Protein detail

CD2

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Entry name CD2	UniProt ID P06729	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Protein Class (4)

CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Transmembrane

210..235; Helical

Transmembrane Count

Ensembl

ENSG00000116824

Entrez Gene Symbol

CD2

Gene Synonym

SRBC

Gene Description

CD2 molecule

Chromosome

Position

116754430-116769229

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificskin 1Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificT-reg

Function & Pathway7

Protein Function (3)

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component (9)

Molecular Function (5)

Biological Process (3)

KEGG (3)

Reactome (2)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence181

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
slam	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No

Page 1 of 5Next

Protein Complex Composition (130)

130 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
BAF complex	ACTB ACTL6A ARID1A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1	O14497 O96019 P51532 P60709 Q12824 Q6STE5 Q8TAQ2 Q92922 Q92925 Q969G3 Q96GM5	1:1:1:1:1:1:1:1:1:1:1	CompleatComplexPortal	intact:EBI-16363954PDB:5gjkCompleat:HC1635	18809673 11790558 9843504 28408647 9845365 12620226 14755292 10884406 11073988 23644491
BAF complex	ACTL6A ARID1A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCE1	O14497 O96019 P51532 Q12824 Q8TAQ2 Q92922 Q92925 Q969G3 Q96GM5	1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC2496CORUM:555	11780067
BRM-associated complex	ACTL6A ARID1A PRMT5 SMARCA2 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCE1	O14497 O14744 O96019 P51531 Q12824 Q8TAQ2 Q92922 Q92925 Q969G3 Q96GM5	1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC1953CORUM:808	11238380 14559996
Brain-specific SWI/SNF ATP-dependent chromatin remodeling complexARID1B-SMARCA2 variant	ACTB ACTL6B ARID1B SMARCA2 SMARCB1 SMARCC2 SMARCD2 SMARCE1	O94805 P51531 P60709 Q12824 Q8NFD5 Q8TAQ2 Q92925 Q969G3	1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-16365533	18809673 11790558 9843504 28408647 9845365 12620226 28695822 14755292 10884406 11073988 23644491
Brain-specific SWI/SNF ATP-dependent chromatin remodeling complexARID1B-SMARCA4 variant	ACTB ACTL6B ARID1B SMARCA4 SMARCB1 SMARCC2 SMARCD2 SMARCE1	O94805 P51532 P60709 Q12824 Q8NFD5 Q8TAQ2 Q92925 Q969G3	1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-16365596	18809673 11790558 9843504 28408647 9845365 12620226 28695822 14755292 10884406 11073988 23644491
Brain-specific SWI/SNF SMARCA2 variant	ACTB ACTL6B ARID1A SMARCA2 SMARCB1 SMARCC2 SMARCD2 SMARCE1	O14497 O94805 P51531 P60709 Q12824 Q8TAQ2 Q92925 Q969G3	1:1:1:1:1:1:1:1	SIGNORComplexPortal	intact:EBI-16363824SIGNOR:SIGNOR-C485	18809673 11790558 9843504 28408647 9845365 12620226 14755292 10884406 11073988 23644491
Brain-specific SWI/SNF SMARCA4 variant	ACTB ACTL6B ARID1A SMARCA4 SMARCB1 SMARCC2 SMARCD2 SMARCE1	O14497 O94805 P51532 P60709 Q12824 Q8TAQ2 Q92925 Q969G3	1:1:1:1:1:1:1:1	SIGNORComplexPortal	SIGNOR:SIGNOR-C486intact:EBI-16365451	18809673 11790558 9843504 28408647 9845365 12620226 14755292 10884406 11073988 23644491
Brg1-associated complex I	ACTL6A ARID1A PRMT5 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1	O14497 O14744 O96019 P51532 Q12824 Q6STE5 Q8TAQ2 Q92922 Q92925 Q969G3 Q96GM5	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC3016	11238380
Brm-associated complex	ACTL6A ARID1A PRMT5 SMARCA2 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1	O14497 O14744 O96019 P51531 Q12824 Q6STE5 Q8TAQ2 Q92922 Q92925 Q969G3 Q96GM5	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC950	11238380
D1-D2-G-X3 complex	BRCA2 FANCD2 FANCG XRCC3	O15287 O43542 P51587 Q9BXW9	0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C301

Page 1 of 13Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	23161513

Sequence, Structure & Domains10

Sequences

Length

351

Mass

39,448

Sequence

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN

3D Structural Models

Turn

88..90; 139..142

Helix

62..64; 73..75; 99..101

Beta Strand

31..36; 41..43; 52..61; 67..71; 77..80; 84..86; 92..94; 103..111; 116..127; 134..138; 143..147; 155..162; 164..170; 172..175; 180..189; 194..203

3D Structure

NMR spectroscopy (3); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

243..262; Basic and acidic residues; 269..280; Polar residues; 326..338; Pro residues

Domain (FT)

25..128; Ig-like V-type; 129..209; Ig-like C2-type

Region

61..75; CD58 binding region 1; 106..120; CD58 binding region 2; 237..351; Disordered

Clinical Relevance9

Disease Involvement

FDA approved drug targets

Related Diseases (2)

Lymphoma Psoriasis

Biomarker

Phase 2; Discontinued in Phase 2

Drug Targets

FDA approved drug targets

Drugs (9)

ZINC CHLORIDE SIPLIZUMAB [3H]HEMICHOLINIUM-3 OCTREOTIDE ACETATE RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN ALDESLEUKIN ALEFACEPT COBALT HEMICHOLINIUM-3

Antibody (2)

CAB002430 HPA003883

Interaction Protein (4)

ENSG00000140368ENSG00000147010ENSG00000169217ENSG00000198087

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available