Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class (8)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Cell SpecificCytotrophoblasts

Function & Pathway

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence157

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Receiver
receptor	receptor	GO_Intercell	Yes
receptor	receptor	OmniPath	Yes
extracellular	extracellular	DGIdb
extracellular	extracellular	OmniPath
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes		HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition (144)

144 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FTSJ1 THADA	Q6YHU6 Q9UET6	1:1	PDB	PDB:8y2o
C5orf24 CHFR DNAAF8 DTX3 PKNOX2 STRADA	Q7RTN6 Q7Z6I8 Q8IYS4 Q8N9I9 Q96EP1 Q96KN3	0:0:0:0:0:0	hu.MAP2
C5orf24 CHFR DTX3 STRADA	Q7RTN6 Q7Z6I8 Q8N9I9 Q96EP1	0:0:0:0	hu.MAP2
C5orf24 CHFR DTX3 PKNOX2 STRADA	Q7RTN6 Q7Z6I8 Q8N9I9 Q96EP1 Q96KN3	0:0:0:0:0	hu.MAP2
C5orf24 CAB39L CHFR DTX3 STRADA	Q7RTN6 Q7Z6I8 Q8N9I9 Q96EP1 Q9H9S4	0:0:0:0:0	hu.MAP2
CAB39L STRADA	Q7RTN6 Q9H9S4	0:0	hu.MAPhu.MAP2
CAB39 STRADA	Q7RTN6 Q9Y376	1:1	PDB	PDB:3gniPDB:1upk
ADAT2	Q7Z6V5	4	PDB	PDB:3dh1
ADAT2 ADAT3	Q7Z6V5 Q96EY9	0:0	hu.MAPhu.MAP2
ADA2	Q9NZK5	2	PDB	PDB:3lgdPDB:3lgg

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families (2)

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance

Disease Involvement (4)

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases (8)

Hereditary hemolytic anemia SCID Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody (4)

HPA001399 CAB004307 HPA023884 CAB080432

Supporting Publications1

PMID	Title	Related sentences
38892056	ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.	Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.