Protein detail
HLAB
HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)
Entry name HLAB | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (9)
- Cancer-related genes:Mutational cancer driver genes
- Disease related genes
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- Human disease related genes:Musculoskeletal diseases:Other musculoskeletal diseases
Transmembrane
310..333; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
AS
Gene Description
Major histocompatibility complex, class I, B
Chromosome
6
Position
31353872-31367067
Supporting publications (n)
3
EVMP confidence score
0.25
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificAdipocytes
Function & Pathway7
Protein Function (9)
- Cancer-related genes:Mutational cancer driver genes
- Disease related genes
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- Human disease related genes:Musculoskeletal diseases:Other musculoskeletal diseases
Cellular Component (16)
- GO:0000139 Golgi membrane
- GO:0005615 extracellular space
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0012507 ER to Golgi transport vesicle membrane
- GO:0016020 membrane
- GO:0030667 secretory granule membrane
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Molecular Function (5)
Biological Process (3)
KEGG (19)
- hsa04144 Endocytosis
- KEGG:hsa04145 Phagosome
- KEGG:hsa04218 Cellular senescence
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04612 Antigen processing and presentation
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04940 Type I diabetes mellitus
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
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Reactome (19)
- R-hsa-1280218 adaptive immune system
- R-hsa-983170 antigen presentation folding assembly and peptide loading of class i mhc
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-2172127 dap12 interactions
- R-hsa-1236977 endosomal vacuolar pathway
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence53
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HLA-B | SRC | P12931 | Y | 344 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling (48)
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | HLAB | P01889 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointProtMapperHPRDPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:6304688HPRD:6304688ProtMapper:6304688 |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37459063 |
Sequence, Structure & Domains12
Sequences
Length
362
Mass
40,460
Sequence
MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
3D Structural Models
Turn
67..69; 199..204; 275..277
Helix
74..76; 77..79; 81..108; 162..173; 176..185; 187..198; 249..251; 278..280
Beta Strand
27..36; 41..43; 45..52; 55..61; 64..66; 70..73; 113..115; 118..127; 129..131; 133..142; 145..150; 157..161; 210..219; 222..235; 238..243; 246..248; 252..254; 261..263; 265..274; 281..286; 290..292; 294..296
3D Structure
X-ray crystallography (233)
Domain & Motif Annotations
Compositional Bias
346..362; Polar residues
Motif
101..107; Bw6 motif
Domain (CC)
The alpha-1 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Residues 101-107 determine Bw4/Bw6 motifs, which serologically distinguish HLA-B alleles. Each HLA-B allele possesses either the Bw4 or Bw6 motif. Only HLA-B alleles bearing the Bw4 epitope are recognized by NK cell inhibitory receptor KIR3DL1 (PubMed:22020283, PubMed:25480565).; DOMAIN: The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:25808313). Mediates the interaction with TAP1-TAP2 complex (By similarity).; DOMAIN: The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor.; DOMAIN: The VL9 peptide/epitope (VMAPRT[V/L][L/V/I/F]L) derived from the signal sequence is loaded onto HLA-E and enables HLA-E expression at the plasma membrane. Distinct VL9 peptides presented by HLA-E variably affect its recognition by KLRD1-KLRC1 or KLRD1-KLRC2 receptors on NK cells. Most HLA-B allotypes contain VL9 peptides with low affinity for HLA-E. The VL9 peptide derived from HLA-B*07, B*08, B*14, B*38, B*39, B*42 and B*48 allotypes, displays high affinity for HLA-E yet fails to drive NK cell activation. It outcompetes other VL9 peptides derived from HLA-A and HLA-C for binding to HLA-E, lowering the threshold of NK cell activation.
Domain (FT)
209..295; Ig-like C1-type
Region
3..11; VL9 epitope; 25..114; Alpha-1; 115..206; Alpha-2; 207..298; Alpha-3; 299..309; Connecting peptide; 337..362; Disordered
Clinical Relevance8
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 3
Drugs (39)
CARBIMAZOLENULLCLINDAMYCININTERFERON BETA-1APENICILLIN VCLAVULANIC ACIDLAMIVUDINEPEGINTERFERON ALFA-2AFLOXACILLINABACAVIRTICLOPIDINEMINOCYCLINECARBAMAZEPINECLOZAPINEINFLIXIMAB-DYYBRIBAVIRINPHENYTOIN SODIUMMEASLES VACCINEFOSPHENYTOINLAPATINIBPEGINTERFERON ALFA-2BAMOXICILLIN ANHYDROUSMETHIMAZOLESULFASALAZINEPAZOPANIBSTAVUDINETRICHLOROETHYLENERECOMBINANT INTERFERONVELIMOGENE ALIPLASMIDSULFAMETHOXAZOLE / TRIMETHOPRIMDAPSONEOXCARBAZEPINEISONIAZIDBACILLUS CALMETTE-GUERIN ANTIGENPENICILLIN G POTASSIUMTHALIDOMIDEMETHAZOLAMIDEETANERCEPT-SZZSACETAZOLAMIDE
Antibody
Interaction Protein (2)
ENSG00000166710ENSG00000204525
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |