Protein detail
FYN
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Entry name FYN | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Protein Class (3)
EnzymesPlasma proteinsPredicted intracellular proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
MGC45350SLKSYN
Gene Description
FYN proto-oncogene, Src family tyrosine kinase
Chromosome
6
Position
111660332-111873452
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization6
Tissue Specificbone marrowCell SpecificExtravillous trophoblastsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway7
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- Predicted intracellular proteins
Cellular Component (15)
- GO:0005634 nucleus
- GO:0005739 mitochondrion
- GO:0005768 endosome
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0030425 dendrite
- GO:0043204 perikaryon
- GO:0044297 cell body
Page 1 of 2
Molecular Function (20)
- GO:0001664 G protein-coupled receptor binding
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016004 phospholipase activator activity
- GO:0019899 enzyme binding
- GO:0031802 type 5 metabotropic glutamate receptor binding
- GO:0042802 identical protein binding
Page 1 of 2
Biological Process (3)
KEGG (15)
- hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04660 T cell receptor signaling pathway
Page 1 of 2
Reactome (81)
- R-hsa-9032500 activated ntrk2 signals through fyn
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-389357 cd28 dependent pi3k akt signaling
- R-hsa-389359 cd28 dependent vav1 pathway
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
Page 1 of 9
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence178
Enzyme-Mediated Modification (45)
45 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FYN | CASR | P41180 | Y | 420 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:18065418 |
| FYN | PTK2B | Q14289 | Y | 420 | phosphorylation | NCI-PID_ProtMapperProtMapper | |
| FYN | PTPN6 | P29350 | Y | 420 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:8790380 |
| FYN | PTPN13 | Q12923 | Y | 420 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11983165 |
| FYN | HTR6 | P50406 | Y | 420 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:22355260 |
| FYN | SOD3 | P08294 | Y | 420 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25751262 |
| FYN | PTGER4 | P35408 | Y | 420 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21900181 |
| FYN | PRKACB | P22694 | S | 21 | phosphorylation | Reactome_ProtMapperProtMapper | |
| FYN | PRKACG | P22612 | S | 21 | phosphorylation | Reactome_ProtMapperProtMapper | |
| FYN | TYK2 | P29597 | Y | 420 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:27521342 |
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Page 1 of 2Next
Regulatory Interaction Network (113)
113 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FYN | P06241 | DAB1 | O75553 | Yes | Yes | Yes | SIGNORProtMapperCui2007Reactome_ProtMapperWang | SIGNOR:21534960 |
| FYN | P06241 | STK11 | Q15831 | Yes | No | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperREACH_ProtMapper | ProtMapper:32336052ProtMapper:21428801ProtMapper:24586906ProtMapper:20142099SIGNOR:20142099ProtMapper:27416781 |
| FYN | P06241 | CHIO | P52757 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:17560670ProtMapper:17560670SIGNOR:17560670 |
| FYN | P06241 | CLIC5 | Q9NZA1 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:10930415SIGNOR:10930415 |
| FYN | P06241 | IFM3 | Q01628 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperBioGRIDInnateDBSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:25599080BioGRID:23055554InnateDB:24627473PhosphoSite:26354436PhosphoSite:29263263ProtMapper:24627473ProtMapper:30687247SIGNOR:24627473PhosphoSite:23055554 |
| FYN | P06241 | SCN5A | Q14524 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:15831816SIGNOR:15831816ProtMapper:15831816PhosphoSite:34373326 |
| FYN | P06241 | FCG2A | P12318 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperReactome_ProtMapperHPRD-phos | phosphoELM:8756631HPRD:8756631KEA:8756631SIGNOR:8756631ProtMapper:8756631HPRD-phos:8756631 |
| FYN | P06241 | COMPLEX:P0DOX6_P0DOX7_P11912_P40259 | Yes | Yes | No | SIGNOR | SIGNOR:32323266 | |
| FYN | P06241 | MAG | P20916 | Yes | Yes | No | MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosSPIKE_LC | HPRD-phos:7525550SIGNOR:7525550KEA:7525550HPRD:7525550SPIKE_LC:16713569ProtMapper:7525550 |
| FYN | P06241 | AAPK2 | P54646 | Yes | No | Yes | SIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:27626315ProtMapper:27626315PhosphoSite:27626315 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ABL1DLGAP4FYNPIK3R1 | P00519P06241P27986Q9Y2H0 | 1:1:1:1 | CompleatCFinder | Compleat:HC4289 | ||
| FYN | P06241 | 2 | PDB | PDB:1g83PDB:3h0iPDB:4u17PDB:4znxPDB:7a2jPDB:2mrkPDB:7a2mPDB:7a2lPDB:3ua6PDB:1shfPDB:7a2nPDB:7a2k | ||
| FYNPIK3R1 | P06241P27986 | 1:1 | PDB | PDB:1a0nPDB:1azg |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 30865381 |
Sequence, Structure & Domains13
Sequences
Length
537
Mass
60,762
Sequence
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=B; IsoId=P06241-1; Sequence=Displayed; Name=2; Synonyms=T; IsoId=P06241-2; Sequence=VSP_024110; Name=3; IsoId=P06241-3; Sequence=VSP_024108
Alternative Sequence
233..287; Missing (in isoform 3); 234..287; RAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWM -> KADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWL (in isoform 2)
3D Structural Models
Turn
125..127; 165..167; 194..196; 209..211; 291..293; 303..305; 358..360; 400..402; 430..432
Helix
135..137; 141..143; 144..146; 156..163; 224..233; 268..270; 308..318; 350..354; 364..383; 393..395; 435..438; 445..460; 472..481; 496..502; 507..509; 513..521
Beta Strand
87..91; 97..100; 108..113; 115..124; 130..134; 138..140; 147..150; 172..177; 179..181; 185..193; 197..207; 213..216; 219..223; 238..240; 263..265; 271..278; 285..290; 294..299; 329..333; 335..337; 339..343; 355..357; 396..399; 403..406; 416..418
3D Structure
NMR spectroscopy (11); X-ray crystallography (40)
Domain & Motif Annotations
Domain (FT)
82..143; SH3; 149..246; SH2; 271..524; Protein kinase
Region
14..35; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance9
Disease Involvement
Proto-oncogene
Related Diseases (3)
Biomarker
Phase 2; Approved; Phase 1
Drug Targets
Literature-reported target
Drugs (36)
CYC-116AST-4871-AZAKENPAULLONEVANDETANIBZM447439TG100-801CHEMBL:CHEMBL379975DASATINIB ANHYDROUSXL-228PAZOPANIBHM50316BARASERTIBCP-547632NVP-TAE684PD-0166285ENMD-981693ILORASERTIBALDESLEUKINDOVITINIBPP2ADAVOSERTIBKENPAULLONEENTRECTINIBRG-1530JNJ-26483327HESPERADINTAMATINIBENMD-2076PF-562271TOZASERTIBCHEMBL:CHEMBL546797CEDIRANIBCOMPOUND 13 [PMID: 17502136]CENISERTIBRECOMBINANT VASCULAR ENDOTHELIAL GROWTH FACTORBINDARIT
Interaction Protein (21)
ENSG00000005020ENSG00000015285ENSG00000050820ENSG00000065675ENSG00000076641ENSG00000080824ENSG00000082074ENSG00000096384ENSG00000100842ENSG00000105401ENSG00000110395ENSG00000117560ENSG00000120899ENSG00000121774ENSG00000134909ENSG00000142949ENSG00000143537ENSG00000145335ENSG00000169398ENSG00000186868ENSG00000197122
Interaction Count
21
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 34656547 | Plasma exosomal proteomic studies of corneal epithelial injury in diabetic and non-diabetic group. | TEM indicated that the exosomes had a double-concave disc-like appearance, with a size of about 100 nm, and Western blot expressed as CD63 and TSG101. |