Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class (8)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificCytotrophoblasts

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence157

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition (144)

144 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ADAM22-LGI1 complex	ADAM22 LGI1	O95970 Q9P0K1	6:6	CORUMPDB	PDB:5y2zPDB:5y31PDB:8y6bPDB:8hpyPDB:8hq2CORUM:7395PDB:9kzcPDB:9kztPDB:8hq1	29670100
ADAR1-CDK2 complex	ADAR CDK2	P24941 P55265	1:1	Compleat	Compleat:HC691	17224799
ATAC complexGCN5-linked	DR1 KAT14 KAT2A MBIP SGF29 TADA2A TADA3 WDR5 YEATS2 ZZZ3	O75478 O75528 P61964 Q01658 Q8IYH5 Q92830 Q96ES7 Q9H8E8 Q9NS73 Q9ULM3	1:1:1:1:1:1:1:1:1:1	CORUMComplexPortal	CORUM:6657intact:EBI-13636711	19936620 22055187 26468280 19103755 14755292 18838386 20562830
DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex	ADAR DHX9 HDLBP PRKDC XRCC5 XRCC6	P12956 P13010 P55265 P78527 Q00341 Q08211	1:1:1:1:1:1	CompleatCORUM	Compleat:HC1153CORUM:3102	15723802
GCN5-TRRAP histone acetyltransferase complex	BRCA1 KAT2A MSH2 MSH6 SUPT3H TADA3 TAF10 TAF5L TAF9 TRRAP	O75486 O75528 O75529 P38398 P43246 P52701 Q12962 Q16594 Q92830 Q9Y4A5	1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC2134CORUM:438	16260778
HT_SC_Cluster141	IPO4 TADA2B	Q86TJ2 Q8TEX9	1:1	Compleat	Compleat:HC1467
HT_SC_Cluster159	FTSJ1 THADA WDR6	Q6YHU6 Q9NNW5 Q9UET6	1:1:1	Compleat	Compleat:HC1261
HT_SC_Cluster334	ADA HERC2 MAPDA	O95714 P00813 Q6DHV7	1:1:1	Compleat	Compleat:HC2516
LKB1-STRAD-MO25 complex	CAB39 STK11 STRADA	Q15831 Q7RTN6 Q9Y376	2:2:2	CORUMComplexPortalPDB	PDB:2wtkintact:EBI-9026830PDB:8vsuCORUM:6053	14755292 19892943
LKB1-STRAD-MO25 serine/threonine protein kinase complexCAB39L-STRADA variant	CAB39L STK11 STRADA	Q15831 Q7RTN6 Q9H9S4	1:1:1	hu.MAPComplexPortal	intact:EBI-9016546	14755292 19892943

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains10

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families (2)

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance6

Disease Involvement (4)

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases (6)

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody (4)

HPA001399 CAB004307 HPA023884 CAB080432

Supporting Publications1

PMID	Title	Abstract
38892056	ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.	Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.