Protein detail

S10A6

Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)

Entry name
S10A6
UniProt ID
P06703
EVMP confidence score
0.72
Supporting publications (n)
12
Transmembrane count
Protein classification
Cancer-related genesPlasma proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)
Protein Class (3)
Cancer-related genesPlasma proteinsPredicted intracellular proteins
Protein Function (2)
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted intracellular proteins
Ensembl
ENSG00000197956
Entrez Gene Symbol
S100A6
Gene Synonym (4)
2A9CABPCACYPRA
Gene Description
S100 calcium binding protein A6
Chromosome
1
Position
153534599-153536244
Supporting publications (n)
12
EVMP confidence score
0.72
Fluorescence & Localization2
Tissue SpecificintestineCell SpecificColonocytes
Function & Pathway6
Protein Function (2)
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted intracellular proteins
Cellular Component (11)
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Molecular Function (8)
Biological Process (3)
KEGG
hsa04382 Cornified envelope formation
Mediation Categories
Other mediation
Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ligandligandMatrisomeYesNoYesNoNo
ligandligandOmniPathYesNoYesNoNo
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CACY homodimer complexS100A6P067032CORUMPDBPDB:1k9kCORUM:19829578461

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing137953466
Sequence, Structure & Domains10

Sequences

Length
90
Mass
10,180
Sequence
MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYNEALKG

3D Structural Models

Turn
63..65
Helix
4..20; 31..41; 45..47; 51..62; 70..84; 86..88
Beta Strand
22..24; 28..30; 67..69
3D Structure
NMR spectroscopy (1); X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)
12..47; EF-hand 1; 48..83; EF-hand 2
Protein Families
S-100 family
Sequence Similarities
Belongs to the S-100 family.
Clinical Relevance5
Disease Involvement
Cancer-related genes
Antibody (4)
CAB002601HPA007575CAB040549CAB047354
Interaction Protein (4)
ENSG00000004478ENSG00000116161ENSG00000135679ENSG00000160307
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications12
PMIDTitleAbstract
28590090Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.No abstract available
28986585Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.No abstract available
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No abstract available
33035814Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.No abstract available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No abstract available
34186243A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.No abstract available
37205098Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers.No abstract available
37786918Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.No abstract available
38321535Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.No abstract available
39409015SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy.No abstract available
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