Protein detail
ANXA1
Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
Protein symbol ANXA1 | UniProt ID | EVMP score 0.63 |
Frequency 10 | Transmembrane count | Protein classification Cancer-related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
Protein Class
Cancer-related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Transporter channels and pores
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ANX1LPC1
Gene Description
Annexin A1
Chromosome
9
Position
73151865-73170393
Frequency
10
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificdeep-layer near-projecting
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Transporter channels and pores
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0001533 cornified envelope
- GO:0001891 phagocytic cup
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005768 endosome
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0009986 cell surface
- GO:0012506 vesicle membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0031514 motile cilium
- GO:0031901 early endosome membrane
- GO:0031982 vesicle
- GO:0042383 sarcolemma
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
Molecular Function
- GO:0001786 phosphatidylserine binding
- GO:0005102 signaling receptor binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005543 phospholipid binding
- GO:0005544 calcium-dependent phospholipid binding
- GO:0008289 lipid binding
- GO:0019834 phospholipase A2 inhibitor activity
- GO:0048306 calcium-dependent protein binding
- GO:0098641 cadherin binding involved in cell-cell adhesion
Biological Process
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9925563 developmental lineage of pancreatic ductal cells
- R-hsa-444473 formyl peptide receptors bind formyl peptides and many other ligands
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-416476 g alpha q signalling events
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-397014 muscle contraction
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-449147 signaling by interleukins
- R-hsa-445355 smooth muscle contraction
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
29 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ANXA1 | PRKCE | Q02156 | S | 28 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ANXA1 | PRKCE | Q02156 | T | 24 | phosphorylation | MIMPphosphoELM_MIMP | |
| ANXA1 | PRKCI | P41743 | S | 27 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:2457390 |
| ANXA1 | PRKX | P51817 | T | 216 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ANXA1 | PRKY | O43930 | T | 216 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ANXA1 | EGF | P01133 | Y | 21 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| ANXA1 | ERBB3 | P21860 | Y | 21 | phosphorylation | KEA | KEA:17570479 |
| ANXA1 | HCK | P08631 | Y | 21 | phosphorylation | KEA | KEA:17570479 |
| ANXA1 | IGF1R | P08069 | Y | 21 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | Yes | No | No |
| ligand | ligand | talklr | Yes | No | Yes | No | No |
| ligand | ligand | scConnect | Yes | No | Yes | No | No |
| ligand | ligand | connectomeDB2020 | Yes | No | Yes | No | No |
| ligand | ligand | iTALK | Yes | No | Yes | No | No |
| ligand | ligand | EMBRACE | Yes | No | Yes | No | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | No | No |
| ligand | ligand | ICELLNET | Yes | No | Yes | No | No |
| ligand | ligand | CellChatDB | Yes | No | Yes | No | No |
| ligand | ligand | CellTalkDB | Yes | No | Yes | No | No |
Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EGFR | P00533 | ANXA1 | P04083 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperdbPTMHINTPhosphoSite_KEAphosphoELM_KEALit-BM-17HPRDIntActPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LC | HINT:20029029Lit-BM-17:15581623PhosphoSite:2457390HINT:15581623Lit-BM-17:24189400PhosphoSite:24782913KEA:2457390ProtMapper:34208346SIGNOR:24103589IntAct:20029029ProtMapper:24103589dbPTM:17081983dbPTM:2457390phosphoELM:2457390ProtMapper:9223619PhosphoSite:16052208Lit-BM-17:20029029IntAct:31980649SPIKE_LC:15581623IntAct:15581623HPRD:15581623KEA:3020049 |
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Protein Complex Composition
11 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANXA11C19orf47CAAP1CCDC9BCHTOPDDX39BDNAI1FYTTD1NCBP3POLDIP3RBM33SARNPTHOC1THOC2THOC3THOC5THOC6THOC7ZC3H11A | O75152P50995P82979Q13769Q13838Q53F19Q6I9Y2Q6ZUT6Q86W42Q8N9M1Q8NI27Q96EV2Q96FV9Q96J01Q96QD9Q9BY77Q9H8G2Q9UI46Q9Y3Y2 | 0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| ANXA11COL3A1 | P02461P50995 | 0:0 | hu.MAP | |||
| ANXA1FPR2 | P04083P25090 | 0:0 | Cellinker | |||
| ANXA1CRNNSPRR3 | P04083Q9UBC9Q9UBG3 | 0:0:0 | hu.MAP | |||
| ANXA11ATP5MECCDC68RPS21SLC25A5 | P05141P50995P56385P63220Q9H2F9 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_446 | ||
| ANXA11ANXA7 | P20073P50995 | 0:0 | hu.MAP2 | |||
| ANXA11ANXA7MOB1A | P20073P50995Q9H8S9 | 0:0:0 | hu.MAP2 | |||
| ANXA13 | P27216 | 3 | PDB | PDB:6b3i | ||
| ANXA11TARDBP | P50995Q13148 | 6:6 | PDB | PDB:9forPDB:9fof | ||
| ANXA11DNAI1THOC6 | P50995Q86W42Q9UI46 | 0:0:0 | hu.MAP2 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa) | 16 | 38590132379267563606464738113368373224753330447841068253335925003801459530915084329169863614683438207106390017003698231237670049 |
Sequence, Structure & Domains
Sequences
Length
346
Mass
38,714
Sequence
MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN
3D Structural Models
Helix
3..10; 16..18; 46..55; 65..71; 77..87; 94..99; 106..109; 110..112
Beta Strand
62..64
3D Structure
NMR spectroscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Repeat
42..113; Annexin 1; 114..185; Annexin 2; 197..269; Annexin 3; 273..344; Annexin 4
Domain (CC)
The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
Protein Families
Annexin family
Sequence Similarities
Belongs to the annexin family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Drug Targets
FDA approved drug targetsLiterature-reported targetClinical trial target
Drugs
HALOBETASOLSTAUROSPORINEDEXAMETHASONEDNPAFLUMETHASONE PIVALATEHYDROCORTAMATEDESOXIMETASONERFRP-3PANCREATIC POLYPEPTIDECLOBETASOL1DMEPREDNISONEPREDNISOLONETHERAPEUTIC GLUCOCORTICOIDBIBP3226DESONIDEPREDNICARBATERIMEXOLONECOMPOUND 46 [PMID: 25268943]PHORBOL 12-MYRISTATE 13-ACETATEEFWSLAAPQRF-NH2METHYLPREDNISOLONEMOMETASONE[3H]EYFST 638CLOCORTOLONE[125I]NPFFDIFLORASONE DIACETATE[125I]EYFTHERAPEUTIC CORTICOSTEROIDAC263093RITUXIMABY-RFRP-3BETAMETHASONETRIAMCINOLONETETRADECANOYLPHORBOL ACETATEBECLOMETHASONEHYDROCORTISONE BUTYRATE4-PHENYLENEDIAMINELOTEPREDNOLRF9NEUROPEPTIDE FFALCLOMETASONEAMCINONIDE
Interaction Protein
ENSG00000137275ENSG00000146648ENSG00000269335
Interaction Count
3
Interaction Dataset
intact_biogrid