Protein detail
CD4
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Protein symbol CD4 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 1 | Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Protein Class
CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
397..418; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
CD4 molecule
Chromosome
12
Position
6786858-6820799
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificRetinal amacrine cellsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
- GO:0001618 virus receptor activity
- GO:0004888 transmembrane signaling receptor activity
- GO:0005201 extracellular matrix structural constituent
- GO:0005515 protein binding
- GO:0008270 zinc ion binding
- GO:0008289 lipid binding
- GO:0015026 coreceptor activity
- GO:0019899 enzyme binding
- GO:0019901 protein kinase binding
- GO:0023026 MHC class II protein complex binding
- GO:0038023 signaling receptor activity
- GO:0042011 interleukin-16 binding
- GO:0042012 interleukin-16 receptor activity
- GO:0042289 MHC class II protein binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:1990782 protein tyrosine kinase binding
Biological Process
KEGG
- hsa03250 Viral life cycle - HIV-1
- KEGG:hsa03260 Virion - Human immunodeficiency virus
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04612 Antigen processing and presentation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
- KEGG:hsa05340 Primary immunodeficiency
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1462054 alpha defensins
- R-hsa-6803157 antimicrobial peptides
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-389948 co inhibition by pd 1
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1461973 defensins
- R-hsa-202424 downstream tcr signaling
- R-hsa-162594 early phase of hiv life cycle
- R-hsa-202433 generation of second messenger molecules
- R-hsa-162906 hiv infection
- R-hsa-162587 hiv life cycle
- R-hsa-162909 host interactions of hiv factors
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-199991 membrane trafficking
- R-hsa-167590 nef mediated cd4 down regulation
- R-hsa-164938 nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- R-hsa-449836 other interleukin signaling
- R-hsa-202427 phosphorylation of cd3 and tcr zeta chains
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-449147 signaling by interleukins
- R-hsa-202403 tcr signaling
- R-hsa-164952 the role of nef in hiv 1 replication and disease pathogenesis
- R-hsa-5653656 vesicle mediated transport
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD4 | PRKCA | P17252 | S | 440 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| CD4 | PRKCA | P17252 | S | 433 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| CD4 | PRKCQ | Q04759 | S | 433 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:19050241 |
Ligand-Receptor Signaling
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
Regulatory Interaction Network
64 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:CHEBI:166824_CHEBI:53000_P01909_P13762 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P06340_P28068 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P06340_P79483 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P01906_Q30154 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P20036_P28068 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P13765_P20036 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P01903_P01911 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P01903_P01912 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P04440_P20036 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 | |
| COMPLEX:CHEBI:166824_CHEBI:53000_P01912_P28067 | CD4 | P01730 | Yes | Yes | No | SIGNOR | SIGNOR:31001252 |
Protein Complex Composition
27 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CD44-ERK1-ERK2-RHAMM complex | CD44HMMRMAPK1MAPK3 | O75330P16070P27361P28482 | 0:0:0:0 | CORUM | CORUM:7504 | 17392272 |
| Cd74-Cd44 receptor complex | CD44CD74 | P04233P16070 | 1:1 | CellinkerCompleatCellChatDB | Compleat:HC62 | 18056708 |
| Interleukin-16 receptor-ligand complex | CD4IL16 | P01730Q14005 | 1:1 | ComplexPortal | intact:EBI-55041356 | 27231345942278096996301475529210809960 |
| ABCD4DEPDC1FAM234BFRMD5LAPTM4ARUSF1TMEM214 | A2RU67O14678Q15012Q5TB30Q6NUQ4Q7Z6J6Q96GQ5 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| ABCD4DEPDC1FAM234BFRMD5LAPTM4ARUSF1 | A2RU67O14678Q15012Q5TB30Q7Z6J6Q96GQ5 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ABCD4FAM234BFRMD5LAPTM4A | A2RU67O14678Q15012Q7Z6J6 | 0:0:0:0 | hu.MAP2 | |||
| ABCD4FAM234BFRMD5 | A2RU67O14678Q7Z6J6 | 0:0:0 | hu.MAP2 | |||
| ABCD4 | O14678 | 2 | PDB | PDB:6jbj | ||
| BLTP1BTRCGLI3PDCD4SLC16A4 | O15374P10071Q2LD37Q53EL6Q9Y297 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4003 | ||
| FAM114A2HSPA12APDCD4RAB5IFTMEM51 | O43301Q53EL6Q9BUV8Q9NRY5Q9NW97 | 0:0:0:0:0 | hu.MAP |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 30646616 |
Sequence, Structure & Domains
Sequences
Length
458
Mass
51,111
Sequence
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
3D Structural Models
Turn
75..79
Helix
84..89; 101..103; 176..178; 398..421; 432..438
Beta Strand
27..32; 37..39; 44..47; 51..55; 56..58; 60..63; 68..71; 94..96; 105..111; 114..128; 131..134; 135..137; 139..144; 152..156; 158..160; 162..172; 180..188; 191..199; 200..202; 426..428; 440..442
3D Structure
Electron microscopy (29); NMR spectroscopy (3); X-ray crystallography (50)
Domain & Motif Annotations
Domain (CC)
The Ig-like V-type domain mediates the interaction with MHCII.
Domain (FT)
26..125; Ig-like V-type; 126..203; Ig-like C2-type 1; 204..317; Ig-like C2-type 2; 318..374; Ig-like C2-type 3
Region
427..455; HIV-1 Vpu-susceptibility domain
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 3; Phase 2; Approved; Phase 1; Discontinued in Phase 2; Investigative
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000182866
Interaction Count
1
Interaction Dataset
intact_biogrid