Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class (8)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificCytotrophoblasts

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence157

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition (144)

144 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CAB39 CAB39L RPS6KB1 STK11 STRADA STRADB	P23443 Q15831 Q7RTN6 Q9C0K7 Q9H9S4 Q9Y376	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6633
ADAM17 PTPN3	P26045 P78536	1:1	PDB	PDB:8cqy
ADAMTSL1 B3GLCT CFP	P27918 Q6Y288 Q8N6G6	0:0:0	hu.MAP2
ADAM17 TIMP3	P35625 P78536	1:1	PDB	PDB:3cki
ADA2 GSS PSMF1 PSMG2 PSMG3 PSMG4	P48637 Q5JS54 Q92530 Q969U7 Q9BT73 Q9NZK5	0:0:0:0:0:0	hu.MAP2
ADA2 GSS MRI1	P48637 Q9BV20 Q9NZK5	0:0:0	hu.MAP
CAB39 CAB39L MVD NADK2 STK11 STRADA STRADB	P53602 Q15831 Q4G0N4 Q7RTN6 Q9C0K7 Q9H9S4 Q9Y376	0:0:0:0:0:0:0	hu.MAP2
ADAR	P55265	3	PDB	PDB:9b84PDB:9b89PDB:2acjPDB:3irrPDB:5zu1PDB:3irqPDB:9b83PDB:1qbjPDB:3f23PDB:3f22PDB:7zlqPDB:2gxbPDB:7zj1PDB:3f21PDB:5zupPDB:5zuo
ADAR USP38	P55265 Q8NB14	0:0	hu.MAP2
ADAM8	P78325	4	PDB	PDB:4dd8

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains10

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families (2)

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance6

Disease Involvement (4)

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases (6)

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody (4)

HPA001399 CAB004307 HPA023884 CAB080432

Supporting Publications1

PMID	Title	Abstract
38892056	ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.	Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.