Protein detail

GNAI2

Guanine nucleotide-binding protein G(i) subunit alpha-2 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)

Entry name
GNAI2
UniProt ID
P04899
EVMP confidence score
0.75
Supporting publications (n)
45
Transmembrane count
Protein classification
Human disease related genesPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Guanine nucleotide-binding protein G(i) subunit alpha-2 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Protein Class (2)
Human disease related genesPredicted intracellular proteins
Protein Function (3)
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Predicted intracellular proteins
  • Human disease related genes:Cardiovascular diseases:Cardiac diseases
Ensembl
ENSG00000114353
Entrez Gene Symbol
GNAI2
Gene Synonym (2)
GIPGNAI2B
Gene Description
G protein subunit alpha i2
Chromosome
3
Position
50226292-50259362
Supporting publications (n)
45
EVMP confidence score
0.75
Fluorescence & Localization3
GNAI2 fluorescence
Cell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway8
Protein Function (3)
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Predicted intracellular proteins
  • Human disease related genes:Cardiovascular diseases:Cardiac diseases
Cellular Component (14)
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Molecular Function (6)
Biological Process (3)
KEGG (43)
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Reactome (27)
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Canonical Pathways (3)
  • M5060 Sa fas signaling
  • M79 Pid trail pathway
  • M197 Pid hiv nef pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence43

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
GNAI2PRKCEQ02156S44phosphorylationPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
GNAI2PRKCEQ02156S144phosphorylationPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
GNAI2PRKCEQ02156S302phosphorylationPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling (19)

19 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorBaccin2019NoYesNoNoNo
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_surface_ligandcell_surface_ligandconnectomeDB2020YesNoNoNoNo
cell_surface_ligandcell_surface_ligandBaccin2019YesNoNoNoNo
cell_surface_ligandcell_surface_ligandOmniPathYesNoNoNoNo
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Regulatory Interaction Network (21)

21 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
GNAI2P04899ADCY5O95622YesNoYesKEGG-MEDICUSSIGNORSignaLink3WangTCRcuration_SignaLink3SIGNOR:8119955SignaLink3:7935349SignaLink3:23109003SignaLink3:11376933SignaLink3:15539636SignaLink3:16460834
GNAI2P04899ADCY6O43306YesNoYesKEGG-MEDICUSSIGNORSignaLink3WangTCRcuration_SignaLink3SIGNOR:8119955SignaLink3:7935349SignaLink3:23109003SignaLink3:11376933SignaLink3:15539636SignaLink3:16460834
CCR5P51681GNAI2P04899YesYesNoKEGG-MEDICUSHPRDSignaLink3WangTCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003HPRD:15251452SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
CXCR4P61073GNAI2P04899YesYesNoKEGG-MEDICUSSIGNORSignaLink3WangTCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SIGNOR:33073183SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
ARBK1P25098GNAI2P04899YesNoNoSignaLink3TCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
ARBK2P35626GNAI2P04899YesNoNoSignaLink3TCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
GRK4P32298GNAI2P04899YesNoNoSignaLink3TCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
GRK5P34947GNAI2P04899YesNoNoSignaLink3TCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
GRK6P43250GNAI2P04899YesNoNoSignaLink3TCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
ARRB1P49407GNAI2P04899YesNoYesSignaLink3TCRcuration_SignaLink3SignaLink3:16183910SignaLink3:10508237SignaLink3:18538863SignaLink3:23109003SignaLink3:15337520SignaLink3:17084806SignaLink3:10644702
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Sequence, Structure & Domains13

Sequences

Length
355
Mass
40,451
Sequence
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=P04899-1; Sequence=Displayed; Name=2; IsoId=P04899-2; Sequence=VSP_017497; Name=3; IsoId=P04899-3; Sequence=VSP_043473; Name=sGi2; Synonyms=sGalphai2; IsoId=P04899-4; Sequence=VSP_043903; Name=5; IsoId=P04899-5; Sequence=VSP_054789; Name=6; IsoId=P04899-6; Sequence=VSP_054788
Alternative Sequence
1..52; Missing (in isoform 6); 1..39; MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLL -> MEYAGHLPASSAQGTILACTSCT (in isoform 2); 1..39; MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLL -> MR (in isoform 3); 1..39; MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLL -> MTEGVKTLGWTKQKGGCHWGRSE (in isoform 5); 332..355; NVQFVFDAVTDVIIKNNLKDCGLF -> SRKLFRETYLKLSGPDQHPHPSPAPAPPLSSDSVP (in isoform sGi2)

3D Structural Models

Turn
51..53; 209..212; 236..238; 273..275; 285..287; 299..301; 315..317; 329..331
Helix
7..30; 46..48; 213..216; 228..230; 243..255; 258..260; 276..281; 302..310; 332..351
Beta Strand
33..39; 42..44; 186..191; 196..201; 220..227; 231..233; 239..242; 264..270; 296..298; 320..324
3D Structure
Electron microscopy (25)

Domain & Motif Annotations

Domain (FT)
32..355; G-alpha
Region
35..48; G1 motif; 174..182; G2 motif; 197..206; G3 motif; 266..273; G4 motif; 325..330; G5 motif
Protein Families (2)
  • G-alpha family
  • G(i/o/t/z) subfamily
Sequence Similarities
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Clinical Relevance6
Drug Targets
Clinical trial target
Drugs (19)
VENADAPARIBAG14361SARUPARIBDUAL VEGFR/PARP INHIBITOR 14BPAMIPARIBCOMPOUND 5 [TOMASSI ET AL., 2020]NIRAPARIBLERZEPARIBAZ1366PJ34ME0328AZD9574COMPOUND 10B [PMID: 26222319]OLAPARIBCOMPOUND 9 [LIN ET AL., 2023]RUCAPARIBCICLOPIROXMC2050TALAZOPARIB
Antibody
HPA007704
Interaction Protein (3)
ENSG00000078369ENSG00000112559ENSG00000160683
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications43
PMIDTitleAbstract
32916986Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.No abstract available
33309826Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts.No abstract available
33592500A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.No abstract available
34064677Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.No abstract available
34473505Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.No abstract available
34576246Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.No abstract available
34599510Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease.In particular, an increase in the amount of S100A8 and S100A9 carried by exosomes of severe pancreatitis suggests that the mechanism of action of exosomes is mediated by the effect of these proteins on NADPH oxidase.
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No abstract available
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No abstract available
36497184Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.No abstract available
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