Protein detail

CYTB

Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)

Protein symbol CYTB	UniProt ID P04080	EVMP score 0.75
Frequency 31	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted secreted proteins

Basic Information

Protein Names

Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)

Protein Class

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted secreted proteins

Protein Function

Disease related genes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Congenital malformations:Congenital malformations of skin
Predicted secreted proteins

Ensembl

ENSG00000175315

Entrez Gene Symbol

CST6

Gene Description

Cystatin E/M

Chromosome

Position

66012008-66013505

Frequency

EVMP Score

0.75

Fluorescence & Localization

Function & Pathway

Protein Function

Disease related genes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Congenital malformations:Congenital malformations of skin
Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CST6	Q15828	2	PDB	PDB:4n6mPDB:6fk0
	CST6 LGMN	Q15828 Q99538	1:1	PDB	PDB:4n6nPDB:4n6o

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	2	38576002 38795909

Sequence, Structure & Domains

Sequences

Length

Mass

11,140

Sequence

MMCGAPSATQPATAETQHIADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKPLTLSNYQTNKAKHDELTYF

3D Structural Models

Helix

14..31

Beta Strand

39..58; 60..62; 64..74; 80..89

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Motif

46..50; Secondary area of contact

Protein Families

Cystatin family

Sequence Similarities

Belongs to the cystatin family.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantEctodermal dysplasia

Antibody

CAB019316 HPA044963