Protein detail
ADA
Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
Entry name ADA | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
Protein Class
Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ADA1
Gene Description
Adenosine deaminase
Chromosome
20
Position
44584896-44652252
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCytotrophoblasts
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA | P00813 | AA1R | P30542 | Yes | Yes | No | HPRDSPIKE_LCSIGNOR | HPRD:12150791HPRD:9247966SIGNOR:18680557SPIKE_LC:16713569 |
Protein Complex Composition
144 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FTSJ1THADA | Q6YHU6Q9UET6 | 1:1 | PDB | PDB:8y2o | ||
| C5orf24CHFRDNAAF8DTX3PKNOX2STRADA | Q7RTN6Q7Z6I8Q8IYS4Q8N9I9Q96EP1Q96KN3 | 0:0:0:0:0:0 | hu.MAP2 | |||
| C5orf24CHFRDTX3STRADA | Q7RTN6Q7Z6I8Q8N9I9Q96EP1 | 0:0:0:0 | hu.MAP2 | |||
| C5orf24CHFRDTX3PKNOX2STRADA | Q7RTN6Q7Z6I8Q8N9I9Q96EP1Q96KN3 | 0:0:0:0:0 | hu.MAP2 | |||
| C5orf24CAB39LCHFRDTX3STRADA | Q7RTN6Q7Z6I8Q8N9I9Q96EP1Q9H9S4 | 0:0:0:0:0 | hu.MAP2 | |||
| CAB39LSTRADA | Q7RTN6Q9H9S4 | 0:0 | hu.MAPhu.MAP2 | |||
| CAB39STRADA | Q7RTN6Q9Y376 | 1:1 | PDB | PDB:3gniPDB:1upk | ||
| ADAT2 | Q7Z6V5 | 4 | PDB | PDB:3dh1 | ||
| ADAT2ADAT3 | Q7Z6V5Q96EY9 | 0:0 | hu.MAPhu.MAP2 | |||
| ADA2 | Q9NZK5 | 2 | PDB | PDB:3lgdPDB:3lgg |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
363
Mass
40,764
Sequence
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
3D Structural Models
Turn
92..94; 172..176
Helix
18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362
Beta Strand
11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Region
126..143; Required for binding to DDP4
Protein Families
- Metallo-dependent hydrolases superfamily
- Adenosine and AMP deaminases family
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID
Related Diseases
Biomarker
Approved; Preregistration; Phase 3
Drug Targets
FDA approved drug targets
Drugs
LEVODOPAMETHYLMERCAPTOPURINE RIBOSIDEANTIMALARIAL AGENTMETHOTREXATEDIFFERENTIATION INDUCERNULLRECOMBINANT PROTHYMOSIN ALPHAASPIRINFLUDARABINECLADRIBINEH2O2PENTOSTATINCOBALTCORDYCEPINELAPEGADEMASE-LVLRCOFORMYCINTILARGININEDIDEOXYADENOSINERECOMBINANT INTERLEUKINSELENIUMGARLICAMITRIPTYLINE HYDROCHLORIDEHYDROCORTISONE BUTYRATEELAPEGADEMASE