Protein detail
DRA
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
Protein symbol DRA | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
Protein Class
Plasma proteinsPredicted membrane proteins
Transmembrane
217..239; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
HLA-DRA1
Gene Description
Major histocompatibility complex, class II, DR alpha
Chromosome
6
Position
32439878-32445046
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Cellular Component
- GO:0000139 Golgi membrane
- GO:0001772 immunological synapse
- GO:0005764 lysosome
- GO:0005765 lysosomal membrane
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0012507 ER to Golgi transport vesicle membrane
- GO:0030658 transport vesicle membrane
- GO:0030666 endocytic vesicle membrane
- GO:0030669 clathrin-coated endocytic vesicle membrane
- GO:0031901 early endosome membrane
- GO:0031902 late endosome membrane
- GO:0032588 trans-Golgi network membrane
- GO:0042613 MHC class II protein complex
- GO:0070062 extracellular exosome
- GO:0098553 lumenal side of endoplasmic reticulum membrane
- GO:0120281 autolysosome membrane
Molecular Function
Biological Process
KEGG
- hsa04145 Phagosome
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04612 Antigen processing and presentation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04672 Intestinal immune network for IgA production
- KEGG:hsa04940 Type I diabetes mellitus
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05164 Influenza A
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05310 Asthma
- KEGG:hsa05320 Autoimmune thyroid disease
- KEGG:hsa05321 Inflammatory bowel disease
- KEGG:hsa05322 Systemic lupus erythematosus
- KEGG:hsa05323 Rheumatoid arthritis
- KEGG:hsa05330 Allograft rejection
- KEGG:hsa05332 Graft-versus-host disease
- KEGG:hsa05416 Viral myocarditis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-389948 co inhibition by pd 1
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-202424 downstream tcr signaling
- R-hsa-202433 generation of second messenger molecules
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-2132295 mhc class ii antigen presentation
- R-hsa-202427 phosphorylation of cd3 and tcr zeta chains
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-202403 tcr signaling
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HLA-DRA | MARCHF1 | Q8TCQ1 | K | 244 | polyubiquitination | SIGNOR | SIGNOR:19117940 |
| HLA-DRA | MARCHF8 | Q5T0T0 | K | 244 | polyubiquitination | SIGNOR | SIGNOR:19117940 |
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| mhc | cell_surface_ligand | Almen2009 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MARH8 | Q5T0T0 | DRA | P01903 | Yes | No | Yes | SIGNOR | SIGNOR:19117940 |
| MARH1 | Q8TCQ1 | DRA | P01903 | Yes | No | Yes | SIGNORBioGRID | BioGRID:18389477SIGNOR:19117940BioGRID:23264739 |
| COMPLEX:P03205_P03212_P03231 | DRA | P01903 | Yes | Yes | No | SIGNOR | SIGNOR:11864610 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 37922300 |
Sequence, Structure & Domains
Sequences
Length
254
Mass
28,621
Sequence
MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL
3D Structural Models
Turn
41..43; 61..64; 102..104
Helix
71..74; 82..101
Beta Strand
29..40; 44..51; 54..60; 65..70; 113..120; 124..126; 128..140; 143..148; 151..153; 155..159; 166..168; 170..178; 186..191; 195..197; 199..203
3D Structure
Electron microscopy (2); X-ray crystallography (137)
Domain & Motif Annotations
Domain (CC)
The alpha-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the beta-1 domain of HLA-DRB. Forms hydrogen bonds with the peptide main chain via conserved amino acids (PubMed:17583734, PubMed:29884618, PubMed:8145819, PubMed:9354468, PubMed:9782128). The peptide-bound alpha-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domain of TCR (PubMed:29884618).; DOMAIN: The alpha-2 Ig-like domain mediates the interaction with CD4 coreceptor.
Domain (FT)
112..204; Ig-like C1-type
Region
26..109; Alpha-1; 110..203; Alpha-2; 204..216; Connecting peptide
Protein Families
MHC class II family
Sequence Similarities
Belongs to the MHC class II family.
Clinical Relevance
Interaction Protein
ENSG00000242574
Interaction Count
1
Interaction Dataset
biogrid_bioplex