Protein detail
CD2
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Entry name CD2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Protein Class (4)
CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
210..235; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
SRBC
Gene Description
CD2 molecule
Chromosome
1
Position
116754430-116769229
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificskin 1Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificT-reg
Function & Pathway7
Protein Function (3)
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component (9)
Molecular Function (5)
Biological Process (3)
KEGG (3)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence181
Ligand-Receptor Signaling (50)
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
Protein Complex Composition (130)
130 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 23161513 |
Sequence, Structure & Domains10
Sequences
Length
351
Mass
39,448
Sequence
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
3D Structural Models
Turn
88..90; 139..142
Helix
62..64; 73..75; 99..101
Beta Strand
31..36; 41..43; 52..61; 67..71; 77..80; 84..86; 92..94; 103..111; 116..127; 134..138; 143..147; 155..162; 164..170; 172..175; 180..189; 194..203
3D Structure
NMR spectroscopy (3); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
243..262; Basic and acidic residues; 269..280; Polar residues; 326..338; Pro residues
Domain (FT)
25..128; Ig-like V-type; 129..209; Ig-like C2-type
Region
61..75; CD58 binding region 1; 106..120; CD58 binding region 2; 237..351; Disordered
Clinical Relevance9
Disease Involvement
FDA approved drug targets
Biomarker
Phase 2; Discontinued in Phase 2
Drug Targets
FDA approved drug targets
Drugs (9)
Interaction Protein (4)
ENSG00000140368ENSG00000147010ENSG00000169217ENSG00000198087
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |