Protein detail
ITB2
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
Entry name ITB2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
Protein Class
CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- CD markers
- Predicted intracellular proteins
Transmembrane
701..723; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD18LFA-1MAC-1MFI7
Gene Description
Integrin subunit beta 2
Chromosome
21
Position
44885953-44931989
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificNeutrophilsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- CD markers
- Predicted intracellular proteins
Cellular Component
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0008305 integrin complex
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0034687 integrin alphaL-beta2 complex
- GO:0034688 integrin alphaM-beta2 complex
- GO:0034689 integrin alphaX-beta2 complex
- GO:0035579 specific granule membrane
- GO:0043235 receptor complex
- GO:0044853 plasma membrane raft
- GO:0070062 extracellular exosome
- GO:0070821 tertiary granule membrane
- GO:0101003 ficolin-1-rich granule membrane
- GO:1903561 extracellular vesicle
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0001851 complement component C3b binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0030369 ICAM-3 receptor activity
- GO:0031072 heat shock protein binding
- GO:0038024 cargo receptor activity
- GO:0046872 metal ion binding
- GO:0050839 cell adhesion molecule binding
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04145 Phagosome
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04610 Complement and coagulation cascades
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05133 Pertussis
- KEGG:hsa05134 Legionellosis
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05144 Malaria
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05323 Rheumatoid arthritis
- KEGG:hsa05416 Viral myocarditis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-6798695 neutrophil degranulation
- R-hsa-449147 signaling by interleukins
- R-hsa-168898 toll like receptor cascades
Canonical Pathways
M67 Pid arf6 trafficking pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
26 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGB2 | PRKCD | Q05655 | S | 745 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11700305KEA:11700305ProtMapper:11700305phosphoELM:11700305 |
| ITGB2 | PRKCD | Q05655 | T | 758 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:18550856ProtMapper:15212693SIGNOR:11700305ProtMapper:18550856KEA:12682249KEA:11700305ProtMapper:11700305phosphoELM:11700305 |
| ITGB2 | PRKCD | Q05655 | S | 756 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:11700305 |
| ITGB2 | PRKCD | Q05655 | T | 760 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ITGB2 | LCK | P06239 | Y | 735 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| ITGB2 | PRKCH | C0HM02 | S | 745 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:11700305 |
| ITGB2 | PRKCH | C0HM02 | T | 758 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:12682249KEA:11700305 |
| ITGB2 | PRKCG | P05129 | S | 756 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ITGB2 | PRKCG | P05129 | S | 745 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ITGB2 | PRKCG | P05129 | T | 758 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
70 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| integrin | receptor | Integrins | No | Yes | No | Yes | No |
| integrin | receptor | UniProt_keyword | No | Yes | No | Yes | No |
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Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCB | P05771 | ITB2 | P05107 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11700305HPRD:11700305PhosphoSite:23001012KEA:12682249KEA:11700305ProtMapper:11700305phosphoELM:11700305 |
| SRC | P12931 | ITB2 | P05107 | Yes | Yes | Yes | WangSIGNOR | SIGNOR:25624455 |
| JAK2 | O60674 | ITB2 | P05107 | Yes | Yes | No | SIGNOR | SIGNOR:25624455 |
| ITBP1 | O14713 | ITB2 | P05107 | Yes | No | Yes | SIGNOR | SIGNOR:19118207 |
| KPCA | P17252 | ITB2 | P05107 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperAdhesome | Adhesome:12682249SIGNOR:11700305HPRD:11700305KEA:12682249KEA:11700305ProtMapper:11700305phosphoELM:11700305KEA:17570479Adhesome:11700305 |
| KPCD | Q05655 | ITB2 | P05107 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite | PhosphoSite:29903913SIGNOR:18550856PhosphoSite:16301335ProtMapper:15212693PhosphoSite:23823319SIGNOR:11700305ProtMapper:18550856PhosphoSite:12682249HPRD:11700305PhosphoSite:17107954KEA:12682249KEA:11700305PhosphoSite:18550856ProtMapper:11700305phosphoELM:11700305PhosphoSite:11700305PhosphoSite:25278023 |
| KPCL | P24723 | ITB2 | P05107 | Yes | No | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:11700305HPRD:11700305KEA:12682249KEA:11700305ProtMapper:11700305phosphoELM:11700305 |
| PKHUO | C0HM02 | ITB2 | P05107 | Yes | No | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:11700305HPRD:11700305KEA:12682249KEA:11700305ProtMapper:11700305phosphoELM:11700305 |
| TLN1 | Q9Y490 | ITB2 | P05107 | Yes | Yes | No | HPRDWangSIGNORAdhesome | HPRD:2150484SIGNOR:19118207Adhesome:2150484Adhesome:12606711HPRD:12606711 |
| DOK1 | Q99704 | ITB2 | P05107 | Yes | No | Yes | InnateDBHPRDSIGNOR | HPRD:12606711SIGNOR:19118207InnateDB:12606711 |
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Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AD/b2 integrin | ITGADITGB2 | P05107Q13349 | 1:1 | CellChatDBCellPhoneDBICELLNETSIGNORComplexPortal | intact:EBI-2568401SIGNOR:SIGNOR-C172CellPhoneDB:integrin_aDb2_complex | 169432051229704214755292877771419693543 |
| ITGB2-RACK1 complex | ITGB2RACK1 | P05107P63244 | 0:0 | CORUM | CORUM:7013 | 9442085 |
| ITGB2 | P05107 | 2 | PDB | PDB:2p28PDB:1yuk |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 22655043 |
Sequence, Structure & Domains
Sequences
Length
769
Mass
84,791
Sequence
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
3D Structural Models
Turn
177..179; 552..554; 580..582; 609..612; 633..635
Helix
33..37; 49..51; 58..61; 65..70; 75..77; 137..139; 140..146; 150..160; 184..188; 214..222; 236..245; 247..250; 272..276; 294..297; 304..313; 324..326; 327..331; 333..336; 352..364; 451..453; 458..461; 490..495; 505..508; 590..592; 621..623; 626..632; 702..734
Beta Strand
44..46; 54..56; 62..64; 84..88; 91..94; 96..99; 101..107; 109..111; 113..119; 121..123; 127..134; 161..163; 165..171; 194..196; 203..212; 230..234; 254..265; 289..292; 316..322; 337..339; 341..344; 347..349; 365..371; 378..385; 387..389; 391..402; 409..419; 424..430; 437..443; 455..457; 462..466; 469..472; 476..478; 483..487; 498..500; 509..513; 516..519; 528..531; 536..539; 544..550; 555..558; 561..564; 568..570; 577..579; 593..597; 600..603; 616..618; 639..641; 643..647; 650..652; 659..661; 662..665; 667..672; 674..678; 680..683; 685..689; 754..762
3D Structure
Electron microscopy (2); NMR spectroscopy (3); X-ray crystallography (18)
Domain & Motif Annotations
Motif
397..399; Cell attachment site
Domain (CC)
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
Domain (FT)
24..74; PSI; 124..363; VWFA; 449..482; I-EGF 1; 483..535; I-EGF 2; 536..574; I-EGF 3; 575..613; I-EGF 4
Protein Families
Integrin beta chain family
Sequence Similarities
Belongs to the integrin beta chain family.
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Biomarker
Discontinued in Phase 1; Phase 1/2; Discontinued in Phase 2
Drug Targets
Clinical trial targetSuccessful targetLiterature-reported target
Drugs
PANCREATIC PROTEOLYTIC ENZYMESPENTOXIFYLLINESODIUM BUTYRATEMETHYLPREDNISOLONECYCLOOXYGENASE INHIBITORAME-133VDEHYDRATED ALCOHOLLIFITEGRASTLYMPHOKINE-ACTIVATED KILLER CELLSNULLERLIZUMABMONOMETHYL FUMARATEH2O2BUTEINVISILIZUMABSODIUM CHLORIDECYCLOSPORINEPHORBOL 12-MYRISTATE 13-ACETATEHYDROGEN PEROXIDEENZYME INHIBITORPREDNISONECYCLOPHOSPHAMIDE ANHYDROUSCOLCHICINETHALIDOMIDEMLNM-2201ANTIBIOTICINDOMETHACINRECOMBINANT C5ATRETINOINRECOMBINANT LYMPHOKINEROVELIZUMABRECOMBINANT HUMAN THROMBOPOIETINMLN-01RECOMBINANT RANTESTETRADECANOYLPHORBOL ACETATERECOMBINANT FAS LIGANDEFALIZUMAB
Interaction Protein
ENSG00000010017ENSG00000146648
Interaction Count
2
Interaction Dataset
intact_biogrid