Protein detail

CD5

T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)

Protein symbol
CD5
UniProt ID
EVMP score
0.25
Frequency
4
Transmembrane count
1
Protein classification
CD markersPredicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)
Protein Class
CD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function
  • CD markers
  • Predicted intracellular proteins
Transmembrane
373..402; Helical
Transmembrane Count
1
Entrez Gene Symbol
Gene Synonym
LEU1T1
Gene Description
CD5 molecule
Chromosome
11
Position
61102489-61127852
Frequency
4
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
  • CD markers
  • Predicted intracellular proteins
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence

Enzyme-Mediated Modification

22 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CD5CSNK2A1P68400S482phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperphosphoELM:9834084KEA:9834084SIGNOR:9834084ProtMapper:9834084HPRD:9834084
CD5CSNK2A1P68400S483phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperphosphoELM:9834084KEA:9834084SIGNOR:9834084ProtMapper:9834084HPRD:9834084
CD5CSNK2A1P68400S485phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperphosphoELM:9834084KEA:9834084SIGNOR:9834084ProtMapper:9834084HPRD:9834084
CD5LCKP06239Y453phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:11298344phosphoELM:11298344HPRD:15144186KEA:15659558KEA:11298344KEA:15144186SIGNOR:11298344HPRD:11298344KEA:12522270
CD5LCKP06239Y487phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:11298344phosphoELM:11298344SIGNOR:11298344KEA:11298344HPRD:11298344
CD5PRKCAP17252T434phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317phosphoELM:11123317
CD5PRKCAP17252T436phosphorylationPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317phosphoELM:11123317
CD5PRKCGP05129T436phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317
CD5PRKCGP05129T434phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317
CD5PRKCBP05771T434phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317
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Ligand-Receptor Signaling

42 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_surfacecell_surfaceconnectomeDB2020NoNoNoYesNo
cell_surfacecell_surfaceOmniPathNoNoNoYesNo
receptorreceptortalklrNoYesNoYesNo
receptorreceptorCellinkerNoYesNoYesNo
receptorreceptorconnectomeDB2020NoYesNoYesNo
receptorreceptoriTALKNoYesNoYesNo
receptorreceptorCellCellInteractionsNoYesNoYesNo
receptorreceptorEMBRACENoYesNoYesNo
transmembranetransmembrane_predictedPhobiusNoNoNoYesNo
transmembrane_phobiustransmembrane_predictedAlmen2009NoNoNoYesNo
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Regulatory Interaction Network

6 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
LCKP06239CD5P06127YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEADIPPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosProtMapper:11298344ProtMapper:15144186phosphoELM:11298344DIP:7513045HPRD:15144186HPRD:7513045KEA:11298344KEA:15144186KEA:15659558SIGNOR:11298344HPRD:11298344HPRD-phos:11298344HPRD-phos:15144186KEA:12522270
CSK21P68400CD5P06127YesYesNoHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite:9834084SIGNOR:9834084KEA:9834084phosphoELM:9834084HPRD:9834084ProtMapper:9834084HPRD-phos:9834084
KPCBP05771CD5P06127YesNoNophosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317HPRD:11123317
KPCGP05129CD5P06127YesYesNophosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapperSIGNOR:11123317KEA:11123317ProtMapper:11123317HPRD:11123317
FYNP06241CD5P06127YesYesNoWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapperPhosphoSite:26363459ProtMapper:11298344ProtMapper:15144186HPRD:15144186KEA:15659558KEA:11298344KEA:15144186SIGNOR:11298344PhosphoSite:11751967HPRD:11298344PhosphoSite:11298344HPRD-phos:11298344HPRD-phos:15144186KEA:12522270
KPCAP17252CD5P06127YesYesNoPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapperProtMapper:11123317KEA:11123317HPRD:11123317SIGNOR:11123317phosphoELM:11123317

Protein Complex Composition

14 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CD5P061272PDBPDB:2ott
CD52P313582PDBPDB:6obd
C2CD5TMEM94Q12767Q86YS70:0hu.MAP
SCD5SLC25A23Q86SK9Q9BV350:0hu.MAP
Page 2 of 2Previous

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry132230970
Sequence, Structure & Domains

Sequences

Length
495
Mass
54,578
Sequence
MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL

3D Structural Models

Turn
101..103
Helix
75..77; 78..83; 310..318; 347..349
Beta Strand
35..37; 39..42; 45..52; 55..58; 86..88; 90..94; 104..110; 117..119; 122..124; 126..132; 275..280; 286..295; 298..301; 323..331; 339..341; 344..346; 354..356; 362..367
3D Structure
NMR spectroscopy (2); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
142..155; Pro residues; 475..484; Polar residues
Domain (FT)
35..133; SRCR 1; 159..268; SRCR 2; 276..368; SRCR 3
Region
136..155; Disordered; 436..460; Disordered; 473..495; Disordered
Clinical Relevance