Protein detail

CD5

T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)

Protein symbol CD5	UniProt ID P06127	EVMP score 0.25
Frequency 4	Transmembrane count 1	Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)

Protein Class

CD markersPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins

Transmembrane

373..402; Helical

Transmembrane Count

Ensembl

ENSG00000110448

Entrez Gene Symbol

CD5

Gene Synonym

LEU1T1

Gene Description

CD5 molecule

Chromosome

Position

61102489-61127852

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04640 Hematopoietic cell lineage

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

22 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CD5	CSNK2A1	P68400	S	482	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:9834084 KEA:9834084 SIGNOR:9834084 ProtMapper:9834084 HPRD:9834084
CD5	CSNK2A1	P68400	S	483	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:9834084 KEA:9834084 SIGNOR:9834084 ProtMapper:9834084 HPRD:9834084
CD5	CSNK2A1	P68400	S	485	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:9834084 KEA:9834084 SIGNOR:9834084 ProtMapper:9834084 HPRD:9834084
CD5	LCK	P06239	Y	453	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:11298344 phosphoELM:11298344 HPRD:15144186 KEA:15659558 KEA:11298344 KEA:15144186 SIGNOR:11298344 HPRD:11298344 KEA:12522270
CD5	LCK	P06239	Y	487	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:11298344 phosphoELM:11298344 SIGNOR:11298344 KEA:11298344 HPRD:11298344
CD5	PRKCA	P17252	T	434	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317 phosphoELM:11123317
CD5	PRKCA	P17252	T	436	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317 phosphoELM:11123317
CD5	PRKCG	P05129	T	436	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317
CD5	PRKCG	P05129	T	434	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317
CD5	PRKCB	P05771	T	434	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317

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Ligand-Receptor Signaling

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
scavenger_receptor_cysteine_rich	receptor	OmniPath	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LCK	P06239	CD5	P06127	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEADIPPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	ProtMapper:11298344 ProtMapper:15144186 phosphoELM:11298344 DIP:7513045 HPRD:15144186 HPRD:7513045 KEA:11298344 KEA:15144186 KEA:15659558 SIGNOR:11298344 HPRD:11298344 HPRD-phos:11298344 HPRD-phos:15144186 KEA:12522270
CSK21	P68400	CD5	P06127	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos	PhosphoSite:9834084 SIGNOR:9834084 KEA:9834084 phosphoELM:9834084 HPRD:9834084 ProtMapper:9834084 HPRD-phos:9834084
KPCB	P05771	CD5	P06127	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317 HPRD:11123317
KPCG	P05129	CD5	P06127	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper	SIGNOR:11123317 KEA:11123317 ProtMapper:11123317 HPRD:11123317
FYN	P06241	CD5	P06127	Yes	Yes	No	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper	PhosphoSite:26363459 ProtMapper:11298344 ProtMapper:15144186 HPRD:15144186 KEA:15659558 KEA:11298344 KEA:15144186 SIGNOR:11298344 PhosphoSite:11751967 HPRD:11298344 PhosphoSite:11298344 HPRD-phos:11298344 HPRD-phos:15144186 KEA:12522270
KPCA	P17252	CD5	P06127	Yes	Yes	No	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:11123317 KEA:11123317 HPRD:11123317 SIGNOR:11123317 phosphoELM:11123317

Protein Complex Composition

14 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster458	MSANTD1 SCD SCD5	O00767 Q6ZTZ1 Q86SK9	1:1:1	Compleat	Compleat:HC241	22036573
	CCT4 CCT8 HGH1 MLST8 PDCD5 PDCL PDCL3 TXNDC9	O14530 O14737 P50990 P50991 Q13371 Q9BTY7 Q9BVC4 Q9H2J4	0:0:0:0:0:0:0:0	hu.MAP
	HGH1 PDCD5 PDCL3 TXNDC9	O14530 O14737 Q9BTY7 Q9H2J4	0:0:0:0	hu.MAP
	HGH1 PDCD5 PDCL3 SEC31B TXNDC9	O14530 O14737 Q9BTY7 Q9H2J4 Q9NQW1	0:0:0:0:0	hu.MAP
	IMPA1 MTIF2 PDCD5 PLBD2 PPA2	O14737 P29218 P46199 Q8NHP8 Q9H2U2	0:0:0:0:0	hu.MAP2
	HGH1 MLST8 PDCD5	O14737 Q9BTY7 Q9BVC4	0:0:0	hu.MAP
	C2CD5 CABLES1 CABLES2 FIBP TMEM94	O43427 Q12767 Q86YS7 Q8TDN4 Q9BTV7	0:0:0:0:0	hu.MAPhu.MAP2
	C2CD5 CABLES1 CABLES2 FIBP	O43427 Q86YS7 Q8TDN4 Q9BTV7	0:0:0:0	hu.MAP2
	C2CD5 ESRRA IPO13 PWP2 RRP9 WDR36	O43818 O94829 P11474 Q15269 Q86YS7 Q8NI36	0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_504
	CD5L IGHM JCHAIN	O43866 P01591 P01871	1:1:10	PDB	PDB:8r84PDB:8wysPDB:8wyrPDB:8r83

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	32230970

Sequence, Structure & Domains

Sequences

Length

495

Mass

54,578

Sequence

MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL

3D Structural Models

Turn

101..103

Helix

75..77; 78..83; 310..318; 347..349

Beta Strand

35..37; 39..42; 45..52; 55..58; 86..88; 90..94; 104..110; 117..119; 122..124; 126..132; 275..280; 286..295; 298..301; 323..331; 339..341; 344..346; 354..356; 362..367

3D Structure

NMR spectroscopy (2); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

142..155; Pro residues; 475..484; Polar residues

Domain (FT)

35..133; SRCR 1; 159..268; SRCR 2; 276..368; SRCR 3

Region

136..155; Disordered; 436..460; Disordered; 473..495; Disordered

Clinical Relevance

Drugs

INOSITOL IONOMYCIN DIFFERENTIATION INDUCER TELIMOMAB ARITOX RECOMBINANT INTERLEUKIN DACTINOMYCIN HEXAMETHYLENE BISACETAMIDE TETRADECANOYLPHORBOL ACETATE ZOLIMOMAB ARITOX GM-CSF

Antibody

CAB015392 CAB020308 HPA043416 HPA060839