Protein detail
AT1B1
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
Protein symbol AT1B1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
Protein Class
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Primary Active Transporters
- Predicted intracellular proteins
Transmembrane
35..62; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ATP1B
Gene Description
ATPase Na+/K+ transporting subunit beta 1
Chromosome
1
Position
169105697-169310992
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Transporters:Primary Active Transporters
- Predicted intracellular proteins
Cellular Component
- GO:0005886 plasma membrane
- GO:0005890 sodium:potassium-exchanging ATPase complex
- GO:0014704 intercalated disc
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030315 T-tubule
- GO:0031090 organelle membrane
- GO:0036126 sperm flagellum
- GO:0042383 sarcolemma
- GO:0070062 extracellular exosome
- GO:1903561 extracellular vesicle
Molecular Function
- GO:0001671 ATPase activator activity
- GO:0005391 P-type sodium:potassium-exchanging transporter activity
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0023026 MHC class II protein complex binding
- GO:0030674 protein-macromolecule adaptor activity
- GO:0046982 protein heterodimerization activity
- GO:0051117 ATPase binding
Biological Process
KEGG
- hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04260 Cardiac muscle contraction
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04918 Thyroid hormone synthesis
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04960 Aldosterone-regulated sodium reabsorption
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04964 Proximal tubule bicarbonate reclamation
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa04973 Carbohydrate digestion and absorption
- KEGG:hsa04974 Protein digestion and absorption
- KEGG:hsa04976 Bile secretion
- KEGG:hsa04978 Mineral absorption
Reactome
- R-hsa-210991 basigin interactions
- R-hsa-5576891 cardiac conduction
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-397014 muscle contraction
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9679506 sars cov infections
- R-hsa-382551 transport of small molecules
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| sodium_potassium_atpase | transporter | HGNC | No | Yes | No | Yes | No |
| transporter | transporter | HGNC | No | Yes | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| WFS1 | O76024 | AT1B1 | P05026 | Yes | Yes | No | SIGNOR | SIGNOR:17947299 |
| RN183 | Q96D59 | AT1B1 | P05026 | Yes | No | Yes | SIGNOR | SIGNOR:31732153 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains
Sequences
Length
303
Mass
35,061
Sequence
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05026-1; Sequence=Displayed; Name=2; IsoId=P05026-2; Sequence=VSP_000349
Alternative Sequence
300..303; EVKS -> KF (in isoform 2)
3D Structural Models
Turn
11..14; 19..22; 70..72; 95..98; 120..122; 165..172
Helix
29..59; 99..108; 109..112; 114..116; 153..159; 218..223; 240..242; 247..250
Beta Strand
23..25; 63..65; 76..81; 84..90; 139..145; 160..163; 175..180; 194..200; 208..217; 227..239; 259..263; 268..270; 272..278; 292..301
3D Structure
Electron microscopy (9)
Domain & Motif Annotations
Domain (CC)
The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Region
191..303; immunoglobulin-like
Protein Families
X(+)/potassium ATPases subunit beta family
Sequence Similarities
Belongs to the X(+)/potassium ATPases subunit beta family.
Clinical Relevance
Drugs
Antibody
Interaction Protein
ENSG00000144891ENSG00000163399
Interaction Count
2
Interaction Dataset
intact_biogridintact_biogrid_opencell