Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein symbol ADA	UniProt ID P00813	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificCytotrophoblasts

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition

144 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PCAF complex	KAT2B SUPT3H TADA2A TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP	O75478 O75486 O75528 O75529 Q12962 Q16514 Q16594 Q92831 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1	CORUMSPIKECompleatComplexPortal	Compleat:HC1269CORUM:471intact:EBI-12741250	9885574 17694077 14755292 9674425 9880483 10637607
PCAF complex	KAT2B TADA2A TAF10 TAF12 TAF9 TRRAP	O75478 Q12962 Q16514 Q16594 Q92831 Q9Y4A5	1:1:1:1:1:1	Compleat	Compleat:HC2267	9674425 9885574 18669648
PCAF-containing ATAC complex	DR1 KAT14 KAT2B MBIP SGF29 TADA2A TADA3 WDR5 YEATS2 ZZZ3	O75478 O75528 P61964 Q01658 Q8IYH5 Q92831 Q96ES7 Q9H8E8 Q9NS73 Q9ULM3	1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-13639399	19936620 22055187 26468280 19103755 14755292 18838386 20562830
SAGA complex	ATXN7 ATXN7L3 ENY2 KAT2A KAT2B SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF10 TAF12 TAF1A TAF2 TAF5L TAF6L TAF8 TAF9 TRRAP USP22	O15265 O75486 O75528 O75529 O94864 Q12962 Q14CW9 Q15573 Q16514 Q16594 Q6P1X5 Q7Z7C8 Q86TJ2 Q8NEM7 Q92830 Q92831 Q96BN2 Q96ES7 Q9NPA8 Q9UPT9 Q9Y4A5 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C465
SAGA complexGCN5-linked	ADA ATXN7L1 ATXN7L2 ATXN7L3 KAT2A SGF29 SUPT20H SUPT3H SUPT7L TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TAF9B TRRAP USP22	O75486 O75528 O75529 O94864 P00813 Q12962 Q14CW9 Q16514 Q16594 Q5T6C5 Q86TJ2 Q8NEM7 Q92830 Q96ES7 Q9HBM6 Q9ULK2 Q9UPT9 Q9Y4A5 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	CORUM	CORUM:6643	26468280
SAGA complexKAT2A variant	ATXN7 ATXN7L3 ENY2 KAT2A SF3B3 SF3B5 SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22	O15265 O75486 O75528 O75529 O94864 Q12962 Q14CW9 Q15393 Q16514 Q16594 Q86TJ2 Q8NEM7 Q92830 Q96BN2 Q96ES7 Q9BWJ5 Q9NPA8 Q9UPT9 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-27019609	15115762 18250150 33004486 19114550 11564863 18936164 32140746 14755292 28964624 25111486 18206972 27185460 34112237 32616828
SAGA complexKAT2B variant	ATXN7 ATXN7L3 ENY2 KAT2B SF3B3 SF3B5 SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22	O15265 O75486 O75528 O75529 O94864 Q12962 Q14CW9 Q15393 Q16514 Q16594 Q86TJ2 Q8NEM7 Q92831 Q96BN2 Q96ES7 Q9BWJ5 Q9NPA8 Q9UPT9 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-27025975	15115762 18250150 33004486 19114550 11564863 18936164 32140746 14755292 28964624 25111486 18206972 27185460 34112237 32616828
SAGA-type complex	HCFC1 SGF29 SUPT20H TADA2B USP22	P51610 Q86TJ2 Q8NEM7 Q96ES7 Q9UPT9	1:1:1:1:1	Compleat	Compleat:HC3148	18838386
STAGA	ATXN7 ATXN7L3 ENY2 KAT2A SAP130 SGF29 SUPT3H SUPT7L TADA1 TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22	O15265 O75486 O75528 O75529 O94864 Q12962 Q14CW9 Q16514 Q16594 Q92830 Q96BN2 Q96ES7 Q9H0E3 Q9NPA8 Q9UPT9 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC521	18206973 18206972 11564863 15932940
STAGA	KAT2A SAP130 SUPT3H SUPT7L TADA1 TADA2A TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22	O75478 O75486 O75528 O75529 O94864 Q12962 Q16514 Q16594 Q92830 Q96BN2 Q9H0E3 Q9UPT9 Q9Y4A5 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0:0:0:0	SPIKE

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody

HPA001399 CAB004307 HPA023884 CAB080432