Protein detail
CD8A
T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
Entry name CD8A | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
Protein Class
CD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- CD markers
- Predicted intracellular proteins
Transmembrane
183..203; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD8
Gene Description
CD8a molecule
Chromosome
2
Position
86784610-86808396
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| ligand | ligand | OmniPath | Yes | No | Yes | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | Yes | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:CHEBI:166824_P01889_P61769 | CD8A | P01732 | Yes | Yes | No | SIGNOR | SIGNOR:21954283 | |
| COMPLEX:CHEBI:166824_P17693_P61769 | CD8A | P01732 | Yes | Yes | No | SIGNOR | SIGNOR:21954283 | |
| COMPLEX:CHEBI:166824_P30511_P61769 | CD8A | P01732 | Yes | Yes | No | SIGNOR | SIGNOR:21954283 | |
| COMPLEX:CHEBI:166824_P13747_P61769 | CD8A | P01732 | Yes | Yes | No | SIGNOR | SIGNOR:21954283 | |
| COMPLEX:CHEBI:166824_P04439_P61769 | CD8A | P01732 | Yes | Yes | No | SIGNOR | SIGNOR:21954283 | |
| COMPLEX:CHEBI:166824_P10321_P61769 | CD8A | P01732 | Yes | Yes | No | SIGNOR | SIGNOR:21954283 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CD8A-LCK complex | CD8ALCK | P01732P06239 | 1:1 | CompleatCORUMPDB | Compleat:HC1965CORUM:1067PDB:1q69 | 11034334 |
| CD8alpha-alpha complex | CD8A | P01732 | 2 | ComplexPortalPDB | intact:EBI-26975977PDB:1cd8PDB:2hp4PDB:7uvf | 220811441475529217243170 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
235
Mass
25,729
Sequence
MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=membrane, mCD8alpha; IsoId=P01732-1; Sequence=Displayed; Name=2; Synonyms=secreted, sCD8alpha; IsoId=P01732-2; Sequence=VSP_012653; Name=3; IsoId=P01732-3; Sequence=VSP_054438
Alternative Sequence
1; M -> MRNQAPGRPKGATFPPRRPTGSRAPPLAPELRAKQRPGERVM (in isoform 3); 172..209; VHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHR -> G (in isoform 2)
3D Structural Models
Turn
86..88
Helix
107..109
Beta Strand
24..27; 39..45; 54..63; 68..73; 74..76; 89..94; 97..104; 111..119; 122..125; 129..131
3D Structure
NMR spectroscopy (1); X-ray crystallography (7)
Domain & Motif Annotations
Domain (FT)
22..135; Ig-like V-type