Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein symbol ADA	UniProt ID P00813	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificCytotrophoblasts

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition

144 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex	ADAM8 VCAM1	P19320 P78325	1:1	Compleat	Compleat:HC2321	15220135
transcription factor TFTC complex	KAT2A SUPT3H TADA3 TAF10 TAF12 TAF2 TAF4 TAF5 TAF5L TAF6 TAF7 TAF9 TAF9B TRRAP	O00268 O75486 O75528 O75529 P49848 Q12962 Q15542 Q15545 Q16514 Q16594 Q6P1X5 Q92830 Q9HBM6 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC3144	9603525 15899866 10373431
	CIBAR1 KAT14 KAT2A KAT2B MBIP SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TAF9B YEATS2 ZZZ3	A1XBS5 O75478 O75486 O75528 O75529 O94864 Q12962 Q16514 Q16594 Q86TJ2 Q8IYH5 Q8NEM7 Q92830 Q92831 Q96BN2 Q96ES7 Q9H8E8 Q9HBM6 Q9NS73 Q9ULM3 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	ATXN7 ATXN7L3 ENY2 KAT2A RPAP1 SGF29 SUPT3H TADA1 TADA3 TAF10 TAF5L TAF9 TRRAP USP22 USP27X	A6NNY8 O15265 O75486 O75528 O75529 Q12962 Q14CW9 Q16594 Q92830 Q96BN2 Q96ES7 Q9BWH6 Q9NPA8 Q9UPT9 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9632
	ADARB1 COPS4 IPO5 LDOC1 PEG10 RTL8A RTL8B RTL8C USP9X	A6ZKI3 O00410 O95751 P78563 Q17RB0 Q86TG7 Q93008 Q9BT78 Q9BWD3	0:0:0:0:0:0:0:0:0	hu.MAP2
	ATXN7 F2Z2U4 SF3B3 SF3B5 SUPT20H SUPT3H SUPT7L TADA1 TAF10 TAF12 TAF5L TAF6L TAF9B	F2Z2U4 O15265 O75486 O75529 O94864 Q12962 Q15393 Q16514 Q8NEM7 Q96BN2 Q9BWJ5 Q9HBM6 Q9Y6J9	1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:7kts
	DAZAP1 NONO POLR2A POLR2B POLR2C POLR2D POLR2H POLR2K PSPC1 SFPQ SUMO2 SUPT5H TADA2A TCERG1 U2AF2	O00267 O14776 O15514 O75478 P19387 P23246 P24928 P26368 P30876 P52434 P53803 P61956 Q15233 Q8WXF1 Q96EP5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9192
	SUPT3H TADA1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF2 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBP	O00268 O75486 P20226 P21675 P49848 Q12962 Q15542 Q15543 Q15544 Q15545 Q16514 Q16594 Q6P1X5 Q7Z7C8 Q96BN2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7391
	RFX1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF2 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBP	O00268 O75528 P20226 P21675 P22670 P49848 Q12962 Q15542 Q15543 Q15544 Q15545 Q16514 Q16594 Q6P1X5 Q7Z7C8	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5038
	ADARB1 COPS4 IPO5 LDOC1 PEG10 RTL8A RTL8B RTL8C USP9X	O00410 O15255 O95751 P78563 Q17RB0 Q86TG7 Q93008 Q9BT78 Q9BWD3	0:0:0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody

HPA001399 CAB004307 HPA023884 CAB080432