Protein detail
TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Entry name TGFB1 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 20 | Transmembrane count | Protein classification Human disease related genesPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Protein Class (2)
Human disease related genesPredicted secreted proteins
Protein Function (4)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CEDDPD1TGFBTGFbeta
Gene Description
Transforming growth factor beta 1
Chromosome
19
Position
41301587-41353922
Supporting publications (n)
20
EVMP confidence score
0.60
Fluorescence & Localization6
Tissue SpecificbrainCell SpecificB-cellsSingle-Nuclei Brain Specificmedium spiny neuronBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (4)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Cellular Component (14)
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005796 Golgi lumen
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0009986 cell surface
- GO:0030424 axon
- GO:0031012 extracellular matrix
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Molecular Function (11)
- GO:0005114 type II transforming growth factor beta receptor binding
- GO:0005125 cytokine activity
- GO:0005515 protein binding
- GO:0008083 growth factor activity
- GO:0019899 enzyme binding
- GO:0034713 type I transforming growth factor beta receptor binding
- GO:0034714 type III transforming growth factor beta receptor binding
- GO:0035800 deubiquitinase activator activity
- GO:0042802 identical protein binding
- GO:0043539 protein serine/threonine kinase activator activity
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Biological Process (3)
KEGG (36)
- hsa04010 MAPK signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04110 Cell cycle
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04218 Cellular senescence
- KEGG:hsa04350 TGF-beta signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04518 Integrin signaling
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Reactome (36)
- R-hsa-9843745 adipogenesis
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-2173788 downregulation of tgf beta receptor signaling
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence68
Ligand-Receptor Signaling (49)
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | CellPhoneDB | Yes | No | Yes | No | No |
| ligand | ligand | GO_Intercell | Yes | No | Yes | No | No |
| ligand | ligand | ICELLNET | Yes | No | Yes | No | No |
| ligand | ligand | CellChatDB | Yes | No | Yes | No | No |
| ligand | ligand | CellTalkDB | Yes | No | Yes | No | No |
| ligand | ligand | Ramilowski2015 | Yes | No | Yes | No | No |
| ligand | ligand | Kirouac2010 | Yes | No | Yes | No | No |
| ligand | ligand | Guide2Pharma | Yes | No | Yes | No | No |
| growth_factor | ligand | DGIdb | Yes | No | Yes | No | No |
| ligand | ligand | DGIdb | Yes | No | Yes | No | No |
Regulatory Interaction Network (13)
13 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TDGF1 | P13385 | TGFB1 | P01137 | Yes | No | Yes | WangSIGNOR | SIGNOR:17030617 |
| MMP9 | P14780 | TGFB1 | P01137 | Yes | Yes | No | WangLit-BM-17SIGNORACSN | Lit-BM-17:25241761SIGNOR:10652271ACSN:21900405Lit-BM-17:10652271 |
| LTBP1 | Q14766 | TGFB1 | P01137 | Yes | Yes | Yes | SIGNORHINTIntActDIPWangCellChatDB-cofactors | SIGNOR:8432736HINT:12429738HINT:10930463DIP:21677751IntAct:21677751HINT:21677751 |
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Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TGF-beta-1 complex | TGFB1 | P01137 | 2 | ComplexPortalPDB | PDB:6p7jPDB:8udzPDB:4kv5PDB:1klcPDB:5vqpPDB:1kldPDB:1klaintact:EBI-12501958 | 2397970729109152252091761206575614755292867961313338882020773822943793 |
| CDC45MCM10MCM2MCM3MCM4MCM6MCM7ORC2ORC4SMAD2TGFB1 | O43929O75419P01137P25205P33991P33993P49736Q13416Q14566Q15796Q7L590 | 1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7295 | ||
| TGFB1TGFB3 | P01137P10600 | 0:0 | hu.MAP2 | |||
| BMP3TGFB1WFIKKN1WFIKKN2 | P01137P12645Q8TEU8Q96NZ8 | 1:1:1:1 | CompleatCFinder | Compleat:HC5891 | ||
| NRROSTGFB1 | P01137Q86YC3 | 2:1 | PDB | PDB:7y1r |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry [LTQ-FT Ultra] | 0 |
Sequence, Structure & Domains12
Sequences
Length
390
Mass
44,325
Sequence
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
3D Structural Models
Turn
120..122; 123..126; 282..284; 337..341; 344..346
Helix
38..56; 75..85; 116..119; 137..143; 147..149; 201..207; 265..268; 285..288; 302..306
Beta Strand
70..72; 106..112; 131..136; 144..146; 150..157; 166..170; 175..177; 179..181; 184..187; 196..199; 214..221; 224..230; 232..235; 242..244; 245..248; 251..254; 257..262; 294..296; 299..301; 311..313; 315..318; 321..323; 330..332; 347..349; 350..353; 355..370; 373..390
3D Structure
Electron microscopy (7); NMR spectroscopy (3); X-ray crystallography (7)
Domain & Motif Annotations
Motif
244..246; Cell attachment site
Domain (CC)
[Latency-associated peptide]: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104..; DOMAIN: [Latency-associated peptide]: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8) (PubMed:28117447). The motif locates to a long loop in the arm domain called the bowtie tail (PubMed:28117447). Integrin-binding stabilizes an alternative conformation of the bowtie tail (PubMed:28117447). Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1 (PubMed:28117447).
Region
30..74; Straightjacket domain; 75..271; Arm domain; 226..252; Bowtie tail
Protein Families
TGF-beta family
Sequence Similarities
Belongs to the TGF-beta family.
Clinical Relevance5
Related Diseases (12)
Biomarker
Phase 2/3; Phase 1/2; Approved; Discontinued in Phase 2; Phase 2; Investigative; Phase 1; Phase 3; IND submitted
Drug Targets (2)
Clinical trial targetSuccessful target
Drugs (59)
SANDOSTATINTOREMIFENEVITAMIN EINTERFERON ALFA-2BTAMOXIFENADRIAMYCINNICOTINE POLACRILEXEMODINASPIRINSILYMARINBINTRAFUSP ALFAESTRADIOL VALERATEINOSITOLFRESOLIMUMABPROTEASOME INHIBITORPIOGLITAZONE HYDROCHLORIDEIDOXURIDINERETINOIC ACID AGENTTESTOSTERONERITUXIMABETOPOSIDENULLGALLIUM NITRATEVACTOSERTIBAMIFOSTINE ANHYDROUSDOXORUBICIN HYDROCHLORIDEPIRFENIDONEGENISTEINATENOLOLHYDROCORTISONE BUTYRATEH2O2STREPTOZOCINIRINOTECAN HYDROCHLORIDEFENRETINIDEGOSSYPOLCLADRIBINETRETINOINGLATIRAMERNISEVOKITUGANTIOXIDANTISOTRETINOINANTISENSE OLIGONUCLEOTIDESKEYHOLE LIMPET HEMOCYANINDISITERTIDETRIAMCINOLONEGALUNISERTIBMELATONINSOTATERCEPTRAMIPRILMETELIMUMABLY-2382770TCDDVERAPAMILTHERAPEUTIC ANDROGENBROXURIDINEBOVINE CARTILAGELUSPATERCEPT-AAMTALPHA-TOCOPHEROLHEPARAN SULFATE
Supporting Publications19
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32284825 | Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. | No abstract available |
| 32341357 | CD41-deficient exosomes from non-traumatic femoral head necrosis tissues impair osteogenic differentiation and migration of mesenchymal stem cells. | Taken together, our study results revealed that in the progress of ONFH, exosomes from the pathological bone brought about the failure of MSCs repairing the necrotic bone for lack of some critical proteins, like integrin CD41, and prompted the progression of experimentally induced ONFH-like status in the rat. |
| 32489530 | Quantitative proteomic analysis of trypsin-treated extracellular vesicles to identify the real-vesicular proteins. | No abstract available |
| 33204424 | Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
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