Protein detail
ICAM1
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Entry name ICAM1 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 9 | Transmembrane count 1 | Protein classification Cancer-related genesCandidate cardiovascular disease genesCD markersFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Protein Class (9)
Cancer-related genesCandidate cardiovascular disease genesCD markersFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (7)
- Predicted intracellular proteins
- CD markers
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
481..503; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
BB2CD54
Gene Description
Intercellular adhesion molecule 1
Chromosome
19
Position
10271093-10286615
Supporting publications (n)
9
EVMP confidence score
0.63
Fluorescence & Localization1
Function & Pathway8
Protein Function (7)
- Predicted intracellular proteins
- CD markers
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component (10)
- GO:0001772 immunological synapse
- GO:0005615 extracellular space
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0045121 membrane raft
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
Molecular Function (5)
Biological Process (3)
KEGG (19)
- hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa05143 African trypanosomiasis
- KEGG:hsa05144 Malaria
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Reactome (10)
- R-hsa-1280218 adaptive immune system
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1474244 extracellular matrix organization
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-216083 integrin cell surface interactions
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-449147 signaling by interleukins
Canonical Pathways (2)
- M68 Pid rhoa reg pathway
- M281 Pid fak pathway
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence64
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ICAM1 | SRC | P12931 | Y | 512 | phosphorylation | RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22846676ProtMapper:25097454ProtMapper:21474822 |
| ICAM1 | TNF | P01375 | Y | 512 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22846676ProtMapper:21474822 |
Ligand-Receptor Signaling (51)
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | EMBRACE | Yes | No | No | Yes | No |
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | CellTalkDB | Yes | No | No | Yes | No |
| ligand | ligand | Ramilowski2015 | Yes | No | No | Yes | No |
| ligand | ligand | LRdb | Yes | No | No | Yes | No |
| cell_adhesion | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MARH9 | Q86YJ5 | ICAM1 | P05362 | Yes | No | Yes | SIGNOR | SIGNOR:17174307 |
| ITAL | P20701 | ICAM1 | P05362 | Yes | Yes | No | HPMRWangCellPhoneDBSIGNORHINTBioGRIDIntActDIPSPIKE_LCLit-BM-17 | HINT:11279101SIGNOR:23994464Lit-BM-17:11279101BioGRID:12526797HINT:12208882IntAct:12526797HPMR:16354667IntAct:16595626DIP:16595626Lit-BM-17:12526797HPMR:14507735BioGRID:11786177HINT:12526797HINT:29997244Lit-BM-17:11786177HINT:16595626HINT:11786177HINT:22956999SPIKE_LC:16189514 |
| ITAM | P11215 | ICAM1 | P05362 | Yes | Yes | No | HPRDWangSIGNOR | HPRD:11073102SIGNOR:23994464HPRD:9488691 |
| ICAM1 | P05362 | ITAX | P20702 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020WangLRdbSTRING_talklrHPMR_talklr | SIGNOR:7679388LRdb:4062888connectomeDB2020:4062888 |
| COMPLEX:P05107_P20701 | ICAM1 | P05362 | Yes | Yes | No | CellPhoneDBSIGNOR | SIGNOR:12808052 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ICAM1 | P05362 | 2 | PDB | PDB:1ic1PDB:1p53 | ||
| ICAM1NAT1 | P05362P18440 | 0:0 | hu.MAP | |||
| IRF7TICAM1TNFAIP3 | P21580Q8IUC6Q92985 | 1:1:1 | CompleatCFinder | Compleat:HC6483 | ||
| IRF3TICAM1 | Q14653Q8IUC6 | 1:1 | PDB | PDB:5jel | ||
| TICAM1 | Q8IUC6 | 4 | PDB | PDB:8rlmPDB:9dk8PDB:4c0mPDB:4bsx |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains11
Sequences
Length
532
Mass
57,825
Sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
3D Structural Models
Turn
164..166; 434..436
Helix
143..145; 177..179; 193..195; 245..247; 280..282; 362..364; 400..402; 449..451
Beta Strand
29..39; 42..50; 52..54; 56..61; 66..69; 71..84; 91..95; 97..99; 100..104; 106..111; 114..118; 123..125; 129..138; 146..152; 155..161; 167..174; 183..191; 199..203; 210..212; 220..222; 225..228; 231..241; 249..254; 262..265; 267..278; 284..294; 297..308; 314..318; 320..323; 327..333; 338..344; 346..348; 351..354; 357..359; 367..376; 378..397; 405..410; 422..425; 428..433; 453..461; 464..475
3D Structure
Electron microscopy (5); X-ray crystallography (9)
Domain & Motif Annotations
Motif
152..154; Cell attachment site; atypical
Domain (FT)
41..103; Ig-like C2-type 1; 128..193; Ig-like C2-type 2; 230..297; Ig-like C2-type 3; 325..378; Ig-like C2-type 4; 412..464; Ig-like C2-type 5
Protein Families (2)
- Immunoglobulin superfamily
- ICAM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Clinical Relevance9
Disease Involvement (2)
Cancer-related genesFDA approved drug targets
Related Diseases (11)
Biomarker
Phase 3; Phase 2; Terminated; Phase 1; Approved
Drug Targets
FDA approved drug targets
Interaction Protein (2)
ENSG00000005844ENSG00000127824
Interaction Count
2
Interaction Dataset (2)
intact_biogridbiogrid_bioplex
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 28369848 | End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39949490 | CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |