Protein detail

B3AT

Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233)

Protein symbol B3AT	UniProt ID P02730	EVMP score 0.38
Frequency	Transmembrane count 12	Protein classification Blood group antigen proteinsCD markersDisease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233)

Protein Class

Blood group antigen proteinsCD markersDisease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Urinary system diseases:Kidney diseases
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Blood group antigen proteins
CD markers
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Transmembrane

404..427; Helical; Name=1; 436..456; Helical; Name=2; 460..476; Discontinuously helical; Name=3; 486..506; Helical; Name=4; 519..541; Helical; Name=5; 571..591; Helical; Name=6; 603..623; Helical; Name=7; 664..684; Helical; Name=8; 701..719; Helical; Name=9; 720..737; Discontinuously helical; Name=10; 761..781; Helical; Name=11; 782..800; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000004939

Entrez Gene Symbol

SLC4A1

Gene Synonym

AE1CD233DIEPB3FRRTA1ASWWDWR

Gene Description

Solute carrier family 4 member 1 (Diego blood group)

Chromosome

Position

44248390-44268141

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificadipose tissueCell SpecificAdipocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor

Function & Pathway

Protein Function

Human disease related genes:Urinary system diseases:Kidney diseases
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Blood group antigen proteins
CD markers
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04966 Collecting duct acid secretion

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

38 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC4A1	CSNK1A1	P48729	Y	46	phosphorylation	KEA	KEA:1998697 KEA:91152059
SLC4A1	CSNK1A1	P48729	Y	8	phosphorylation	KEA	KEA:10942405 KEA:1998697 KEA:2065070
SLC4A1	LYN	P07948	Y	359	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10942405 KEA:10942405 SIGNOR:10942405 HPRD:2065070 KEA:2065070 phosphoELM:10942405 HPRD:10942405
SLC4A1	LYN	P07948	Y	904	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10942405 KEA:10942405 SIGNOR:10942405 HPRD:2065070 KEA:2065070 phosphoELM:10942405 HPRD:10942405
SLC4A1	LYN	P07948	Y	8	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	KEA:10942405 KEA:1998697 KEA:2065070 phosphoELM:10942405
SLC4A1	LYN	P07948	Y	21	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	KEA:10942405 KEA:1998697 KEA:2065070 phosphoELM:10942405
SLC4A1	LYN	P07948	Y	46	phosphorylation	PhosphoNetworks
SLC4A1	SYK	P43405	Y	359	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	KEA:10942405 HPRD:2065070 KEA:2065070 phosphoELM:10942405 HPRD:10942405
SLC4A1	SYK	P43405	Y	904	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	KEA:10942405 HPRD:2065070 KEA:2065070 phosphoELM:10942405 HPRD:10942405
SLC4A1	SYK	P43405	Y	8	phosphorylation	PhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10942405 KEA:10942405 KEA:1998697 ProtMapper:19306898 SIGNOR:10942405 KEA:2065070 phosphoELM:10942405

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Ligand-Receptor Signaling

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No
peripheral	peripheral	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
basolateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KSYK	P43405	B3AT	P02730	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phos	HPRD:16118313 PhosphoSite:21951684 HPRD-phos:2065070 ProtMapper:1998697 HPRD-phos:10942405 PhosphoSite:15649129 phosphoELM:10942405 PhosphoSite:1998697 PhosphoSite:12070037 KEA:10942405 PhosphoSite:17404032 HPRD:2065070 HPRD:1998697 PhosphoSite:2065070 PhosphoSite:27856737 ProtMapper:2065070 PhosphoSite:18827007 ProtMapper:10942405 KEA:1998697 PhosphoSite:10942405 ProtMapper:19306898 SIGNOR:10942405 PhosphoSite:6681814 KEA:2065070 HPRD:10942405
LYN	P07948	B3AT	P02730	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos	HPRD:16118313 ProtMapper:10942405 KEA:10942405 KEA:1998697 HPRD:10942405 ProtMapper:1998697 HPRD-phos:2065070 PhosphoSite:32517126 ProtMapper:2065070 SIGNOR:10942405 HPRD-phos:10942405 HPRD:2065070 PhosphoSite:32411010 KEA:2065070 phosphoELM:10942405 HPRD:1998697
KC1A	P48729	B3AT	P02730	Yes	No	No	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	KEA:10942405 KEA:1998697 KEA:9108423 PhosphoSite:9108423 KEA:91152059 KEA:2065070 iPTMnet:9108423 phosphoELM:9108423

Protein Complex Composition

12 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC4A11	Q8NBS3	2	PDB	PDB:7x1hPDB:7x1jPDB:7x1iPDB:7x1g
	SLC4A1AP	Q9BWU0	2	PDB	PDB:4h87

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	12	32089743 39766158 39940641 36398564 37786918 40748658 34817906 28986585 27605433 38321535 40089067 29148239

Sequence, Structure & Domains

Sequences

Length

911

Mass

101,792

Sequence

MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=eAE1, Erythrocyte; IsoId=P02730-1; Sequence=Displayed; Name=2; Synonyms=kAE1, Kidney; IsoId=P02730-2; Sequence=VSP_057833

Alternative Sequence

1..65; Missing (in isoform 2)

3D Structural Models

Turn

643..645; 799..802

Helix

5..7; 9..16; 18..21; 43..46; 104..115; 128..141; 147..149; 150..157; 164..169; 195..200; 212..219; 278..290; 292..300; 304..316; 329..332; 333..335; 336..347; 380..389; 390..392; 395..398; 403..431; 437..454; 466..481; 486..506; 509..515; 518..546; 570..593; 599..607; 609..622; 661..666; 668..689; 692..694; 702..718; 728..737; 761..772; 773..775; 777..780; 785..798; 804..811; 816..818; 823..826; 830..851; 854..858; 859..864; 866..872; 874..877; 880..886

Beta Strand

58..66; 68..70; 73..88; 90..92; 118..123; 173..175; 180..185; 188..190; 226..234; 241..251; 256..258; 262..270; 319..321; 350..352; 433..435; 460..463; 560..562; 594..597; 636..638; 655..657; 725..727; 739..741; 753..756

3D Structure

Electron microscopy (38); NMR spectroscopy (10); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

1..26; Acidic residues

Region

1..40; Disordered; 13..31; (Microbial infection) Interaction with P.falciparum (isolate K1) FBPA; 55..290; Globular; 176..185; Interaction with ANK1; 304..357; Dimerization arm; 559..630; Involved in anion transport; 720..761; (Microbial infection) 5ABC region; interaction with P.falciparum (isolate 3D7) MSP9

Protein Families

Anion exchanger (TC 2.A.31) family

Sequence Similarities

Belongs to the anion exchanger (TC 2.A.31) family.

Clinical Relevance

Disease Involvement

Disease variantElliptocytosisHereditary hemolytic anemia

Drugs

METOPROLOL ATENOLOL

Antibody

HPA015584 CAB034438 HPA063911

Interaction Protein

ENSG00000147889

Interaction Count

Interaction Dataset

intact_biogrid