Protein detail
ICAM1
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Protein symbol ICAM1 | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count 1 | Protein classification Cancer-related genesCandidate cardiovascular disease genesCD markersFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesCD markersFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
481..503; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BB2CD54
Gene Description
Intercellular adhesion molecule 1
Chromosome
19
Position
10271093-10286615
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0001772 immunological synapse
- GO:0005615 extracellular space
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0045121 membrane raft
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
KEGG
- hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa05143 African trypanosomiasis
- KEGG:hsa05144 Malaria
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05164 Influenza A
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05323 Rheumatoid arthritis
- KEGG:hsa05416 Viral myocarditis
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1474244 extracellular matrix organization
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-216083 integrin cell surface interactions
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-449147 signaling by interleukins
Canonical Pathways
- M68 Pid rhoa reg pathway
- M281 Pid fak pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ICAM1 | SRC | P12931 | Y | 512 | phosphorylation | RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22846676ProtMapper:25097454ProtMapper:21474822 |
| ICAM1 | TNF | P01375 | Y | 512 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22846676ProtMapper:21474822 |
Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | LOCATE | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MARH9 | Q86YJ5 | ICAM1 | P05362 | Yes | No | Yes | SIGNOR | SIGNOR:17174307 |
| ITAL | P20701 | ICAM1 | P05362 | Yes | Yes | No | HPMRWangCellPhoneDBSIGNORHINTBioGRIDIntActDIPSPIKE_LCLit-BM-17 | HINT:11279101SIGNOR:23994464Lit-BM-17:11279101BioGRID:12526797HINT:12208882IntAct:12526797HPMR:16354667IntAct:16595626DIP:16595626Lit-BM-17:12526797HPMR:14507735BioGRID:11786177HINT:12526797HINT:29997244Lit-BM-17:11786177HINT:16595626HINT:11786177HINT:22956999SPIKE_LC:16189514 |
| ITAM | P11215 | ICAM1 | P05362 | Yes | Yes | No | HPRDWangSIGNOR | HPRD:11073102SIGNOR:23994464HPRD:9488691 |
| ICAM1 | P05362 | ITAX | P20702 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020WangLRdbSTRING_talklrHPMR_talklr | SIGNOR:7679388LRdb:4062888connectomeDB2020:4062888 |
| COMPLEX:P05107_P20701 | ICAM1 | P05362 | Yes | Yes | No | CellPhoneDBSIGNOR | SIGNOR:12808052 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ICAM1 | P05362 | 2 | PDB | PDB:1ic1PDB:1p53 | ||
| ICAM1NAT1 | P05362P18440 | 0:0 | hu.MAP | |||
| IRF7TICAM1TNFAIP3 | P21580Q8IUC6Q92985 | 1:1:1 | CompleatCFinder | Compleat:HC6483 | ||
| IRF3TICAM1 | Q14653Q8IUC6 | 1:1 | PDB | PDB:5jel | ||
| TICAM1 | Q8IUC6 | 4 | PDB | PDB:8rlmPDB:9dk8PDB:4c0mPDB:4bsx |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
532
Mass
57,825
Sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
3D Structural Models
Turn
164..166; 434..436
Helix
143..145; 177..179; 193..195; 245..247; 280..282; 362..364; 400..402; 449..451
Beta Strand
29..39; 42..50; 52..54; 56..61; 66..69; 71..84; 91..95; 97..99; 100..104; 106..111; 114..118; 123..125; 129..138; 146..152; 155..161; 167..174; 183..191; 199..203; 210..212; 220..222; 225..228; 231..241; 249..254; 262..265; 267..278; 284..294; 297..308; 314..318; 320..323; 327..333; 338..344; 346..348; 351..354; 357..359; 367..376; 378..397; 405..410; 422..425; 428..433; 453..461; 464..475
3D Structure
Electron microscopy (5); X-ray crystallography (9)
Domain & Motif Annotations
Motif
152..154; Cell attachment site; atypical
Domain (FT)
41..103; Ig-like C2-type 1; 128..193; Ig-like C2-type 2; 230..297; Ig-like C2-type 3; 325..378; Ig-like C2-type 4; 412..464; Ig-like C2-type 5
Protein Families
- Immunoglobulin superfamily
- ICAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Related Diseases
Biomarker
Phase 3; Phase 2; Terminated; Phase 1; Approved
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000005844ENSG00000127824
Interaction Count
2
Interaction Dataset
intact_biogridbiogrid_bioplex