Protein detail

MBP

Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)

Entry name MBP	UniProt ID P02686	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Candidate cardiovascular disease genesDisease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)

Protein Class

Candidate cardiovascular disease genesDisease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Candidate cardiovascular disease genes
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000197971

Entrez Gene Symbol

MBP

Gene Description

Myelin basic protein

Chromosome

Position

76978827-77133683

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificgallbladderCell SpecificCone photoreceptor cellsSingle-Nuclei Brain Specificamygdala excitatory

Function & Pathway

Protein Function

Candidate cardiovascular disease genes
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

KEGG

hsa04517 IgSF CAM signaling

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

57 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
MBP	PRKACA	P17612	S	122	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	13	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	133	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	148	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	151	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	159	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	162	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	177	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	188	phosphorylation	KEA	KEA:2413024
MBP	PRKACA	P17612	S	57	phosphorylation	KEA	KEA:2413024

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Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCA	P17252	MBP	P02686	Yes	Yes	No	WangPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007HINTKEACA1PhosphoSite_KEAHPRD_KEASIGNOR_ProtMapper	HINT:8375396 CA1:10460230 HPRD:2413024 KEA:2413024 ProtMapper:2413024 SIGNOR:2413024 HINT:15927069
KAPCA	P17612	MBP	P02686	Yes	No	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	SIGNOR:2413024 KEA:2413024 HPRD:2413024 ProtMapper:2413024
CN37	P09543	MBP	P02686	Yes	No	Yes	SIGNOR	SIGNOR:28076777
MK01	P28482	MBP	P02686	Yes	No	Yes	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEAphosphoELMSIGNOR_ProtMapperSPIKE_LC	SIGNOR:12760422 HINT:12588875 SIGNOR:16401070 HINT:12114318 ProtMapper:12760422 HPRD:15380617 KEA:15380617 BioGRID:11258664 HINT:22778266 ProtMapper:16401070 HINT:10371216 HINT:10958680 BioGRID:12944901 HPRD:12760422 HINT:8846788 HINT:11570821 BioGRID:10371216 HINT:10464310 SPIKE_LC:17255944 HINT:11258664 HINT:17255944 KEA:12760422 phosphoELM:1939237 HINT:10978313 KEA:1939237 HINT:17906618 HINT:11983899 ProtMapper:1939237 HPRD:9792705 HINT:12944901 HINT:9596579 HINT:14530346 SIGNOR:1939237
MK03	P27361	MBP	P02686	Yes	No	Yes	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDHINTPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:16401070 ProtMapper:1939237 HINT:19910486 phosphoELM:1939237 SIGNOR:16401070 HINT:21924351 HPRD:10339476 HINT:14530346 KEA:1939237 SIGNOR:1939237 HINT:17906618 HINT:11570821
UHMK1	Q8TAS1	MBP	P02686	Yes	No	Yes	phosphoELM_MIMPMIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapper	ProtMapper:10880969 ProtMapper:16401070 KEA:10880969 SIGNOR:16401070 phosphoELM:10880969 SIGNOR:10880969
KPCD1	Q15139	MBP	P02686	Yes	Yes	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetWangPhosphoSite	PhosphoSite:17939756

Protein Complex Composition

61 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster60	MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCMBP	P25205 P33991 P33992 P33993 P49736 Q14566 Q9BTE3	1:1:1:1:1:1:1	Compleathu.MAP2	Compleat:HC2722	22036573
MCM complex	MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCMBP MMS22L TONSL	P25205 P33991 P33992 P33993 P49736 Q14566 Q6ZRQ5 Q96HA7 Q9BTE3	1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2571	15538388 17296731
SMN complex	GEMIN7 GEMIN8 IGHMBP2	P38935 Q9H840 Q9NWZ8	1:1:1	Compleat	Compleat:HC3579	19299493 16434402
	ARHGEF37 BIN3 DNMBP FBXO8	A1IGU5 Q6XZF7 Q9NQY0 Q9NRD0	0:0:0:0	hu.MAP2
	ARHGEF37 BIN3 DNMBP PICK1	A1IGU5 Q6XZF7 Q9NQY0 Q9NRD5	0:0:0:0	hu.MAP
	CDC45 CDC5L CDC6 CDC7 CDT1 DBF4 H4C4 ILF2 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 SSRP1 TONSL	O00311 O43913 O43929 O75419 P15927 P25205 P27694 P33991 P33992 P33993 P49736 P62805 Q08945 Q12905 Q13415 Q13416 Q14566 Q7L590 Q96HA7 Q99459 Q99741 Q9BTE3 Q9H211 Q9UBD5 Q9UBU7 Q9Y5N6	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCFinder	Compleat:HC9693
	CLINT1 CLTCL1 GAK STAMBP	O14976 O95630 P53675 Q14677	0:0:0:0	hu.MAP
	CHMP1A CHMP1B CHMP2A CHMP3 CHMP4B CHMP5 GRAP2 PTPN23 STAMBP SYNJ2 UBC USP8 VPS4A VPS4B VTA1	O15056 O43633 O75351 O75791 O95630 P0CG48 P40818 Q7LBR1 Q9H3S7 Q9H444 Q9HD42 Q9NP79 Q9NZZ3 Q9UN37 Q9Y3E7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3677
	CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP5 NPC1 OSBPL5 STAMBP UBC USP8 VPS4A VPS4B VTA1	O15118 O43633 O75351 O95630 P0CG48 P40818 Q7LBR1 Q9BY43 Q9H0X9 Q9H444 Q9HD42 Q9NP79 Q9NZZ3 Q9UN37 Q9Y3E7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8329
	CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP5 IST1 STAMBP UBC USP8 VPS4A VPS4B VTA1 XYLB	O43633 O75191 O75351 O95630 P0CG48 P40818 P53990 Q7LBR1 Q9BY43 Q9H444 Q9HD42 Q9NP79 Q9NZZ3 Q9UN37 Q9Y3E7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8985

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	R Sequencing	2	27894104 38321535

Sequence, Structure & Domains

Sequences

Length

304

Mass

33,117

Sequence

MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR

Alternative Products

Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Golli-MBP1, HOG7; IsoId=P02686-1; Sequence=Displayed; Name=2; Synonyms=Golli-MBP2, HOG5; IsoId=P02686-2; Sequence=VSP_003311; Name=3; Synonyms=MBP1, 21.5 kDa; IsoId=P02686-3; Sequence=VSP_003308, VSP_003309; Name=4; Synonyms=MBP2, 20.2 kDa; IsoId=P02686-4; Sequence=VSP_003308, VSP_003309, VSP_003310; Name=5; Synonyms=MBP3, 18.5 kDa; IsoId=P02686-5; Sequence=VSP_003308; Name=6; Synonyms=MBP4, 17.2 kDa; IsoId=P02686-6; Sequence=VSP_003308, VSP_003310

Alternative Sequence

1..133; Missing (in isoform 3, isoform 4, isoform 5 and isoform 6); 192; K -> KVPWLKPGRSPLPSHARSQPGLCNMYK (in isoform 3 and isoform 4); 193..304; DSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR -> VSSEE (in isoform 2); 240..250; Missing (in isoform 4 and isoform 6)

3D Structural Models

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

1..12; Basic and acidic residues; 22..32; Basic and acidic residues; 51..65; Polar residues; 95..113; Basic and acidic residues; 117..130; Polar residues

Region

1..146; Disordered; 179..222; Induces experimental autoimmune encephalomyelitis (EAE) 1; 180..249; Disordered; 246..256; Induces experimental autoimmune encephalomyelitis (EAE) 2

Protein Families

Myelin basic protein family

Sequence Similarities

Belongs to the myelin basic protein family.

Clinical Relevance

Disease Involvement

Autoimmune encephalomyelitis

Related Diseases

Multiple sclerosis

Biomarker

Phase 2

Drug Targets

Clinical trial target

Drugs

BIOFLAVONOID INSULIN, REGULAR, HUMAN TIPLIMOTIDE PREDNISONE INTERFERON BETA-1A CYCLOSPORINE QUERCETIN

Antibody

CAB002300 HPA049222 HPA064368

Interaction Protein

ENSG00000144579ENSG00000163823ENSG00000169252ENSG00000169403

Interaction Count

Interaction Dataset

intact_biogrid