Protein detail
CY24B
NADPH oxidase 2 (EC 1.6.3.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Cytochrome b-245 heavy chain) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome)
Protein symbol CY24B | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
NADPH oxidase 2 (EC 1.6.3.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Cytochrome b-245 heavy chain) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Potential drug targets
- Transporters:Transport Electron Carriers
Transmembrane
10..36; Helical; 47..72; Helical; 96..130; Helical; 164..194; Helical; 204..222; Helical; 268..285; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
CGDGP91-PHOXNOX2
Gene Description
Cytochrome b-245 beta chain
Chromosome
X
Position
37780018-37813461
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificBreast lactating cells
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Potential drug targets
- Transporters:Transport Electron Carriers
Cellular Component
- GO:0005635 nuclear envelope
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0030425 dendrite
- GO:0030670 phagocytic vesicle membrane
- GO:0034702 monoatomic ion channel complex
- GO:0035579 specific granule membrane
- GO:0043020 NADPH oxidase complex
- GO:0043025 neuronal cell body
- GO:0070821 tertiary granule membrane
- GO:0097038 perinuclear endoplasmic reticulum
Molecular Function
Biological Process
KEGG
- hsa04066 HIF-1 signaling pathway
- KEGG:hsa04145 Phagosome
- KEGG:hsa04216 Ferroptosis
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04621 NOD-like receptor signaling pathway
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05020 Prion disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05415 Diabetic cardiomyopathy
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236973 cross presentation of particulate exogenous antigens phagosomes
- R-hsa-3299685 detoxification of reactive oxygen species
- R-hsa-168249 innate immune system
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-5668599 rho gtpases activate nadph oxidases
- R-hsa-9012999 rho gtpase cycle
- R-hsa-195258 rho gtpase effectors
- R-hsa-1222556 ros and rns production in phagocytes
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-194138 signaling by vegf
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| NADPH oxidase complex | CYBACYBBNCF1NCF2NCF4NOX1NOX3NOXA1NOXO1 | P04839P13498P14598P19878Q15080Q86UR1Q8NFA2Q9HBY0Q9Y5S8 | 1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC3419 | 82800523305576127169101763037793800816636067 |
| Phagocyte NADPH oxidase complex | CYBBNCF1NCF2NCF4RAC1 | P04839P14598P19878P63000Q15080 | 0:0:0:0:0 | SIGNOR | SIGNOR:SIGNOR-C557 | |
| Phagocyte NADPH oxidase complexRAC1 variant | CYBACYBBNCF1NCF2NCF4RAC1 | P04839P13498P14598P19878P63000Q15080 | 1:1:1:1:1:1 | ComplexPortal | PDB:1E96intact:EBI-13642011PDB:1w70PDB:1wlpPDB:1OEY | 16326715147552922704883024598074 |
| Phagocyte NADPH oxidase complexRAC2 variant | CYBACYBBNCF1NCF2NCF4RAC2 | P04839P13498P14598P15153P19878Q15080 | 1:1:1:1:1:1 | ComplexPortal | PDB:1E96PDB:1w70PDB:1wlpPDB:1OEYintact:EBI-25820331 | 16326715147552922704883024598074 |
| Phagocyte NADPH oxidase complexRAC3 variant | CYBACYBBNCF1NCF2NCF4RAC3 | P04839P13498P14598P19878P60763Q15080 | 1:1:1:1:1:1 | ComplexPortal | PDB:1E96intact:EBI-25820477PDB:1w70PDB:1wlpPDB:1OEY | 16326715147552922704883024598074 |
| CYBACYBB | P04839P13498 | 1:1 | PDB | PDB:8x2lPDB:7u8gPDB:8gz3 | ||
| CYBACYBBNCF1NCF2RAC1 | P04839P13498P14598P19878P63000 | 1:1:1:1:1 | PDB | PDB:8wej | ||
| CYBACYBBNCF2NCF4 | P04839P13498P19878Q15080 | 1:1:1:1 | CompleatCFinder | Compleat:HC6870 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF] | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
570
Mass
65,336
Sequence
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF
3D Structural Models
Turn
69..71; 221..225; 251..253; 304..306; 330..332; 448..451
Helix
5..32; 37..39; 40..46; 49..67; 73..82; 88..93; 94..96; 97..130; 136..143; 164..172; 174..192; 195..200; 202..209; 212..220; 233..238; 241..244; 248..250; 269..292; 360..368; 379..381; 393..398; 410..412; 413..429; 452..467; 485..493; 516..526; 540..552
Beta Strand
228..231; 262..264; 296..303; 307..313; 324..328; 338..342; 348..356; 386..391; 401..409; 431..433; 438..446; 473..480; 501..503; 509..512; 531..538; 556..560; 562..566
3D Structure
Electron microscopy (5); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
54..286; Ferric oxidoreductase; 287..397; FAD-binding FR-type
Clinical Relevance
Disease Involvement
Chronic granulomatous diseaseDisease variant
Antibody