Protein detail

NTRK1

High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)

Protein symbol
NTRK1
UniProt ID
P04629
EVMP score
0.25
Frequency
1
Transmembrane count
1
Protein classification
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Basic Information
Protein Names
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Transmembrane
424..439; Helical
Transmembrane Count
1
Ensembl
ENSG00000198400
Entrez Gene Symbol
NTRK1
Gene Synonym
MTCTRKTRKA
Gene Description
Neurotrophic receptor tyrosine kinase 1
Chromosome
1
Position
156815636-156881850
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificNeutrophil progenitorsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

22 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
NTRK1INSRP06213Y676phosphorylationKEAKEA:17570479
NTRK1INSRP06213Y680phosphorylationKEAKEA:17570479
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Ligand-Receptor Signaling

66 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorCellPhoneDBNoYesNoYesNo
receptorreceptorGO_IntercellNoYesNoYesNo
receptorreceptorHPMRNoYesNoYesNo
receptorreceptorICELLNETNoYesNoYesNo
receptorreceptorCellChatDBNoYesNoYesNo
receptorreceptorCellTalkDBNoYesNoYesNo
receptorreceptorSurfaceomeNoYesNoYesNo
receptorreceptorRamilowski2015NoYesNoYesNo
receptorreceptorKirouac2010NoYesNoYesNo
receptorreceptorLRdbNoYesNoYesNo
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Regulatory Interaction Network

22 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
NTRK1P04629SHC1P29353YesYesNoHPRD_MIMPSIGNORHINTSignaLink3Li2012Lit-BM-17HPRDCui2007CA1LMPIDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointELMSPIKE_LCSPIKEHINT:10092678Lit-BM-17:25921289SignaLink3:7541035SPIKE:8155326SPIKE_LC:8226808HINT:8226808CA1:8226808ELM:8524391HPRD:8155326SignaLink3:10629055SignaLink3:10092678SignaLink3:8183561Lit-BM-17:12446789SignaLink3:9856458SPIKE:8226808SPIKE_LC:8155326CA1:8552402HPRD:10629055Lit-BM-17:8226808Lit-BM-17:10092678HINT:8524391SIGNOR:10708759HPRD:7541035SignaLink3:23331499HINT:12446789LMPID:8226808SignaLink3:8155326CA1:15056278Lit-BM-17:10708759HINT:10708759CA1:9715270Lit-BM-17:9856458Lit-BM-17:8183561HPRD:8226808SignaLink3:8226808LMPID:8524391LMPID:7537849HINT:9856458
NGFP01138NTRK1P04629YesYesNoiTALKKirouac2010SIGNORProtMapperHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007CA1IntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020AlzPathwaySPIKE_LCLRdbSPIKELit-BM-17:10713102ProtMapper:12067229ProtMapper:25611061ProtMapper:28090201connectomeDB2020:10490030HINT:10490030CA1:9290260SPIKE_LC:17145710DIP:10490030HPRD:10490030AlzPathway:17404842HINT:11729324Lit-BM-17:10490030SPIKE:17145710Baccin2019:10490030SPIKE:8155326HINT:14985763Lit-BM-17:11738045DIP:9083066Lit-BM-17:1849459CA1:9547236Lit-BM-17:14985763Cellinker:10490030ProtMapper:29325876LRdb:15DIP:1849459ProtMapper:31871542ProtMapper:30808933HINT:17196528Lit-BM-17:9083066AlzPathway:9775403BioGRID:10490030Cellinker:27908981IntAct:10490030Lit-BM-17:9857023SPIKE_LC:8155326ProtMapper:22666365Cellinker:14985763DIP:10713102CA1:1706478Lit-BM-17:11729324HPMR:10490030ProtMapper:23772401Baccin2019:14985763SPIKE:14985763Cellinker:24224055IntAct:14985763connectomeDB2020:14985763LRdb:10490030SIGNOR:11114882DIP:9857023SPIKE_LC:14985763HPRD:14985763ProtMapper:17409494ProtMapper:19126759ProtMapper:27229480HINT:11738045CellChatDB:27908981CellTalkDB:10490030
NTRK1P04629NGFP01138YesYesNoHPMRWangPhosphoPointHPRDCui2007AlzPathwayHINTBioGRIDSignaLink3IntActDIPSPIKE_LCLit-BM-17SPIKECellCallLit-BM-17:10713102HINT:10490030SPIKE_LC:17145710SignaLink3:11729324DIP:10490030HPRD:10490030AlzPathway:17404842HINT:11729324Lit-BM-17:10490030SPIKE:17145710SPIKE:8155326HINT:14985763Lit-BM-17:11738045DIP:9083066Lit-BM-17:1849459Lit-BM-17:14985763SignaLink3:11738045DIP:1849459HINT:17196528Lit-BM-17:9083066AlzPathway:9775403BioGRID:10490030IntAct:10490030Lit-BM-17:9857023SPIKE_LC:8155326DIP:10713102Lit-BM-17:11729324HPMR:10490030SignaLink3:23331499IntAct:14985763SignaLink3:21071413SignaLink3:10490030DIP:9857023HPRD:14985763HINT:11738045SignaLink3:14985763
NTRK1P04629FRS2Q8WU20YesYesNoPhosphoPointSIGNORHPRDSignaLink3WangLit-BM-17HPRD:10092678Lit-BM-17:10092678SignaLink3:10092678SIGNOR:10092678SignaLink3:23331499SignaLink3:21071413
NTRK1P04629PLCG1P19174YesYesNoPhosphoPointSIGNORHPRDCui2007HINTSignaLink3BioGRIDCA1IntActLi2012WangLit-BM-17HINT:10092678Lit-BM-17:25921289Lit-BM-17:1715690HPRD:8384556IntAct:8384556HINT:8384556SignaLink3:10708759Lit-BM-17:8384556SignaLink3:10092678HINT:1715690BioGRID:1400471CA1:8552402SignaLink3:18988627HPRD:1715690Lit-BM-17:10092678BioGRID:1715690SIGNOR:8384556SignaLink3:8384556SIGNOR:10708759SignaLink3:23331499Lit-BM-17:10708759HINT:10708759HINT:1400471SignaLink3:21071413SignaLink3:1715690Lit-BM-17:9856458HINT:9856458
NTRK1P04629ABL1P00519YesYesNoSIGNORHPRDSignaLink3BioGRIDLit-BM-17SignaLink3:10679771SignaLink3:10708759Lit-BM-17:10679771SIGNOR:10708759HPRD:10708759SignaLink3:23331499Lit-BM-17:10708759HPRD:10679771BioGRID:10679771
NTRK1P04629GRAPQ13588YesYesNoSignaLink3SignaLink3:11733534SignaLink3:23331499
NTRK1P04629MATKP42679YesYesNoPhosphoPointHPRDSignaLink3WangLit-BM-17SignaLink3:10329710Lit-BM-17:10329710HPRD:10329710SignaLink3:23331499
NTRK1P04629RHG32A7KAX9YesYesNoSIGNORPhosphoPointCui2007SignaLink3CA1WangLit-BM-17CA1:12446789SignaLink3:12446789Lit-BM-17:25921289Lit-BM-17:12446789SignaLink3:23331499SIGNOR:12446789
SQSTMQ13501NTRK1P04629YesYesNoHPRDHINTSignaLink3BioGRIDInnateDBInnateDB:12471037HPRD:11244088SignaLink3:18457658SignaLink3:18174161BioGRID:11244088SignaLink3:12471037SignaLink3:23331499HINT:17389358HINT:12471037HPRD:10747026
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Protein Complex Composition

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
NGF-TrkA complexNGFNTRK1P01138P046292:2CompleatCORUMPDBPDB:1wwwCORUM:5407PDB:2ifgCompleat:HC134510490030
NTRK1P046292PDBPDB:6iqnPDB:8ytePDB:4f0iPDB:2n90PDB:1wwaPDB:4aojPDB:6dkwPDB:6pmePDB:7n3t
NTRK1SHC1P04629P293531:1PDBPDB:1shc

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry130875722
Sequence, Structure & Domains

Sequences

Length
796
Mass
87,497
Sequence
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=TrkA-I and TrkA-II isoforms have similar biological properties but are differentially expressed.; Name=TrkA-II; Synonyms=TrkAII; IsoId=P04629-1; Sequence=Displayed; Name=TrkA-I; Synonyms=TrkAI; IsoId=P04629-2; Sequence=VSP_002899; Name=3; IsoId=P04629-3; Sequence=VSP_041905, VSP_002899; Name=TrkA-III; Synonyms=TrkAIII; IsoId=P04629-4; Sequence=VSP_042152, VSP_002899
Alternative Sequence
1..71; MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTEL -> MKEAALICLAPSVPPILTVKSWDTMQLRAARSRCTNLLAAS (in isoform 3); 192..284; GVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF -> V (in isoform TrkA-III); 393..398; Missing (in isoform TrkA-I, isoform 3 and isoform TrkA-III)

3D Structural Models

Turn
44..46; 108..113; 494..496; 534..536; 684..686; 722..724; 727..730; 749..751
Helix
55..59; 65..67; 84..87; 132..135; 154..156; 157..165; 170..173; 183..185; 256..258; 353..355; 418..441; 490..492; 498..501; 507..509; 552..566; 597..603; 608..611; 624..643; 653..655; 660..662; 672..675; 677..679; 691..693; 696..701; 706..721; 733..742; 754..763; 768..770; 774..786; 789..793
Beta Strand
37..43; 47..50; 70..74; 80..82; 95..101; 119..121; 141..144; 180..182; 195..199; 211..218; 224..229; 234..243; 246..253; 263..268; 273..278; 282..290; 294..309; 312..317; 320..323; 326..332; 342..350; 357..365; 368..376; 476..478; 510..517; 520..522; 524..533; 537..545; 575..579; 581..584; 586..590; 605..607; 615..617; 619..621; 646..648; 656..659; 663..666; 680..683; 687..689
3D Structure
NMR spectroscopy (3); X-ray crystallography (62)

Domain & Motif Annotations

Repeat
90..113; LRR 1; 116..137; LRR 2
Motif
537..541; DXXLL; 607..611; DXXLL
Domain (CC)
The transmembrane domain mediates interaction with KIDINS220..; DOMAIN: The extracellular domain mediates interaction with NGFR.
Domain (FT)
148..193; LRRCT; 194..283; Ig-like C2-type 1; 299..365; Ig-like C2-type 2; 510..781; Protein kinase
Region
469..490; Interaction with SQSTM1
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • Insulin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Drug Targets
FDA approved drug targets
Drugs
REPOTRECTINIBTAVILERMIDESELITRECTINIBNULLRADICICOLVITAMIN B6ACETYLCYSTEINECRIZOTINIBAST-487ANESTHETIC AGENTIMATINIBTHERAPEUTIC ANDROSTANOLONEDEXAMETHASONELAROTRECTINIBASPIRINESTRADIOL VALERATEMETHOTREXATEGAMMA-INTERFERONAZD-7451LESTAURTINIBLAROTRECTINIB SULFATECYTARABINEPILOCARPINE HYDROCHLORIDESURAMINTAMOXIFENCHEMBL:CHEMBL546797ENTRECTINIBGW441756XGAMBOGIC AMIDETHYROXINEGAMBOGIC ACIDMILCICLIBALISERTIBANTIESTROGENPD-0166285SP-600125GZ-389988PEGCANTRATINIBDOVITINIBGLUCARPIDASECENEGERMIN-BKBJREGORAFENIBSTREPTOZOCINALTIRATINIBTHERAPEUTIC GLUCOCORTICOIDCEP-2563 DIHYDROCHLORIDEILORASERTIBWORTMANNINTALETRECTINIBCEP-2563PLX-7486AZD-6918RECOMBINANT CYTOKINEANTINEOPLASTIC AGENTAPAZIQUONETHERAPEUTIC ANDROGENSORAFENIBPRASUGRELCYCLOPHOSPHAMIDE ANHYDROUSHESPERADINRG-1530ENMD-2076GW843682XBMS-754807TOZASERTIBGW-2580ONO-7579IL-6PHENYLEPHRINENERVE GROWTH FACTORPLX7486TRK INHIBITORPF-562271
Antibody
CAB004606HPA035799HPA076570CAB080140
Interaction Protein
ENSG00000096384ENSG00000134243ENSG00000134259ENSG00000140538ENSG00000161011
Interaction Count
5
Interaction Dataset
intact_biogrid