Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class (8)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificCytotrophoblasts

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence157

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition (144)

144 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
KAT14 KAT2A KAT2B TADA2A TADA3 YEATS2 ZZZ3	O75478 O75528 Q8IYH5 Q92830 Q92831 Q9H8E8 Q9ULM3	0:0:0:0:0:0:0	hu.MAP
SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TAF9B	O75486 O75528 O75529 O94864 Q12962 Q16514 Q16594 Q86TJ2 Q8NEM7 Q96BN2 Q9HBM6 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF5L TAF6L TERF2 TERF2IP	O75486 O75528 O75529 O94864 Q15554 Q86TJ2 Q8NEM7 Q96BN2 Q96ES7 Q9NYB0 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
SUPT20H SUPT3H SUPT7L TADA1 TADA2B TADA3 TAF12 TAF5L TAF6L	O75486 O75528 O75529 O94864 Q16514 Q86TJ2 Q8NEM7 Q96BN2 Q9Y6J9	0:0:0:0:0:0:0:0:0	hu.MAP2
KAT2A KAT2B SGF29 SUPT20H SUPT3H SUPT7L TADA3 TAF5L TAF6L	O75486 O75528 O75529 O94864 Q8NEM7 Q92830 Q92831 Q96ES7 Q9Y6J9	0:0:0:0:0:0:0:0:0	hu.MAP
SUPT20H SUPT3H SUPT7L TADA1 TADA2B TAF10 TAF12 TAF5L TAF6L TAF9 TAF9B	O75486 O75529 O94864 Q12962 Q16514 Q16594 Q86TJ2 Q8NEM7 Q96BN2 Q9HBM6 Q9Y6J9	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
LSM11 TADA3 TAF5L TOP3A	O75528 O75529 P83369 Q13472	0:0:0:0	Havugimana2012	Havugimana2012:C_241
NUP205 SGF29 TADA3 TAF5L	O75528 O75529 Q92621 Q96ES7	0:0:0:0	Havugimana2012	Havugimana2012:C_199
BRCA1 EP300 GEM ING5 KAT2A RAD51 SUPT7L TADA3 TAF10 TAF3 TAF9 TP53 TRRAP	O75528 O94864 P04637 P38398 P55040 Q06609 Q09472 Q12962 Q16594 Q5VWG9 Q8WYH8 Q92830 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6330
CTRL GEM KAT2A KAT5 OTOP2 SUPT7L TADA3 TAF10 TAF9 TP53 TRRAP	O75528 O94864 P04637 P40313 P55040 Q12962 Q16594 Q7RTS6 Q92830 Q92993 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4330

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains10

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families (2)

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance6

Disease Involvement (4)

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases (6)

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody (4)

HPA001399 CAB004307 HPA023884 CAB080432

Supporting Publications1

PMID	Title	Abstract
38892056	ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.	Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.