Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class (8)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificCytotrophoblasts

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence157

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition (144)

144 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
STAGA complex	ATXN7 KAT2A SF3B3 SUPT3H SUPT7L TADA1 TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP	O15265 O75486 O75528 O75529 O94864 Q12962 Q15393 Q16514 Q16594 Q92830 Q96BN2 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC2376CORUM:476	15115762
STAGA complex	KAT2A SF3B3 SUPT3H SUPT7L TADA1 TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP	O75486 O75528 O75529 O94864 Q12962 Q15393 Q16514 Q16594 Q92830 Q96BN2 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC3411CORUM:475	11564863
STAGA complex	KAT2A SAP130 SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP	O75486 O75528 O75529 O94864 Q12962 Q16514 Q16594 Q86TJ2 Q92830 Q96BN2 Q9H0E3 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC142	11564863
STAGA complexSPT3-linked	ATXN7 ATXN7L3 ENY2 KAT2A SAP130 SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22	O15265 O75486 O75528 O75529 O94864 Q12962 Q14CW9 Q16514 Q16594 Q86TJ2 Q8NEM7 Q92830 Q96BN2 Q96ES7 Q9H0E3 Q9NPA8 Q9UPT9 Q9Y4A5 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	CORUM	CORUM:6664	18838386
TFTC	ATXN7 ATXN7L3 ENY2 KAT2A SAP130 SUPT3H TADA3 TAF10 TAF12 TAF2 TAF4 TAF5 TAF5L TAF6 TAF7 TAF9 TRRAP USP22	O00268 O15265 O75486 O75528 O75529 P49848 Q12962 Q14CW9 Q15542 Q15545 Q16514 Q16594 Q6P1X5 Q92830 Q9H0E3 Q9NPA8 Q9UPT9 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC387	15115762 10373431 11406595 9603525 18206972 18206973 12601814
TFTC complex (TATA-binding protein-free TAF-II-containing complex)	ATXN7 KAT2A SF3B3 SUPT3H TADA3 TAF10 TAF12 TAF13 TAF2 TAF4 TAF5 TAF5L TAF6 TAF6L TAF7 TAF9 TRRAP	O00268 O15265 O75486 O75528 O75529 P49848 Q12962 Q15393 Q15542 Q15543 Q15545 Q16514 Q16594 Q6P1X5 Q92830 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC1803CORUM:470	10591645
TFTC complex (TATA-binding protein-free TAF-II-containing complex)	ATXN7 KAT2A SF3B3 SUPT3H TADA3 TAF10 TAF12 TAF2 TAF4 TAF5 TAF5L TAF6 TAF6L TAF7 TAF9 TAF9B TRRAP	O00268 O15265 O75486 O75528 O75529 P49848 Q12962 Q15393 Q15542 Q15545 Q16514 Q16594 Q6P1X5 Q92830 Q9HBM6 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCORUM	CORUM:513Compleat:HC2834	15899866
TFTC complex (TATA-binding protein-free TAF-II-containing complex)	ATXN7 KAT2A SF3B3 SUPT3H TADA3 TAF10 TAF12 TAF2 TAF4 TAF5 TAF5L TAF6 TAF6L TAF7 TAF9 TRRAP	O00268 O15265 O75486 O75528 O75529 P49848 Q12962 Q15393 Q15542 Q15545 Q16514 Q16594 Q6P1X5 Q92830 Q9Y4A5 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC343CORUM:445	12601814 15115762 9603525 10373431
TFTC histone acetylation complex	ATXN7 ATXN7L3 ENY2 KAT2A SUPT3H TADA3 TAF10 TAF12 TAF2 TAF4 TAF5 TAF5L TAF6 TAF7 TAF9 TRRAP USP22	O00268 O15265 O75486 O75528 O75529 P49848 Q12962 Q14CW9 Q15542 Q15545 Q16514 Q16594 Q6P1X5 Q92830 Q9NPA8 Q9UPT9 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:1h3ointact:EBI-12600215	15115762 33004486 10373431 11406595 9603525 14755292 18206972 10591645
USP22-SAGA complex	ATXN7L3 KAT2A TADA2B TADA3 TAF10 TAF9B TRRAP USP22	O75528 Q12962 Q14CW9 Q86TJ2 Q92830 Q9HBM6 Q9UPT9 Q9Y4A5	0:0:0:0:0:0:0:0	CORUM	CORUM:6641	18206973

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains10

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families (2)

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance6

Disease Involvement (4)

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases (6)

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody (4)

HPA001399 CAB004307 HPA023884 CAB080432

Supporting Publications1

PMID	Title	Abstract
38892056	ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.	Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.