Protein detail
ADA
Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
Entry name ADA | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
Protein Class (8)
Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ADA1
Gene Description
Adenosine deaminase
Chromosome
20
Position
44584896-44652252
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificCytotrophoblasts
Function & Pathway7
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (8)
Molecular Function (5)
Biological Process (3)
KEGG (4)
Reactome (6)
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence157
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA | P00813 | AA1R | P30542 | Yes | Yes | No | HPRDSPIKE_LCSIGNOR | HPRD:12150791HPRD:9247966SIGNOR:18680557SPIKE_LC:16713569 |
Protein Complex Composition (144)
144 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains10
Sequences
Length
363
Mass
40,764
Sequence
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
3D Structural Models
Turn
92..94; 172..176
Helix
18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362
Beta Strand
11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Region
126..143; Required for binding to DDP4
Protein Families (2)
- Metallo-dependent hydrolases superfamily
- Adenosine and AMP deaminases family
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Clinical Relevance6
Disease Involvement (4)
Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID
Related Diseases (6)
Biomarker
Approved; Preregistration; Phase 3
Drug Targets
FDA approved drug targets
Drugs (24)
LEVODOPAMETHYLMERCAPTOPURINE RIBOSIDEANTIMALARIAL AGENTMETHOTREXATEDIFFERENTIATION INDUCERNULLRECOMBINANT PROTHYMOSIN ALPHAASPIRINFLUDARABINECLADRIBINEH2O2PENTOSTATINCOBALTCORDYCEPINELAPEGADEMASE-LVLRCOFORMYCINTILARGININEDIDEOXYADENOSINERECOMBINANT INTERLEUKINSELENIUMGARLICAMITRIPTYLINE HYDROCHLORIDEHYDROCORTISONE BUTYRATEELAPEGADEMASE
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38892056 | ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins. | Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface. |