Protein detail
TFR1
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (Transferrin receptor 1) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Protein symbol TFR1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (Transferrin receptor 1) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Peptidases:Metallopeptidases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
68..88; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD71p90TFR1
Gene Description
Transferrin receptor
Chromosome
3
Position
196012511-196082153
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Peptidases:Metallopeptidases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0030669 clathrin-coated endocytic vesicle membrane
- GO:0031410 cytoplasmic vesicle
- GO:0042470 melanosome
- GO:0043231 intracellular membrane-bounded organelle
- GO:0048471 perinuclear region of cytoplasm
- GO:0055037 recycling endosome
- GO:0055038 recycling endosome membrane
- GO:0070062 extracellular exosome
- GO:0072562 blood microparticle
- GO:0098944 postsynaptic recycling endosome membrane
- GO:0098978 glutamatergic synapse
- GO:1903561 extracellular vesicle
- GO:1990712 HFE-transferrin receptor complex
Molecular Function
- GO:0001618 virus receptor activity
- GO:0003723 RNA binding
- GO:0003725 double-stranded RNA binding
- GO:0004998 transferrin receptor activity
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0030544 Hsp70 protein binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0044877 protein-containing complex binding
Biological Process
KEGG
Reactome
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9725554 differentiation of keratinocytes in interfollicular epidermis in mammalian skin
- R-hsa-432722 golgi associated vesicle biogenesis
- R-hsa-917937 iron uptake and transport
- R-hsa-199991 membrane trafficking
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9013407 rhoh gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696270 rnd2 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-917977 transferrin endocytosis and recycling
- R-hsa-382551 transport of small molecules
- R-hsa-199992 trans golgi network vesicle budding
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TFRC | PRKCA | P17252 | S | 24 | phosphorylation | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | ProtMapper:15212693phosphoELM:3013873KEA:3013873KEA:17570479phosphoELM:3119581KEA:86250833KEA:3119581 |
| TFRC | PRKCA | P17252 | T | 653 | phosphorylation | PhosphoNetworks | |
| TFRC | SRC | P12931 | Y | 20 | phosphorylation | RLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:21859709 |
| TFRC | PRKCB | P05771 | S | 24 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| TFRC | PRKCG | P05129 | S | 24 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| TFRC | PRKCD | Q05655 | S | 24 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| TFRC | PRKCE | Q02156 | S | 24 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | Yes | Yes | No |
| transferrin | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | Yes | Yes | No |
| transferrin | receptor | HPMR | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SH3B4 | Q9P0V3 | TFR1 | P02786 | Yes | No | Yes | DOMINOSIGNORIntActWangLit-BM-17 | Lit-BM-17:16325581SIGNOR:16325581IntAct:16325581 |
| KPCA | P17252 | TFR1 | P02786 | Yes | No | No | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMPhosphoSiteNetworKIN_KEA | ProtMapper:15212693phosphoELM:3013873PhosphoSite:3119581PhosphoSite:3013873KEA:3013873KEA:17570479phosphoELM:3119581KEA:86250833PhosphoSite:3129437KEA:3119581 |
| SRC | P12931 | TFR1 | P02786 | Yes | No | No | iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21859709ProtMapper:21859709 |
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_SC_Cluster308 | CPQNAALAD2NAALADL1TFR2TFRCUBA1UBA6UBA7 | A0AVT1P02786P22314P41226Q9UP52Q9UQQ1Q9Y3Q0Q9Y646 | 1:1:1:1:1:1:1:1 | Compleat | Compleat:HC3111 | |
| SNX complex (SNX1SNX1aTFRC) | SNX1TFRC | P02786Q13596 | 0:0 | CORUM | CORUM:1104 | 9819414 |
| SNX complex (SNX1aSNX2SNX4TFRC) | SNX1SNX2SNX4TFRC | O60749O95219P02786Q13596 | 1:1:1:1 | Compleat | Compleat:HC2965 | 9819414 |
| TF-TFRC complex | TFTFRC | P02786P02787 | 2:2 | KEGG-MEDICUSCORUMPDB | PDB:1suvPDB:3s9mCORUM:7359PDB:3s9nPDB:3s9l | 14980223 |
| TFRC | P02786 | 8 | PDB | PDB:6wrxPDB:6wrwPDB:2nsuPDB:6w3hPDB:7zqsPDB:6okdPDB:6y76PDB:1cx8PDB:6wrv | ||
| ESR1TFTFRC | P02786P02787P03372 | 1:1:1 | CompleatCFinder | Compleat:HC6827 | ||
| FTH1TFRC | P02786P02794 | 2:24 | PDB | PDB:6gsrPDB:6h5i | ||
| GJB2TFRC | P02786P29033 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 0 |
Sequence, Structure & Domains
Sequences
Length
760
Mass
84,871
Sequence
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
3D Structural Models
Turn
205..208; 285..287; 416..419; 469..473; 516..518; 564..567; 679..682; 692..694; 700..702
Helix
124..136; 141..146; 150..152; 160..175; 195..197; 240..245; 264..273; 317..319; 339..346; 355..357; 420..440; 456..458; 461..468; 474..476; 500..502; 503..510; 528..531; 541..546; 573..579; 583..602; 613..626; 629..634; 640..662; 668..678; 683..685; 709..718; 728..748; 753..755
Beta Strand
179..192; 199..204; 209..214; 220..222; 226..230; 232..234; 236..238; 253..259; 260..262; 278..282; 303..306; 308..310; 311..313; 334..336; 349..352; 364..367; 372..377; 380..393; 396..408; 411..413; 445..454; 478..483; 491..498; 512..514; 520..522; 552..558; 603..606; 688..690; 705..708; 719..723; 750..752
3D Structure
Electron microscopy (8); X-ray crystallography (14)
Domain & Motif Annotations
Motif
20..23; Endocytosis signal; 58..61; Stop-transfer sequence; 646..648; Cell attachment site; required for binding to transferrin
Domain (FT)
223..313; PA
Region
1..67; Mediates interaction with SH3BP4; 569..760; Ligand-binding
Protein Families
- Peptidase M28 family
- M28B subfamily
Sequence Similarities
Belongs to the peptidase M28 family. M28B subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Biomarker
Phase 1/2; Phase 1
Drug Targets
FDA approved drug targetsClinical trial target
Interaction Protein
ENSG00000010704ENSG00000136381ENSG00000167461
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencell