Protein detail
PPB1
Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)
Entry name PPB1 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)
Protein Class (5)
Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (4)
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Transmembrane
513..529; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
PALPPLAP
Gene Description
Alkaline phosphatase, placental
Chromosome
2
Position
232378724-232382889
Supporting publications (n)
3
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Secretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway
Protein Function (4)
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (4)
Reactome (4)
Canonical Pathways
M239 Pid a6b1 a6b4 integrin pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence15
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | Yes | ||||
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ALPPCOPS6CUL1CUL2CUL3CUL4ACUL4BCUL5DCUN1D1NEDD8RBX1SUMO3UBCUBE2MUBXN7 | O94888P05187P0CG48P55854P61081P62877Q13616Q13617Q13618Q13619Q13620Q15843Q7L5N1Q93034Q96GG9 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5033 | ||
| GPALPP1PGM5PPIL1 | Q15124Q8IXQ4Q9Y3C6 | 0:0:0 | hu.MAP2 | |||
| ARL6IP4GPALPP1 | Q66PJ3Q8IXQ4 | 0:0 | hu.MAP | |||
| GPALPP1PPIL1 | Q8IXQ4Q9Y3C6 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
535
Mass
57,954
Sequence
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
3D Structural Models
Turn
180..182; 304..306; 369..371
Helix
26..29; 31..47; 68..81; 93..95; 114..123; 143..145; 154..160; 176..179; 193..195; 198..202; 208..214; 226..229; 243..245; 255..261; 272..279; 299..301; 310..321; 337..342; 346..366; 433..436; 468..470; 479..487; 491..493
Beta Strand
56..63; 97..103; 132..134; 164..172; 219..224; 249..251; 266..269; 285..290; 292..295; 328..334; 372..379; 381..386; 411..418; 445..447; 459..465; 473..476
3D Structure
X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
434..446; Polar residues
Region
425..449; Disordered
Protein Families
Alkaline phosphatase family
Sequence Similarities
Belongs to the alkaline phosphatase family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs (10)
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 35212939 | Novel Exosome Biomarker Candidates for Alzheimer's Disease Unravelled Through Mass Spectrometry Analysis. | Among them are AACT and C4BPα, two Aβ-binding proteins, whose exosome levels were further validated in individuals from independent cohorts using antibody-based approaches. |
| 40748658 | Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures. | No related sentences available |