Protein detail
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Entry name GNAI2 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 43 | Transmembrane count | Protein classification Human disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Guanine nucleotide-binding protein G(i) subunit alpha-2 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Protein Class (2)
Human disease related genesPredicted intracellular proteins
Protein Function (3)
- Human disease related genes:Cancers:Cancers of endocrine organs
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
GIPGNAI2B
Gene Description
G protein subunit alpha i2
Chromosome
3
Position
50226292-50259362
Supporting publications (n)
43
EVMP confidence score
0.88
Fluorescence & Localization
Cell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (3)
- Human disease related genes:Cancers:Cancers of endocrine organs
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
Cellular Component (14)
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005813 centrosome
- GO:0005829 cytosol
- GO:0005834 heterotrimeric G-protein complex
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0030425 dendrite
- GO:0030496 midbody
- GO:0044297 cell body
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Molecular Function (6)
Biological Process (3)
KEGG (43)
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04371 Apelin signaling pathway
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Reactome (27)
- R-hsa-170670 adenylate cyclase inhibitory pathway
- R-hsa-9660821 adora2b mediated anti inflammatory cytokines production
- R-hsa-392170 adp signalling through p2y purinoceptor 12
- R-hsa-400042 adrenaline noradrenaline inhibits insulin secretion
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-8939211 esr mediated signaling
- R-hsa-9009391 extra nuclear estrogen signaling
- R-hsa-977444 gaba b receptor activation
- R-hsa-977443 gaba receptor activation
- R-hsa-9634597 gper1 signaling
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Canonical Pathways (3)
- M5060 Sa fas signaling
- M79 Pid trail pathway
- M197 Pid hiv nef pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence43
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GNAI2 | PRKCE | Q02156 | S | 44 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| GNAI2 | PRKCE | Q02156 | S | 144 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| GNAI2 | PRKCE | Q02156 | S | 302 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | |||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | Cellinker | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | connectomeDB2020 | |||||
| cell_surface | cell_surface | Baccin2019 | |||||
| cell_surface | cell_surface | OmniPath |
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Regulatory Interaction Network (21)
21 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCE | Q02156 | GNAI2 | P04899 | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20043990 |
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Sequence, Structure & Domains
Sequences
Length
355
Mass
40,451
Sequence
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=P04899-1; Sequence=Displayed; Name=2; IsoId=P04899-2; Sequence=VSP_017497; Name=3; IsoId=P04899-3; Sequence=VSP_043473; Name=sGi2; Synonyms=sGalphai2; IsoId=P04899-4; Sequence=VSP_043903; Name=5; IsoId=P04899-5; Sequence=VSP_054789; Name=6; IsoId=P04899-6; Sequence=VSP_054788
Alternative Sequence
1..52; Missing (in isoform 6); 1..39; MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLL -> MEYAGHLPASSAQGTILACTSCT (in isoform 2); 1..39; MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLL -> MR (in isoform 3); 1..39; MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLL -> MTEGVKTLGWTKQKGGCHWGRSE (in isoform 5); 332..355; NVQFVFDAVTDVIIKNNLKDCGLF -> SRKLFRETYLKLSGPDQHPHPSPAPAPPLSSDSVP (in isoform sGi2)
3D Structural Models
Turn
51..53; 209..212; 236..238; 273..275; 285..287; 299..301; 315..317; 329..331
Helix
7..30; 46..48; 213..216; 228..230; 243..255; 258..260; 276..281; 302..310; 332..351
Beta Strand
33..39; 42..44; 186..191; 196..201; 220..227; 231..233; 239..242; 264..270; 296..298; 320..324
3D Structure
Electron microscopy (25)
Domain & Motif Annotations
Domain (FT)
32..355; G-alpha
Region
35..48; G1 motif; 174..182; G2 motif; 197..206; G3 motif; 266..273; G4 motif; 325..330; G5 motif
Protein Families (2)
- G-alpha family
- G(i/o/t/z) subfamily
Sequence Similarities
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Clinical Relevance
Drug Targets
Clinical trial target
Drugs (19)
Antibody
Interaction Protein (3)
ENSG00000078369ENSG00000112559ENSG00000160683
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications43
| PMID | Title | Related sentences |
|---|---|---|
| 25755179 | Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease. | No related sentences available |
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No related sentences available |
| 27487081 | Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation. | No related sentences available |
| 28680152 | Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity. | No related sentences available |
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No related sentences available |
| 31617158 | Proteomic profiling of peritoneal dialysis effluent-derived extracellular vesicles: a longitudinal study. | No related sentences available |
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No related sentences available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No related sentences available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No related sentences available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
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