
- GO:0003682 chromatin binding
- GO:0003690 double-stranded DNA binding
- GO:0004709 MAP kinase kinase kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004714 transmembrane receptor protein tyrosine kinase activity
- GO:0004888 transmembrane signaling receptor activity
- GO:0005006 epidermal growth factor receptor activity
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0019899 enzyme binding
- GO:0019900 kinase binding
- GO:0019901 protein kinase binding
- GO:0019903 protein phosphatase binding
- GO:0030296 protein tyrosine kinase activator activity
- GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
- GO:0031625 ubiquitin protein ligase binding
- GO:0042802 identical protein binding
- GO:0045296 cadherin binding
- GO:0048408 epidermal growth factor binding
- GO:0051015 actin filament binding
- GO:0051117 ATPase binding
Biological Process
KEGG
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa03272 Virion - Hepatitis viruses
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04540 Gap junction
- KEGG:hsa04630 JAK-STAT signaling pathway
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04915 Estrogen signaling pathway
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05160 Hepatitis C
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05207 Chemical carcinogenesis - receptor activation
- KEGG:hsa05208 Chemical carcinogenesis - reactive oxygen species
- KEGG:hsa05210 Colorectal cancer
- KEGG:hsa05212 Pancreatic cancer
- KEGG:hsa05213 Endometrial cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05215 Prostate cancer
- KEGG:hsa05218 Melanoma
- KEGG:hsa05219 Bladder cancer
- KEGG:hsa05223 Non-small cell lung cancer
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
- KEGG:hsa05230 Central carbon metabolism in cancer
- KEGG:hsa05231 Choline metabolism in cancer
- KEGG:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Reactome
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5637810 constitutive signaling by egfrviii
- R-hsa-1236382 constitutive signaling by ligand responsive egfr cancer variants
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9924644 developmental lineages of the mammary gland
- R-hsa-9927432 developmental lineage of mammary gland myoepithelial cells
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-8863795 downregulation of erbb2 signaling
- R-hsa-182971 egfr downregulation
- R-hsa-212718 egfr interacts with phospholipase c gamma
- R-hsa-2179392 egfr transactivation by gastrin
- R-hsa-8847993 erbb2 activates ptk6 signaling
- R-hsa-6785631 erbb2 regulates cell motility
- R-hsa-8939211 esr mediated signaling
- R-hsa-9634638 estrogen dependent nuclear events downstream of esr membrane signaling
- R-hsa-9009391 extra nuclear estrogen signaling
- R-hsa-180292 gab1 signalosome
- R-hsa-881907 gastrin creb signalling pathway via pkc and mapk
- R-hsa-1963640 grb2 events in erbb2 signaling
- R-hsa-416476 g alpha q signalling events
- R-hsa-9609690 hcmv early events
- R-hsa-9609646 hcmv infection
- R-hsa-5663205 infectious disease
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-373760 l1cam interactions
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-199991 membrane trafficking
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-9675108 nervous system development
- R-hsa-9013507 notch3 activation and transmission of signal to the nucleus
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-1963642 pi3k events in erbb2 signaling
- R-hsa-8857538 ptk6 promotes hif1a stabilization
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820960 respiratory syncytial virus rsv attachment and entry
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-180336 shc1 events in egfr signaling
- R-hsa-1250196 shc1 events in erbb2 signaling
- R-hsa-177929 signaling by egfr
- R-hsa-1643713 signaling by egfr in cancer
- R-hsa-1227986 signaling by erbb2
- R-hsa-9665348 signaling by erbb2 ecd mutants
- R-hsa-1227990 signaling by erbb2 in cancer
- R-hsa-1236394 signaling by erbb4
- R-hsa-372790 signaling by gpcr
- R-hsa-157118 signaling by notch
- R-hsa-9012852 signaling by notch3
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-8848021 signaling by ptk6
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-445144 signal transduction by l1
- R-hsa-8866910 tfap2 ap 2 family regulates transcription of growth factors and their receptors
- R-hsa-8864260 transcriptional regulation by the ap 2 tfap2 family of transcription factors
- R-hsa-5653656 vesicle mediated transport
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
217 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EGFR | CAMK2A | Q9UQM7 | S | 1,120 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:10347170ProtMapper:10347170SIGNOR:10347170 |
| EGFR | MAPK3 | P27361 | T | 693 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15302935SIGNOR:1651322KEA:2543683KEA:1651323KEA:91332050KEA:3138233phosphoELM:1939237KEA:17081983KEA:15901825KEA:1939237KEA:17192257KEA:17570479ProtMapper:1651322KEA:2115882 |
| EGFR | MAPK1 | P28482 | T | 693 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15302935SIGNOR:1651322KEA:2543683KEA:1651323KEA:91332050KEA:3138233phosphoELM:1939237KEA:17081983KEA:15901825KEA:1939237KEA:17192257ProtMapper:1651322KEA:2115882 |
| EGFR | CDK1 | P06493 | S | 1,026 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15302935phosphoELM:8360196KEA:15901825ProtMapper:8360196SIGNOR:8360196ProtMapper:28150246KEA:8360196 |
| EGFR | PRKCA | P17252 | T | 678 | phosphorylation | BEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15302935KEA:2987962ProtMapper:10816576ProtMapper:15212693KEA:6090944KEA:2984676KEA:3379075SIGNOR:10816576phosphoELM:1860884phosphoELM:6090944KEA:1860884KEA:7805884KEA:85012702ProtMapper:20888375 |
| EGFR | PRKD1 | Q15139 | T | 678 | phosphorylation | dbPTMSparser_ProtMapperProtMapper | dbPTM:10523301 |
| EGFR | PRKD1 | Q15139 | T | 693 | phosphorylation | dbPTMREACH_ProtMapperSparser_ProtMapperProtMapper | dbPTM:17192257ProtMapper:26465157dbPTM:10523301dbPTM:18220336dbPTM:17081983dbPTM:18691976dbPTM:19369195dbPTM:16083266dbPTM:15302935dbPTM:19413330dbPTM:18669648dbPTM:3138233 |
| EGFR | PTPRJ | Q12913 | Y | 1,197 | dephosphorylation | SIGNORDEPOD | SIGNOR:19836242DEPOD:19836242 |
| EGFR | PTPRJ | Q12913 | Y | 1,092 | dephosphorylation | SIGNORDEPOD | SIGNOR:19836242DEPOD:19836242 |
| EGFR | PTPRJ | Q12913 | Y | 1,069 | dephosphorylation | SIGNORDEPOD | SIGNOR:19836242DEPOD:19836242 |
Ligand-Receptor Signaling
80 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | Kirouac2010 | No | Yes | Yes | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
153 records.
Protein Complex Composition
40 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CIN85-CBL-SH3GL2-EGFR complexEGF stimulated | CBLEGFRQ3V639SH3KBP1 | P00533P22681Q3V639Q96B97 | 0:0:0:0 | CORUM | CORUM:2454 | 11894095 |
| CIN85-CBL-SH3GL2-EGFR complexEGF stimulated | CBLEGFRSH3GL2SH3KBP1 | P00533P22681Q96B97Q99962 | 1:1:1:1 | Compleat | Compleat:HC327 | 11894095 |
| EGFR-CBL-GRB2 complex | CBLEGFRGRB2 | P00533P22681P62993 | 1:1:1 | CompleatCORUM | Compleat:HC394CORUM:2542 | 15782196 |
| Egfr-Grb2-mSos1 complexEGF stimulated | EGFRERBB4GRB2SOS1SOS2 | P00533P62993Q07889Q07890Q15303 | 1:1:1:1:1 | Compleat | Compleat:HC2674 | 8940013 |
| Multiprotein complex (monoubiquitination) | CBLBEGFRSH3KBP1UBB | P00533P0CG47Q13191Q96B97 | 1:1:1:1 | Compleat | Compleat:HC3629 | 12218189 |
| Multiprotein complex (monoubiquitination) | CBLBEGFRQ5U5U6SH3KBP1 | P00533Q13191Q5U5U6Q96B97 | 0:0:0:0 | CORUM | CORUM:2453 | 12218189 |
| PARK2-EPS15-EGFR complex | EGFREPS15PRKN | O60260P00533P42566 | 0:0:0 | CORUM | CORUM:6036 | 16862145 |
| RIN1-STAM2-EGFR complexEGF stimulated | EGFRRIN1STAM2 | O75886P00533Q13671 | 1:1:1 | CompleatCORUM | Compleat:HC3638CORUM:3678 | 17403676 |
| SH3KBP1-CBLB-EGFR complex | CBLBEGFRSH3KBP1 | P00533Q13191Q96B97 | 1:1:1 | CompleatCORUM | CORUM:5171Compleat:HC1651 | 12177062 |
| SNX complex (SNX1SNX1aSNX2SNX4EGFR) | EGFRSNX1SNX2SNX4 | O60749O95219P00533Q13596 | 1:1:1:1 | CompleatCORUM | CORUM:1095Compleat:HC1893 | 9819414 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 1 | 38609899 |
Sequence, Structure & Domains
Sequences
Length
1,210
Mass
134,277
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p170; IsoId=P00533-1; Sequence=Displayed; Name=2; Synonyms=p60, Truncated, TEGFR; IsoId=P00533-2; Sequence=VSP_002887, VSP_002888; Name=3; Synonyms=p110; IsoId=P00533-3; Sequence=VSP_002889, VSP_002890; Name=4; IsoId=P00533-4; Sequence=VSP_002891, VSP_002892
Alternative Sequence
404..405; FL -> LS (in isoform 2); 406..1210; Missing (in isoform 2); 628..705; CTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLR -> PGNESLKAMLFCLFKLSSCNQSNDGSVSHQSGSPAAQESCLGWIPSLLPSEFQLGWGGCSHLHAWPSASVIITASSCH (in isoform 3); 628; C -> S (in isoform 4); 629..1210; Missing (in isoform 4); 706..1210; Missing (in isoform 3)
3D Structural Models
Turn
114..116; 245..247; 272..275; 296..298; 340..342; 353..355; 380..383; 433..435; 734..736; 771..773; 859..865; 909..911; 914..917; 992..998; 999..1003
Helix
44..55; 77..81; 101..103; 159..161; 164..166; 170..173; 195..197; 228..230; 343..345; 356..359; 373..377; 389..397; 418..420; 472..474; 477..480; 496..501; 520..522; 633..635; 648..669; 679..684; 685..687; 709..711; 753..767; 798..804; 806..808; 811..830; 840..842; 856..858; 866..868; 878..880; 883..888; 893..908; 920..922; 923..928; 941..950; 955..957; 961..972; 975..977; 984..986; 1013..1016
Beta Strand
40..43; 60..69; 84..87; 89..93; 117..122; 125..129; 145..152; 183..185; 199..204; 211..214; 217..221; 223..227; 236..238; 240..244; 248..256; 259..263; 267..271; 276..279; 285..287; 290..294; 299..301; 303..305; 306..310; 313..315; 318..320; 323..325; 330..332; 336..338; 349..351; 363..367; 369..371; 400..403; 405..407; 436..442; 458..464; 481..483; 488..494; 508..510; 515..519; 523..526; 531..533; 534..537; 540..546; 548..551; 554..557; 560..562; 566..568; 570..575; 578..587; 590..594; 597..602; 606..611; 615..619; 622..624; 629..632; 643..646; 671..673; 688..692; 694..697; 703..706; 712..720; 722..731; 740..749; 777..781; 783..785; 787..791; 794..797; 843..847; 850..853; 871..873; 875..877; 937..939; 951..953; 1004..1010; 1068..1070; 1091..1094
3D Structure
Electron microscopy (17); NMR spectroscopy (6); X-ray crystallography (328)
Domain & Motif Annotations
Compositional Bias
1104..1115; Polar residues; 1128..1137; Polar residues
Repeat
75..300; Approximate; 390..600; Approximate
Domain (FT)
712..979; Protein kinase
Region
688..704; Important for dimerization, phosphorylation and activation; 1097..1137; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- EGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Angina pectorisBrain cancerBreast cancerCerebral ischaemiaChronic painColon cancerColorectal cancerCryptosporidiosisDiabetic foot ulcerDiffuse large B-cell lymphomaDigestive system diseaseEsophageal cancerGram-positive bacterial infectionHead and neck cancerHepatitis virus infectionHypopharyngeal cancerIntracerebral haemorrhageIschemiaLiver cancerLung cancerLymphomaMalignant mesenchymal neoplasmMature B-cell leukaemiaMelanomaMetastatic biliary tract neoplasmsMetastatic lymph node neoplasmMyelodysplastic syndromeNasopharyngeal cancerNon-small-cell lung cancerPancreatic cancerPsoriasisRenal cell carcinomaSkin postprocedural disorderSolid tumour/cancerSpinal cord/cranial nerve neoplasmStomach cancerTesticular cancerUnspecific body region injuryUrethral cancer
Biomarker
Approved; Phase 3; Investigative; Phase 2; Terminated; Discontinued in Phase 2; Patented; Phase 1/2; Phase 1; Phase 2/3; Discontinued in Phase 1
Drug Targets
FDA approved drug targets
Drugs
GW843682XEPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORNERATINIB MALEATEIMGATUZUMABCHEMBL:CHEMBL29197NIMOTUZUMABOSIMERTINIBNULLAFATINIBNIVOLUMABAGERAFENIBCETUXIMABMITOGEN-ACTIVATED PROTEIN KINASE KINASE INHIBITORGEFITINIBPF-05230907IPILIMUMABFUTUXIMABBMS-599626MAB-425BDTX189RITUXIMABCANERTINIBTOZASERTIBCENISERTIBAEE788ERLOTINIBZALUTUMUMABLAZERTINIBPANITUMUMABRIBAVIRINCEMIPLIMAB-RWLCTEPOTINIBMOMELOTINIBVARLITINIBAV-412MULTIKINASE INHIBITOR AEE788BARASERTIB-HQPALIDOCAINEROCILETINIBMAVELERTINIBATEZOLIZUMABFLUOROURACILPACLITAXELLOMUSTINELAPATINIBAFATINIB DIMALEATEMETHYLCURCUMINGO-6976RAMUCIRUMABMM-151DEHYDRATED ALCOHOLMOBOCERTINIBCUDC-101PAN-HER KINASE INHIBITOR AC480DEPATUXIZUMABANTI-MET MONOCLONAL ANTIBODY MIXTURE SYM015ANTI-EGFR MONOCLONAL ANTIBODY SYN004ICOTINIBBRIGATINIBEMB-01IMATINIBERLOTINIB HYDROCHLORIDEAZD-4769ZATUXIMABPELITINIBPIMURUTAMABDACOMITINIB ANHYDROUSTHELIATINIBOLMUTINIBAUMOLERTINIBALISERTIBVATALANIBPACRITINIBCHEMBL:CHEMBL1358137PD 174265NVP-TAE684LEUCOVORIN CALCIUMNECITUMUMABDURVALUMABPD-168393CARBOPLATINSIROLIMUSMP-412CANERTINIB DIHYDROCHLORIDEMOBOCERTINIB SUCCINATEVANDETANIBROGARATINIBCETUXIMAB SAROTALOCAN SODIUMTESEVATINIBCHEMBL:CHEMBL219557DULIGOTUZUMABLAPRITUXIMAB EMTANSINESTO609AEE-788SOTRASTAURINPEGINTERFERON ALFA-2AURACILSORAFENIBINDIUM-111YUANHUADINEANTI-ERBB3 MONOCLONAL ANTIBODY AV-203TUCATINIBALLITINIBRG-7160EPITINIBPF-06459988GC1118CHEMBL:CHEMBL1077773ANTI-EGFR/HER2/HER3 MONOCLONAL ANTIBODY MIXTURE SYM013GRACILIN JMLN-8054OSIMERTINIB MESYLATEAMIVANTAMAB-VMJWNERATINIBPEMBROLIZUMABPEMETREXED DISODIUMEPIDERMAL GROWTH FACTORTARLOXOTINIBBMS-690514MATUZUMABALFLUTINIBRUSERONTINIBCURCUMINPEGINTERFERON ALFA-2BCYC-116FALNIDAMOLTALAZOPARIBALOE-EMODINMDX-447POZIOTINIBANTI-EGFRVIII ANTIBODY DRUG CONJUGATE AMG 595AZD-3759SAPITINIBGELDANAMYCINDEPATUXIZUMAB MAFODOTINANTI-EGFR MONOCLONAL ANTIBODY GT-MAB 5.2-GEXS-222611NAZARTINIBCIPATINIBCRIZOTINIBNAQUOTINIBRINDOPEPIMUTPKI166SERIBANTUMABJNJ-26483327AG1478ILORASERTIBANTI-MET/EGFR MONOCLONAL ANTIBODY LY3164530PATRITUMABTOMUZOTUXIMABPUQUITINIBZIPALERTINIBRG-1530MODOTUXIMABANTI-PD1 MONOCLONAL ANTIBODYANTI-PD-L1 MONOCLONAL ANTIBODYFUTUXIMAB/MODOTUXIMAB MIXTURETAMATINIBANTI-EGFRVIII IMMUNOTOXIN MR1-1TAK-285NITROGLYCERINBEVACIZUMAB-AWWBSB202190REGORAFENIBABIVERTINIB MALEATEKBP5209PLUMBAGINABIVERTINIBTREMELIMUMABCHEMBL:CHEMBL1078000DORAMAPIMODICOTINIB HYDROCHLORIDEPYROTINIBCEP-11981ANTI-EGFR MONOCLONAL ANTIBODY EMD 55900CISPLATINPD-0166285CETUXIMAB SAROTALOCANSTAUROSPORINEDIMETHYLCURCUMINTAK-715SIMOTINIBGRACILIN AIBRUTINIB
Antibody
Interaction Protein
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
Interaction Count
187
Interaction Dataset
intact_biogrid